Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Ben, Murrell"'
Autor:
Marco Mandolesi, Hrishikesh Das, Liset de Vries, Yiqiu Yang, Changil Kim, Manojj Dhinakaran, Xaquin Castro Dopico, Julian Fischbach, Sungyong Kim, Mariia V. Guryleva, Monika Àdori, Mark Chernyshev, Aron Stålmarck, Leo Hanke, Gerald M. McInerney, Daniel J. Sheward, Martin Corcoran, B. Martin Hällberg, Ben Murrell, Gunilla B. Karlsson Hedestam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The continued evolution of SARS-CoV-2 underscores the need to understand qualitative aspects of the humoral immune response elicited by spike immunization. Here, we combine monoclonal antibody (mAb) isolation with deep B cell receptor (BCR)
Externí odkaz:
https://doaj.org/article/dd5bb1c8958649a5ad5a309a8a4fa7ee
Autor:
Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J. Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract The immune responses to Novavax’s licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-MTM adjuvanted vaccines predominant
Externí odkaz:
https://doaj.org/article/c088a289c59c484090d22680d31eac78
Autor:
Xaquin Castro Dopico, Mariia Guryleva, Marco Mandolesi, Martin Corcoran, Jonathan M Coquet, Ben Murrell, Gunilla B Karlsson Hedestam
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Objectives The caecum bridges the small and large intestine and plays a front‐line role in discriminating gastrointestinal antigens. Although dysregulated in acute and chronic conditions, the tissue is often overlooked immunologically. Met
Externí odkaz:
https://doaj.org/article/b3af460353a4443abeb7b533cc7ff58f
Autor:
Mark Chernyshev, Mrunal Sakharkar, Ruth I. Connor, Haley L. Dugan, Daniel J. Sheward, C. G. Rappazzo, Aron Stålmarck, Mattias N. E. Forsell, Peter F. Wright, Martin Corcoran, Ben Murrell, Laura M. Walker, Gunilla B. Karlsson Hedestam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Vaccination of SARS-CoV-2 convalescent individuals generates broad and potent antibody responses. Here, we isolate 459 spike-specific monoclonal antibodies (mAbs) from two individuals who were infected with the index variant of SARS-CoV-2 an
Externí odkaz:
https://doaj.org/article/9dd4d91fffe54e7ea8233be911d4cbb4
Autor:
Caroline Dufour, Corentin Richard, Marion Pardons, Marta Massanella, Antoine Ackaoui, Ben Murrell, Bertrand Routy, Réjean Thomas, Jean-Pierre Routy, Rémi Fromentin, Nicolas Chomont
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Some HIV-infected cells persist during antiretroviral therapies (ART) but their phenotype is less clear. Dufour et al. show that HIV-infected cells that persist in people receiving ART are phenotypically diverse and that CD4+ T cells expressing the i
Externí odkaz:
https://doaj.org/article/d6e5f3fc8d40447e8c9072fd1b7df7f4
Autor:
Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna, Leo Hanke, Monika Àdori, Daniel J. Sheward, Sina Teifel, Shreekara Gopalakrishna, Qiuya Shao, Yong Liu, Keying Zhu, Robert A. Harris, Gerald McInerney, Ben Murrell, Mike Aoun, Liselotte Bäckdahl, Rikard Holmdahl, Marcin Pekalski, Anna Wedell, Martin Engvall, Anna Wredenberg, Gunilla B. Karlsson Hedestam, Xaquin Castro Dopico, Joanna Rorbach
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from abnormal im
Externí odkaz:
https://doaj.org/article/06ca1318ae034d2c89248663f7d9045f
Autor:
Collin Joyce, Sasha Murrell, Ben Murrell, Oluwarotimi Omorodion, Lorena S Ver, Nancy Carrico, Raiza Bastidas, Rebecca Nedellec, Michael Bick, Jordan Woehl, Fangzhu Zhao, Alison Burns, Shawn Barman, Michael Appel, Alejandra Ramos, Lalinda Wickramasinghe, Kemal Eren, Thomas Vollbrecht, Davey M Smith, Sergei L Kosakovsky Pond, Ryan McBride, Charli Worth, Facundo Batista, Devin Sok, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Pascal Poignard, Bryan Briney, Ian A Wilson, Elise Landais, Dennis R Burton
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011416 (2023)
Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve precursors are hindered by unusual features that characterize these Abs, including insertions and deletions (indels). Longitudinal studies of natural HIV inf
Externí odkaz:
https://doaj.org/article/f3290d1bda334e7a969850f0b8f21e00
Autor:
Anouschka Akerman, Vanessa Milogiannakis, Tyra Jean, Camille Esneau, Mariana Ruiz Silva, Timothy Ison, Christina Fichter, Joseph A. Lopez, Deborah Chandra, Zin Naing, Joanna Caguicla, Daiyang Li, Gregory Walker, Supavadee Amatayakul-Chantler, Nathan Roth, Sandro Manni, Thomas Hauser, Thomas Barnes, Anna Condylios, Malinna Yeang, Maureen Wong, Charles S.P. Foster, Kenta Sato, Sharon Lee, Yang Song, Lijun Mao, Allison Sigmund, Amy Phu, Ann Marie Vande More, Stephanie Hunt, Mark Douglas, Ian Caterson, Warwick Britton, Kerrie Sandgren, Rowena Bull, Andrew Lloyd, Jamie Triccas, Stuart Tangye, Nathan W. Bartlett, David Darley, Gail Matthews, Damien J. Stark, Kathy Petoumenos, William D. Rawlinson, Ben Murrell, Fabienne Brilot, Anthony L. Cunningham, Anthony D. Kelleher, Anupriya Aggarwal, Stuart G. Turville
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104545- (2023)
Summary: Background: The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave
Externí odkaz:
https://doaj.org/article/c20ddc7898f64d7197436749654ce9c9
Autor:
Pradeepa Pushparaj, Andrea Nicoletto, Xaquin Castro Dopico, Daniel J. Sheward, Sungyong Kim, Simon Ekström, Ben Murrell, Martin Corcoran, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spik
Externí odkaz:
https://doaj.org/article/e2a07f927a7947e584bcb85beca8d4d7
Autor:
Leo Hanke, Hrishikesh Das, Daniel J. Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L. Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K. Pedersen, Jonathan M. Coquet, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here, the authors isolate and characterize a bispecific monomeric nanobody that induces dimerization of SARS-CoV-2 spike trimers, neutralizes variants of concerns as well as SARS-CoV, and inhibits SARS-CoV-2 infection in mice.
Externí odkaz:
https://doaj.org/article/f14234a7e3914ec1bbba1c457db3bda6