Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Ben A, Barres"'
Autor:
Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter, Steven A. Sloan
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background The important contribution of glia to mechanisms of injury and repair of the nervous system is increasingly recognized. In stark contrast to the central nervous system (CNS), the peripheral nervous system (PNS) has a remarkable ca
Externí odkaz:
https://doaj.org/article/f76f22d3e17d4948b45984c355586a61
Autor:
Kevin A. Guttenplan, Maya K. Weigel, Drew I. Adler, Julien Couthouis, Shane A. Liddelow, Aaron D. Gitler, Ben A. Barres
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Astrocyte activation may contribute to neurodegenerative disease. Here the authors show that the combined knockout of three factors known to promote astrogliosis, IL-1α, TNFα and C1qa, leads to improved survival in the SOD1 G93A mouse model of ALS.
Externí odkaz:
https://doaj.org/article/04bb3c77114848c1a13fa651c535c520
Autor:
Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. Mentis
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3087-3100.e7 (2019)
Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood. Similarly, the molecular mechanisms b
Externí odkaz:
https://doaj.org/article/b00b1ef1c3644734996365a67dfccaaa
Autor:
Spyros Darmanis, Steven A. Sloan, Derek Croote, Marco Mignardi, Sophia Chernikova, Peyman Samghababi, Ye Zhang, Norma Neff, Mark Kowarsky, Christine Caneda, Gordon Li, Steven D. Chang, Ian David Connolly, Yingmei Li, Ben A. Barres, Melanie Hayden Gephart, Stephen R. Quake
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1399-1410 (2017)
Summary: Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq) on 3,589 cells in a cohort of four patients. We obtai
Externí odkaz:
https://doaj.org/article/bf12d57bf0314dcea53a803c49777459
Autor:
Romain Madelaine, Steven A. Sloan, Nina Huber, James H. Notwell, Louis C. Leung, Gemini Skariah, Caroline Halluin, Sergiu P. Paşca, Gill Bejerano, Mark A. Krasnow, Ben A. Barres, Philippe Mourrain
Publikováno v:
Cell Reports, Vol 20, Iss 7, Pp 1533-1542 (2017)
In the developing brain, neurons expressing VEGF-A and blood vessels grow in close apposition, but many of the molecular pathways regulating neuronal VEGF-A and neurovascular system development remain to be deciphered. Here, we show that miR-9 links
Externí odkaz:
https://doaj.org/article/afa35b6d422241ad859ef95b839bfc3f
Autor:
Louis-Philippe Bernier, Christopher J. Bohlen, Elisa M. York, Hyun B. Choi, Alireza Kamyabi, Lasse Dissing-Olesen, Jasmin K. Hefendehl, Hannah Y. Collins, Beth Stevens, Ben A. Barres, Brian A. MacVicar
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2895-2908.e4 (2019)
Summary: Microglia, the brain’s immune cells, maintain homeostasis and sense pathological changes by continuously surveying the parenchyma with highly motile large processes. Here, we demonstrate that microglia also use thin actin-dependent filopod
Externí odkaz:
https://doaj.org/article/f4a5ba30a4b14557bf6be3381040748f
Autor:
Brian V. Lananna, Collin J. Nadarajah, Mariko Izumo, Michelle R. Cedeño, David D. Xiong, Julie Dimitry, Chak Foon Tso, Celia A. McKee, Percy Griffin, Patrick W. Sheehan, Jeffery A. Haspel, Ben A. Barres, Shane A. Liddelow, Joseph S. Takahashi, Ilia N. Karatsoreos, Erik S. Musiek
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 1-9.e5 (2018)
Summary: Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults and plays a critical role in brain he
Externí odkaz:
https://doaj.org/article/4038189a9a7b4a11ab4df6e5da08d184
Autor:
Prageeth R. Wijewardhane, Maya K. Weigel, Gaurav Chopra, Uriel Rufen-Blanchette, Priya Prakash, Jacob A. Blum, Shane A. Liddelow, Jonathan Fine, Aaron D. Gitler, Mikaela C. Neal, Kimberley D. Bruce, Philip Hasel, Kevin A. Guttenplan, Alexandra E. Münch, Ben A. Barres
Publikováno v:
Nature. 599:102-107
Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease1–6. Here we report an approach to isolate one component of the long-sought astrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d67a7fcbc3e7da504806c704c77cce
https://doi.org/10.1038/s41586-021-03960-y
https://doi.org/10.1038/s41586-021-03960-y
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 429-438 (2012)
Gabapentin (GBP) is an anticonvulsant that acts at the α2δ-1 submit of the L-type calcium channel. It is recently reported that GBP is a potent inhibitor of thrombospondin (TSP)-induced excitatory synapse formation in vitro and in vivo. Here we stu
Externí odkaz:
https://doaj.org/article/434af3e908444459b84e0711b700398d
Autor:
Xiaomin Dong, Kenian Chen, Raquel Cuevas-Diaz Duran, Yanan You, Steven A Sloan, Ye Zhang, Shan Zong, Qilin Cao, Ben A Barres, Jia Qian Wu
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005669 (2015)
Long non-coding RNAs (lncRNAs) (> 200 bp) play crucial roles in transcriptional regulation during numerous biological processes. However, it is challenging to comprehensively identify lncRNAs, because they are often expressed at low levels and with m
Externí odkaz:
https://doaj.org/article/1e59263f92d44ad99a2c50c6409b1c3c