Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ben Cons"'
Autor:
Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
Publikováno v:
Journal of Medicinal Chemistry. 64:4071-4088
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2c962765a3d64c4d7d02d50fd31b0d
https://doi.org/10.1021/acs.jmedchem.0c02188
https://doi.org/10.1021/acs.jmedchem.0c02188
Autor:
S Wedge, Roger J. Griffin, Maria Ahn, Karen Haggerty, Juan Castro, Ian R. Hardcastle, Celine Cano, Christopher N. Johnson, Bernard T. Golding, Herbie Newell, Steven Howard, Luke Bevan, Timothy J. Blackburn, Pamela A. Williams, Martin E.M. Noble, Yan Zhao, Judith Reeks, Ruth H. Bawn, Neil Thompson, Emiliano Tamanini, Ben Cons, Huw Thomas, Lynsey Fazal, Hugh Walton, Elaine Willmore, Sarah J. Cully, Gianni Chessari, Keisha Hearn, Ildiko Maria Buck
Publikováno v:
Cancer Research. 78:1652-1652
In response to cellular stress, the p53 tumor suppressor is activated to modulate cell cycle progression, DNA repair, and cell death. The activity of p53 is tightly regulated by MDM2, an E3 ubiquitin ligase that targets p53 for proteasomal degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f11828bba8837e5bc77a00d94f5218f
https://doi.org/10.1158/1538-7445.am2018-1652
https://doi.org/10.1158/1538-7445.am2018-1652