Výsledky vyhledávání - "Ben D. McNally"

Akademický článek

N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness

Autor: Allison M. Meadows, Kim Han, Komudi Singh, Antonio Murgia, Ben D. McNally, James A. West, Rebecca D. Huffstutler, Tiffany M. Powell-Wiley, Yvonne Baumer, Julian L. Griffin, Michael N. Sack

Publikováno v: iScience, Vol 26, Iss 5, Pp 106578- (2023)

Summary: Caloric deprivation interventions such as intermittent fasting and caloric restriction ameliorate metabolic and inflammatory disease. As a human model of caloric deprivation, a 24-h fast blunts innate and adaptive immune cell responsiveness

Externí odkaz: https://doaj.org/article/72dbf0ea57894d6e93e19b9ad9554f69

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Akademický článek

Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle

Autor: Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin, Lee D. Roberts

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activatio

Externí odkaz: https://doaj.org/article/e431ba3360bc41d78c30c04a825835be

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Akademický článek

Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

Autor: Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)

Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i

Externí odkaz: https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf

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Akademický článek

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have ant

Externí odkaz: https://doaj.org/article/d473c1c97b044c2fb72f34ce9316e47f

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Akademický článek

Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness

Autor: Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin

Publikováno v: Redox Biology, Vol 41, Iss , Pp 101907- (2021)

Background: Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiti

Externí odkaz: https://doaj.org/article/9c66267adf404de2a8e691584df51551

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Akademický článek

Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice

Autor: Alice P. Sowton, Nisha Padmanabhan, Simon J. Tunster, Ben D. McNally, Antonio Murgia, Aisha Yusuf, Julian L. Griffin, Andrew J. Murray, Erica D. Watson

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 23, Iss , Pp - (2020)

Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link,

Externí odkaz: https://doaj.org/article/b828d8c6f0654a398e8fa0e34097c012

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Akademický článek

Decrease in Myelin-Associated Lipids Precedes Neuronal Loss and Glial Activation in the CNS of the Sandhoff Mouse as Determined by Metabolomics

Autor: Emmanuelle Lecommandeur, Maria Begoña Cachón-González, Susannah Boddie, Ben D. McNally, Andrew W. Nicholls, Timothy M. Cox, Julian L. Griffin

Publikováno v: Metabolites, Vol 11, Iss 1, p 18 (2020)

Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the β subunit of β-hexosaminidase, leading to deficiency in the enzymes β-hexosaminidase (HEX) A and B. SD is characterised by an accumulation of gangliosides

Externí odkaz: https://doaj.org/article/2cfc0a9f51594020903d5a1919d93254

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Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness

Autor: James A. West, Michael P.W. Grocott, Bernadette O. Fernandez, Martin Feelisch, Julian L. Griffin, Daniel Martin, Magdalena Minnion, Adam Tod, Helen McKenna, Andrew J. Murray, Michael G. Mythen, Katie A. O'Brien, Ben D. McNally

Publikováno v: Redox Biology, Vol 41, Iss, Pp 101907-(2021)
Redox Biology

Background Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4fd19659c1696bd062cf9e51b3a5bc
http://www.sciencedirect.com/science/article/pii/S2213231721000550

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Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle

Autor: Ben D, McNally, Dean F, Ashley, Lea, Hänschke, Hélène N, Daou, Nicole T, Watt, Steven A, Murfitt, Amanda D V, MacCannell, Anna, Whitehead, T Scott, Bowen, Francis W B, Sanders, Michele, Vacca, Klaus K, Witte, Graeme R, Davies, Reinhard, Bauer, Julian L, Griffin, Lee D, Roberts

Publikováno v: Nature communications. 13(1)

The endoplasmic reticulum (ER) regulates cellular protein and lipid biosynthesis. ER dysfunction leads to protein misfolding and the unfolded protein response (UPR), which limits protein synthesis to prevent cytotoxicity. Chronic ER stress in skeleta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::136343b99869ea2fdc2bd8946d79edab
https://pubmed.ncbi.nlm.nih.gov/35365625

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Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35c35aa1f5dc2a16de5ff5b842bce2a
http://europepmc.org/articles/PMC7998027

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