Characterization of variably protease-sensitive prionopathy by capillary electrophoresis

Autor: Jennifer Myskiw, Ben A. Bailey-Elkin, Kristen Avery, Marcelo A. Barria, Diane L. Ritchie, Mark L. Cohen, Brian S. Appleby, Stephanie A Booth

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Variably Protease Sensitive Prionopathy (VPSPr) is a rare human prion disease that, like Creutzfeldt-Jakob disease (CJD), results in the deposition of abnormally folded prion protein aggregates in the brain and is ultimately fatal. Neuropath

Externí odkaz: https://doaj.org/article/64256f7c1612469ea8d0f61d71c293de

Characterization of the sorbitol dehydrogenase SmoS from Sinorhizobium meliloti 1021

Autor: Brian L. Mark, MacLean G. Kohlmeier, Ben A. Bailey-Elkin, Ivan J. Oresnik

Publikováno v: Acta Crystallographica Section D Structural Biology. 77:380-390

Sinorhizobium meliloti 1021 is a Gram-negative alphaproteobacterium with a robust capacity for carbohydrate metabolism. The enzymes that facilitate these reactions assist in the survival of the bacterium across a range of environmental niches, and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a9925b725985857dd9ac2e699b09d0
https://doi.org/10.1107/s2059798321001017

Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein

Autor: Matthias Götte, Brian L. Mark, Ben A. Bailey-Elkin, Egor P. Tchesnokov

Publikováno v: Proceedings, Vol 50, Iss 41, p 41 (2020)
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008283 (2020)
PLoS Neglected Tropical Diseases

Background The Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFVas a priority pathogen with an urgent need for enhanced rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e9acae14da262406cf341f3a82fa0b
https://www.mdpi.com/2504-3900/50/1/41

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants

Autor: Baldeep Khare, Nigel J. McLeish, Marjolein Kikkert, Tim J. Dalebout, Sachdev S. Sidhu, Garrett G R J Johnson, Wenguang He, Robert C. M. Knaap, Puck B. van Kasteren, Brian L. Mark, Wei Zhang, Jun Gu, Ben A. Bailey-Elkin

Publikováno v: PLoS Pathogens
PLOS Pathogens
PLoS Pathogens, Vol 13, Iss 5, p e1006372 (2017)
PLoS Pathogens, 13(5)
Acta Pharmacologica Sinica, 38(7), 1082-1082

The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6f89f330debdc06a84dfdf42958995
https://hdl.handle.net/1887/114581

Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase

Autor: Brian L. Mark, John-Paul Bacik, David J. Vocadlo, Anuj K. Yadav, Ben A. Bailey-Elkin, Garrett E. Whitworth, Dylan R. Martin, Keith A. Stubbs

Publikováno v: Journal of Biological Chemistry. 286:12283-12291

Anhydro-N-acetylmuramic acid kinase (AnmK) catalyzes the ATP-dependent conversion of the Gram-negative peptidoglycan (PG) recycling intermediate 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) to N-acetylmuramic acid-6-phosphate (MurNAc-6-P). Here we pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d827e11ef582e2efacb2050ac51c16b
https://doi.org/10.1074/jbc.m110.198317