Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Ben E, Black"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Ultrastructure of human brain tissue has traditionally been examined using electron microscopy (EM) following fixation, staining, and sectioning, which limit resolution and introduce artifacts. Alternatively, cryo-electron tomography (cryo-E
Externí odkaz:
https://doaj.org/article/20e181ba98f141b9b9c17f2c03db17c6
Publikováno v:
eLife, Vol 13 (2024)
The physical basis of phase separation is thought to consist of the same types of bonds that specify conventional macromolecular interactions yet is unsatisfyingly often referred to as ‘fuzzy’. Gaining clarity on the biogenesis of membraneless ce
Externí odkaz:
https://doaj.org/article/bb7584e87cb0404fabab508905f3d31e
Autor:
Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine Dawicki-McKenna, Stine Malene Hansen Wøien, Manuel Carrer, Ben E Black, Michele Cascella, Nikolina Sekulic
Publikováno v:
eLife, Vol 12 (2023)
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is
Externí odkaz:
https://doaj.org/article/3f446e9c18754636af7992931cf4fafc
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
HPF1 controls the ADP-ribosylation activity of PARP1/2 in response to DNA breaks. Here, the authors show that HPF1 regulates the balance between ADP-ribose initiation and elongation through a dynamic interaction that accelerates the initiation rate o
Externí odkaz:
https://doaj.org/article/6078d4725d6843d48dcd1bc9e7b93b53
Autor:
Catalina Salinas-Luypaert, Praveen Kumar Allu, Glennis A. Logsdon, Jennine M. Dawicki-McKenna, Craig W. Gambogi, Daniele Fachinetti, Ben E. Black
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109924- (2021)
Summary: Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is def
Externí odkaz:
https://doaj.org/article/c312cc62e4fe4719a23103d6d0993732
The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle
Publikováno v:
Open Biology, Vol 10, Iss 6 (2020)
Eukaryotic chromosome segregation relies upon specific connections from DNA to the microtubule-based spindle that forms at cell division. The chromosomal locus that directs this process is the centromere, where a structure called the kinetochore form
Externí odkaz:
https://doaj.org/article/0b60aab021644cdf95496a19953e02d5
Autor:
Viviana Barra, Glennis A. Logsdon, Andrea Scelfo, Sebastian Hoffmann, Solène Hervé, Aaron Aslanian, Yael Nechemia-Arbely, Don W. Cleveland, Ben E. Black, Daniele Fachinetti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Phosphorylation of CENP-A on serine 7 has been proposed to control centromere assembly and function. Here, the authors use gene targeting at both endogenous CENP-A alleles and gene replacement in human cells to demonstrate that CENP-A that cannot be
Externí odkaz:
https://doaj.org/article/423a646c0dbd4210bde7daad24002f8e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Poly(ADP-ribose) polymerases (PARPs) catalyse ADP-ribose posttranslational modifications using NAD+ as a substrate. Here, the authors present the crystal structure of PARP-1 bound to the non-hydrolyzable NAD+ analog BAD and provide insights into the
Externí odkaz:
https://doaj.org/article/86fcef598c794822b2da2e8ca622e51d
Autor:
Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman, Ben E. Black
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Centromere maintenance depends on the persistence of the histone variant CENP-A at the centromeres. Here, the authors characterize the core centromeric nucleosome complex wherein CENP-C confers a stable CENP-A nucleosome conformation and CENP-N faste
Externí odkaz:
https://doaj.org/article/007ef2a91d124eb6baa7acd0387157c4
Publikováno v:
bioRxiv
The physical basis of phase separation is thought to consist of the same types of bonds that specify conventional macromolecular interactions yet is unsatisfyingly often referred to as ‘fuzzy’. Gaining clarity on the biogenesis of membraneless ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b7a7b38837d4acf648c620492372a6
https://europepmc.org/articles/PMC10245869/
https://europepmc.org/articles/PMC10245869/
