Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ben, Ouyang"'
Autor:
Zenhwa Ben Ouyang, Jennifer Louise Hodgson, Elliot Robson, Kevin Havas, Elizabeth Stone, Zvonimir Poljak, Theresa Marie Bernardo
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
In 2015, the American Association of Veterinary Medical Colleges (AAVMC) developed the Competency-Based Veterinary Education (CBVE) framework to prepare practice-ready veterinarians through competency-based education, which is an outcomes-based appro
Externí odkaz:
https://doaj.org/article/489b8fc7630245fab2b708fbdd51aa63
Autor:
Zachary Pengju Lin, Luan N. M. Nguyen, Ben Ouyang, Presley MacMillan, Jessica Ngai, Benjamin R. Kingston, Stefan M. Mladjenovic, Warren C. W. Chan
Publikováno v:
ACS Nano. 16:6080-6092
Nanoparticles need to navigate a complex microenvironment to target cells in solid tumors after extravasation. Diffusion is currently the accepted primary mechanism for nanoparticle distribution in tumors. However, the extracellular matrix can limit
Autor:
Jessica Ngai, Presley MacMillan, Benjamin R. Kingston, Zachary P. Lin, Ben Ouyang, Warren C.W. Chan
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 353
Nanoparticles can reduce cytotoxicity, increase circulation time and increase accumulation in tumours compared to free drug. However, the value of using nanoparticles for carrying small molecules to treat tumours at the cellular level has been poorly
Autor:
Shrey Sindhwani, Zachary P. Lin, Ben Ouyang, Jessica Ngai, Benjamin R. Kingston, Presley MacMillan, Abdullah Muhammad Syed, Warren C. W. Chan
Publikováno v:
ACS Nano. 15:14080-14094
The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we discovered a subset of tumor endothelial cells that facilitate nanoparticle transport into s
Publikováno v:
Current Computer-Aided Drug Design. 16:564-570
Background: Pyrazol-5-amine derivatives are an important class of heterocyclic compounds. However, there are less 4-alkyl substituted pyrazoles reported. Objective: Here reported are the design, synthesis and biological evaluation of 3-aryl-4- alkylp
Autor:
Ben Ouyang, Benjamin R. Kingston, Wilson Poon, Yi-Nan Zhang, Zachary P. Lin, Abdullah M. Syed, Julien Couture-Senécal, Warren C. W. Chan
Publikováno v:
Molecular pharmaceutics. 19(6)
The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the delivery of g
Autor:
Anthony J. Tavares, Yi-Nan Zhang, Gang Zheng, Warren C. W. Chan, Julien Couture-Senécal, Juan Chen, Zachary P. Lin, Yuwei Zhang, Wilson Poon, Benjamin R. Kingston, Presley MacMillan, Abdullah Muhammad Syed, Ben Ouyang, Michael S. Valic
Publikováno v:
Nature Materials. 19:1362-1371
Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of 0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only minor improvements. Here we discovered a dose threshold for improving
Publikováno v:
Iranian Journal of Pharmaceutical Research : IJPR
Rho-associated kinases (ROCK) are a class of serine/threonine kinases that play important roles in various biological processes. ROCK are becoming attractive targets for drug designing. A novel scaffold was designed according to molecular hybridizati
Autor:
Jennifer L. Hodgson, Theresa M. Bernardo, Zenhwa Ben Ouyang, Elliot Robson, Kevin Havas, Zvonimir Poljak, Elizabeth A. Stone
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Frontiers in Veterinary Science
Frontiers in Veterinary Science
In 2015, the American Association of Veterinary Medical Colleges (AAVMC) developed the Competency-Based Veterinary Education (CBVE) framework to prepare practice-ready veterinarians through competency-based education, which is an outcomes-based appro
Publikováno v:
Journal of Controlled Release. 304:102-110
Studies into the interactions of serum proteins with nanoparticles are typically performed using nanoparticles that are larger than the size of proteins. Due to this size discrepancy, adsorbed proteins are commonly depicted as a globular structure su