Výsledky vyhledávání - "Ben, Van Camp"

Data from Synergistic Induction of Apoptosis in Multiple Myeloma Cells by Bortezomib and Hypoxia-Activated Prodrug TH-302, In Vivo and In Vitro

Autor: Karin Vanderkerken, Charles P. Hart, Damian Handisides, Ben Van Camp, Song Xu, Elke De Bryune, Hendrik De Raeve, Eline Menu, Dehui Xu, Els Van Valckenborgh, Jinsong Hu

Recently, we showed that hypoxia is a critical microenvironmental factor in multiple myeloma, and that the hypoxia-activated prodrug TH-302 selectively targets hypoxic multiple myeloma cells and improves multiple disease parameters in vivo. To explor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e37099d13a0466aafb31e874db9ce20
https://doi.org/10.1158/1535-7163.c.6536424

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Data from The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin

Autor: Karin Vanderkerken, Helena Jernberg-Wiklund, Ben Van Camp, Magnus Axelson, Olle Larsson, Peter Atadja, Anders Österborg, Elke De Bruyne, Els Van Valckenborgh, Eline Menu, Prasoon Agarwal, Charlotte Fristedt, Miguel Lemaire

Purpose: We have previously shown the use of the insulin-like growth factor type 1 receptor tyrosine kinase (IGF-1RTK) inhibitor picropodophyllin (PPP) as an attractive strategy to combat multiple myeloma (MM) in vitro and in vivo. After a combinator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c18412a7e70b299486f0d81b4b8c295
https://doi.org/10.1158/1078-0432.c.6519953

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Akademický článek

Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients.

Autor: Song Xu, Gaia Cecilia Santini, Kim De Veirman, Isabelle Vande Broek, Xavier Leleu, Ann De Becker, Ben Van Camp, Karin Vanderkerken, Ivan Van Riet

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79752 (2013)

Previous studies have demonstrated that mesenchymal stem cells from multiple myeloma (MM) patients (MM-hMSCs) display a distinctive gene expression profile, an enhanced production of cytokines and an impaired osteogenic differentiation ability compar

Externí odkaz: https://doaj.org/article/be27b4876df14282a1fa2b2463b531a8

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Akademický článek

Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma

Autor: Jo Caers, Dirk Hose, Ine Kuipers, Tomas Jan Bos, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Hartmut Goldschmidt, Ben Van Camp, Bernard Klein, Karin Vanderkerken

Publikováno v: Haematologica, Vol 95, Iss 1 (2010)

Thymosin β4 (Tβ4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murin

Externí odkaz: https://doaj.org/article/f25fb01ae4ac441aa010078706516df4

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Akademický článek

Histone deacetylase inhibitors in multiple myeloma

Autor: Sarah Deleu, Eline Menu, Els Van Valckenborgh, Ben Van Camp, Joanna Fraczek, Isabelle Vande Broek, Vera Rogiers, Karin Vanderkerken

Publikováno v: Hematology Reports, Vol 1, Iss 1, Pp e9-e9 (2009)

Novel drugs such as bortezomib and high dose chemotherapy combined with stem cell transplantation improved the outcome of multiple myeloma patients in the past decade. However, multiple myeloma often remains incurable due to the development of drug r

Externí odkaz: https://doaj.org/article/d9a455885af74fe4bf096390c62d65c6

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Thymosin 4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma

Autor: Elke De Bruyne, Ine Kuipers, Hartmut Goldschmidt, Tomas Bos, Karin Vanderkerken, Bernard Klein, Eline Menu, Els Van Valckenborgh, Ben Van Camp, Dirk Hose, Jo Caers

Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2010, 95 (1), pp.163-7. ⟨10.3324/haematol.2009.006411⟩

International audience; Thymosin beta4 (Tbeta4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311ff4d41b586ebbb00d861ab1415003
https://doi.org/10.3324/haematol.2009.006411

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