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pro vyhledávání: '"Ben G. Zimmerman"'
Autor:
Ben G. Zimmerman
Publikováno v:
Clinical and Experimental Hypertension. 24:325-332
This study examined the proposition that kinins are involved in the renal hemodynamic effect of an ACE inhibitor in Goldblatt (GB) hypertension. The effects of the ACE inhibitor enalaprilat were compared in two groups of anesthetized two-kidney one-c
Autor:
Ben G. Zimmerman, Earl W Dunham
Publikováno v:
Annual Review of Pharmacology and Toxicology. 37:53-69
▪ Abstract In this review, we present background material that provides partial support for a tissue renin-angiotensin system (RAS). Evidence for the existence of this system relied in part the use of drugs, which has entailed using low doses or co
Autor:
Ben G. Zimmerman, Ke Chen
Publikováno v:
European Journal of Pharmacology. 284:281-288
Renal adrenergic interactions of intravenously and intrarenal arterially administered angiotensin II were studied in the anesthetized rabbit. Systemic arterial blood pressure and left renal blood flow were monitored. Bolus doses of angiotensin II, 50
Autor:
Tongchuan Li, Ben G. Zimmerman
Publikováno v:
Hypertension. 17:1010-1017
Evidence was sought for beta-adrenergic-induced increase in femoral vascular angiotensin production in sham-operated and nephrectomized rabbits. Systemic blood pressure and right femoral blood flow were monitored in anesthetized rabbits. Arterial and
Autor:
Ben G. Zimmerman, A F Hajj-ali
Publikováno v:
Hypertension. 17:504-509
This study was conducted to examine the role of bradykinin in the persistence of the renal vasodilator effect of captopril during angiotensin II receptor blockade. Blood pressure and renal blood flow were monitored in eight groups of pentobarbital-an
Publikováno v:
Circulation Research. 66:234-240
We examined the relative contribution of renin-angiotensin system blockade and bradykinin potentiation to the renal hemodynamic effect of the angiotensin converting enzyme inhibitor enalaprilat in sodium-deprived dogs. Six conscious dogs instrumented
Autor:
Ben G. Zimmerman
Publikováno v:
Clinical and experimental pharmacologyphysiology. 27(5-6)
SUMMARY 1. Renin inhibitors may be more advantageous than either angiotensin-converting enzyme (ACE) inhibitors or angiotensin (Ang) antagonists in blocking the renin–angiotensin system (RAS) because they do not allow accumulation of either AngI or
Autor:
Ben G. Zimmerman, Pauline C. Birt
Publikováno v:
American journal of hypertension. 10(3)
A microdissected rabbit intrarenal arterial network (IAN) perfused at constant flow with Krebs-bicarbonate solution was employed to determine whether this network, which has a high renin content, releases angiotensin II (AII) either spontaneously or
Kinin-mediated antihypertensive effect of captopril in deoxycorticosterone acetate-salt hypertension
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 27(1)
Abstract On the basis of evidence suggesting the activation of the kallikrein-kinin system in steroid-induced hypertension, we considered the possibility that the angiotensin-converting enzyme inhibitor captopril would lower the arterial blood pressu
Autor:
Pauline C. Birt, Ben G. Zimmerman
Publikováno v:
American journal of hypertension. 8(4 Pt 1)
The renin content, expressed as nanograms of angiotensin I/hour/milligram, of a rabbit intrarenal arterial network (IAN) was compared to that of renal cortical samples from the same animal. Tissues from six rabbits were studied. Cortical tissue (RC)