Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ben E. Evans"'
Autor:
Heidi T. Orme, Jixin Wang, Joseph J. Salata, Ben E. Evans, Nancy K. Jurkiewicz, Michael C. Sanguinetti
Publikováno v:
Molecular Pharmacology. 54:220-230
The slowly activating delayed rectifier K+ current, IKs, is an important modulator of cardiac action potential repolarization. Here, we describe a novel benzodiazepine, [L-364,373 [(3-R)-1, 3-dihydro-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d0ecd8bbc42ac0ff4e38eea044c35a
https://doi.org/10.1124/mol.54.1.220
https://doi.org/10.1124/mol.54.1.220
Autor:
Kenneth E. Rittle, Raymond S.L. Chang, Daniel F. Veber, Willie L. Whitter, Mark G. Bock, Roger M. Freidinger, Paul S. Anderson, Ben E. Evans, Victor J. Lotti, Robert M. DiPardo
Publikováno v:
Journal of Controlled Release. 21:73-80
Cholecystokinin (CCK) is a polypeptide hormone which occurs in numerous molecular forms at various sites throughout the peripheral and central nervous systems. The wide range of physiological responses which have been attributed to CCK has stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::712adf34d6477bb58086f924e7c86a2e
https://doi.org/10.1016/0168-3659(92)90009-g
https://doi.org/10.1016/0168-3659(92)90009-g
Autor:
Kenneth E. Rittle, Daniel F. Veber, Roger M. Freidinger, Ben E. Evans, Raymond S. L. Chang, Willie L. Whitter, Victor J. Lotti, Mark G. Bock, Robert M. DiPardo, Tsing-Bau Chen
Publikováno v:
Journal of Medicinal Chemistry. 33:450-455
Tifluadom, a kappa-opioid agonist and cholecystokinin-A (CCK-A) receptor antagonist, was utilized as a model to prepare a series of 2-(aminomethyl)- and 3-(aminomethyl)-1,4-benzodiazepines. These compounds were tested in vitro as inhibitors of the bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c979655d204069844fb5b5aa665cabed
https://doi.org/10.1021/jm00163a069
https://doi.org/10.1021/jm00163a069
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461372103
There is currently a need for new therapeutic agents for treating preterm labor which could offer improved safety and efficacy beyond what has been achieved with the widely employed beta-mimetics. In this regard, the longstanding hypothesis of oxytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63e38f7cd0ad48cc7503813d25af160
https://doi.org/10.1007/978-1-4615-4871-3_61
https://doi.org/10.1007/978-1-4615-4871-3_61
Autor:
James B. Hoffman, Jill M. Erb, Kevin F. Gilbert, Daniel F. Veber, Roger M. Freidinger, Mark G. Bock, Robert M. DiPardo, Ben E. Evans, James L. Leighton, George F. Lundell, Douglas J. Pettibone, Bradley V. Clineschmidt, Willie L. Whitter, Roger D. Tung, Peter D. Williams, N. P. Gould, Debra S. Perlow
Publikováno v:
Peptides ISBN: 9789401090681
Peptides 1992
Peptides 1992 ISBN: 9789401046466
Peptides 1992
Peptides 1992 ISBN: 9789401046466
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571f6301248c7a3a088649e1aeae6c39
https://doi.org/10.1007/978-94-010-9066-7_17
https://doi.org/10.1007/978-94-010-9066-7_17
Autor:
Ben E. Evans, James L. Leighton, Kenneth E. Rittle, Kevin F. Gilbert, George F. Lundell, Norman P. Gould, Doug W. Hobbs, Robert M. DiPardo, Daniel F. Veber, Douglas J. Pettibone, Bradley V. Clineschmidt, Paul S. Anderson, Roger M. Freidinger
Publikováno v:
Journal of medicinal chemistry. 35(21)
The first nonpeptide antagonists of the neurohypophyseal hormone, oxytocin (OT) are described. Derivatives of the spiroindenepiperidine ring system, these compounds include L-366,509, an orally bioavailable OT antagonist with good in vivo duration. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c28cc7fbfb99640edb570aaa94fc64e
https://pubmed.ncbi.nlm.nih.gov/1331449
https://pubmed.ncbi.nlm.nih.gov/1331449
Autor:
Ben E. Evans, Paul S. Anderson, Marcia E. Christy, C. Dylion Colton, David C. Remy, Kenneth E. Rittle, Edward L. Engelhardt
Publikováno v:
The Journal of Organic Chemistry. 44:3127-3135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec32cd685212a9cb287258dbf2bfd8a3
https://doi.org/10.1021/jo01332a008
https://doi.org/10.1021/jo01332a008
Autor:
Victor J. Lotti, Kenneth E. Rittle, Robert M. DiPardo, Raymond S. L. Chang, Ben E. Evans, Mark G. Bock, Roger M. Freidinger
Publikováno v:
Journal of Medicinal Chemistry. 31:264-268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acd52c9ffaf577752c78b86864f5ca5
https://doi.org/10.1021/jm00396a042
https://doi.org/10.1021/jm00396a042
Autor:
Daniel F. Veber, Ben E. Evans, Carl F. Homnick, J. Hirshfield, Kenneth E. Rittle, James P. Springer
Publikováno v:
The Journal of Organic Chemistry. 50:4615-4625
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24639dc1b0afe1a20a41ceec1c41838f
https://doi.org/10.1021/jo00223a037
https://doi.org/10.1021/jo00223a037
Autor:
James P. Springer, Tsing-Bau Chen, Robert M. DiPardo, Roger M. Freidinger, Paul J. Kling, Paul S. Anderson, D. J. Cerino, K. A. Kunkel, Daniel F. Veber, J. Hirshfield, W. L. Whitter, Kenneth E. Rittle, Ben E. Evans, Victor J. Lotti, George F. Lundell, Mark G. Bock, Raymond S.L. Chang
Publikováno v:
Journal of Medicinal Chemistry. 31:2235-2246
3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described. Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2a10119f966b8cde83db84bb2d17e6
https://doi.org/10.1021/jm00120a002
https://doi.org/10.1021/jm00120a002