Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ben C. B. Ko"'
Autor:
Rui Zhang, Chris Y. Cheung, Sang-Uk Seo, Hang Liu, Lakhansing Pardeshi, Koon Ho Wong, Larry M. C. Chow, Mary P. Chau, Yixiang Wang, Ah Ra Lee, Woon Yong Kwon, Sheng Chen, Bill Kwan-wai Chan, Kenneth Wong, Richard K. W. Choy, Ben C. B. Ko
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages play an important role in the host defense mechanism. In response to infection, macrophages activate a genetic program of pro-inflammatory response to kill any invading pathogen, and initiate an adaptive immune response. We have identifie
Externí odkaz:
https://doaj.org/article/73c5cecb1e1348179fadfe22111b3410
Autor:
Vincent Kam Wai Wong, Wu Zeng, Juan Chen, Xiao Jun Yao, Elaine Lai Han Leung, Qian Qian Wang, Pauline Chiu, Ben C. B. Ko, Betty Yuen Kwan Law
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Emerging evidence suggests the therapeutic role of autophagic modulators in cancer therapy. This study aims to identify novel traditional Chinese medicinal herbs as potential anti-tumor agents through autophagic induction, which finally lead to autop
Externí odkaz:
https://doaj.org/article/2671d2b05b0b488eb94d6b2e2721b9cf
Publikováno v:
Biochemistry and biophysics reports. 33
Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer cases and ranks as the second leading cause of cancer related death. Multiple receptor tyrosine kinases such as EGFR, FGFR and c-MET have been shown to drive tumori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10e2b647877a5aceff2434ff26d06c3c
https://pubmed.ncbi.nlm.nih.gov/36578529
https://pubmed.ncbi.nlm.nih.gov/36578529
Autor:
Chris Y. Cheung, Ting-Ting Huang, Ning Chow, Shuqi Zhang, Yanxiang Zhao, Mary P. Chau, Wing Cheung Chan, Catherine C. L. Wong, Daniela Boassa, Sebastien Phan, Mark H. Ellisman, John R. Yates, SongXiao Xu, Zicheng Yu, Yajing Zhang, Rui Zhang, Ling Ling Ng, Ben C. B. Ko
Publikováno v:
Journal of Cell Science. 135
NFAT5 is the only known mammalian tonicity-responsive transcription factor with an essential role in cellular adaptation to hypertonic stress. It is also implicated in diverse physiological and pathological processes. NFAT5 activity is tightly regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f14a33c8839ebff8a9a11f2485edda3
https://doi.org/10.1242/jcs.259280
https://doi.org/10.1242/jcs.259280
Autor:
Carlos E. Irarrazabal, Yair Serman, Ben C. B. Ko, Flavio Carrión, Rodrigo A. Fuentealba, Consuelo Pasten, Jocelyn Rocco
Publikováno v:
American Journal of Physiology-Cell Physiology. 317:C31-C38
We previously described the protective role of the nuclear factor of activated T cells 5 (NFAT5) during hypoxia. Alternatively, inducible nitric oxide synthase (iNOS) is also induced by hypoxia. Some evidence indicates that NFAT5 is essential for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f057de5e8e78d79e45e1e661d4a094
https://doi.org/10.1152/ajpcell.00054.2019
https://doi.org/10.1152/ajpcell.00054.2019
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84931 (2014)
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase that is implicated in plethora of biological processes, including metabolism, aging, stress response, and tumorigenesis. Telomerase (TERT) is essential for telomere
Externí odkaz:
https://doaj.org/article/afcfa4bffecf432f8377ef0029fbf91b
Autor:
Edith H Y Tong, Jin-Jun Guo, Song-Xiao Xu, Keri Mak, Sookja K Chung, Stephen S M Chung, Ali-Long Huang, Ben C B Ko
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8435 (2009)
BACKGROUND:Osmotic Response Element-Binding Protein (OREBP), also known as TonEBP or NFAT5, is a unique transcription factor. It is hitherto the only known mammalian transcription factor that regulates hypertonic stress-induced gene transcription. In
Externí odkaz:
https://doaj.org/article/1ba10272071c4fa7a6136bcfb6866396