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Autor:
Jie Mu, David Levens, Zuqin Nie, Ballachanda N. Devaiah, Dinah S. Singer, Dan Cheng, Sheetal Uppal, Jocelyn D. Weissman, Laura Baranello, Ben Akman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Dysregulation of MYC protein levels is associated with most human cancers. MYC is regulated by both transcription and protein stability. BRD4, a driver of oncogenesis that activates Myc transcription, is being investigated as a therapeut