Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ben G N, Chappell"'
Autor:
Krishna Sharma, Hannah F. Sore, Warren R. J. D. Galloway, Laura S. Itzhaki, Yu Heng Lau, Ben G. N. Chappell, Matthew N. Grayson, David R. Spring, Wenshu Xu, Elaine Fowler, Alexander V. Strizhak
Publikováno v:
ACS Omega, Vol 5, Iss 2, Pp 1157-1169 (2020)
ACS Omega
Sharma, K, Strizhak, A V, Fowler, E, Xu, W, Chappell, B, Sore, H F, Galloway, W R J D, Grayson, M N, Lau, Y H, Itzhaki, L S & Spring, D R 2020, ' Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction ', ACS OMEGA, vol. 5, no. 2, pp. 1157-1169 . https://doi.org/10.1021/acsomega.9b03459
ACS Omega
Sharma, K, Strizhak, A V, Fowler, E, Xu, W, Chappell, B, Sore, H F, Galloway, W R J D, Grayson, M N, Lau, Y H, Itzhaki, L S & Spring, D R 2020, ' Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction ', ACS OMEGA, vol. 5, no. 2, pp. 1157-1169 . https://doi.org/10.1021/acsomega.9b03459
The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein–protein interactions. The substituted variants of the Sondheimer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85596b0bc40074ebbf5e51f681516480
https://eprints.whiterose.ac.uk/158648/1/acsomega.9b03459.pdf
https://eprints.whiterose.ac.uk/158648/1/acsomega.9b03459.pdf
Publikováno v:
Angewandte Chemie. 130:3232-3236
A palladium(II)-catalyzed γ-C-H amination of cyclic alkyl amines to deliver highly substituted azetidines is reported. The use of a benziodoxole tosylate oxidant in combination with AgOAc was found to be crucial for controlling a selective reductive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d111b4f42844fde8c31a67972839c95
https://doi.org/10.1002/ange.201800519
https://doi.org/10.1002/ange.201800519
Publikováno v:
Angewandte Chemie (International ed. in English). 57(12)
A palladium(II)-catalyzed γ-C-H amination of cyclic alkyl amines to deliver highly substituted azetidines is reported. The use of a benziodoxole tosylate oxidant in combination with AgOAc was found to be crucial for controlling a selective reductive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc36b6fca645f8885d9b43cbdef772c9
https://pubmed.ncbi.nlm.nih.gov/29380496
https://pubmed.ncbi.nlm.nih.gov/29380496
Autor:
Ben G. N. Chappell, Adam P. Smalley, Jonas Calleja, Matthew J. Gaunt, Darren Willcox, Kirsten F. Hogg
Publikováno v:
Willcox, D, Chappell, B G N, Hogg, K F, Calleja, J, Smalley, A P & Gaunt, M J 2016, ' A general catalytic β-C-H carbonylation of aliphatic amines to β-lactams ', Science, vol. 354, no. 6314, pp. 851-857 . https://doi.org/10.1126/science.aaf9621
CO takes the lead to make β-lactam rings Strained β-lactam rings are a key feature of penicillin and some other drugs. Willcox et al. designed a versatile route to these four-membered ring motifs through the palladiumcatalyzed coupling of carbon mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9996a0b05a10a3e3f3966519e43b78