Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Ben, Moree"'
1
Akademický článek
ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
Autor: Bin Ma, Doug Marcotte, Murugan Paramasivam, Klaus Michelsen, Ti Wang, Andrea Bertolotti-Ciarlet, John Howard Jones, Ben Moree, Margaret Butko, Joshua Salafsky, Xin Sun, Timothy McKee, Laura F Silvian
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165983 (2016)
MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for
Externí odkaz: https://doaj.org/article/67003a59dd434add954b7cdabddde7a6
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2
Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors
Autor: Sandra Eltschkner, Weixuan Yu, Jonathan Merino, Caroline Kisker, James J. Truglio, Eleanor K. H. Allen, Ben Moree, Neil Thivalapill, Shabnam Davoodi, Lauren A. Spagnuolo, Peter J. Tonge, Joshua Salafsky, Richard A. Slayden, Fereidoon Daryaee, Annica Pschibul, Susan E. Knudson
Publikováno v: Journal of the American Chemical Society. 139:3417-3429
A critical goal of lead compound selection and optimization is to maximize target engagement whilst minimizing off-target binding. Since target engagement is a function of both the thermodynamics and kinetics of drug-target interactions, it follows t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeb1c371c30e265b18e7730ec471249
https://doi.org/10.1021/jacs.6b11148
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3
Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder
Autor: Gabriel Mercado, Paul T. Wilder, Joshua Salafsky, Sina Khorsand, Alexander D. MacKerell, Kristen M. Varney, Que N. Van, Andrew G. Stephen, Frank McCormick, Ben Moree, Wenbo Yu, David J. Weber, Patrick Alexander, Elizabeth Donohue
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 35
Second harmonic generation (SHG) is an emergent biophysical method that sensitively measures real-time conformational change of biomolecules in the presence of biological ligands and small molecules. This study describes the successful implementation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb5bcb2eb61d1a8a2bfc4a0def4d862
https://pubmed.ncbi.nlm.nih.gov/31399543
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4
Angular Mapping of Protein Structure Using Nonlinear Optical Measurements
Autor: Ben Moree, Bason E. Clancy, Joshua Salafsky
Publikováno v: Biophysical journal, vol 117, iss 3
Biophysical Journal
Proteins are inherently dynamic, flexible molecules that execute precise conformational changes to perform their functions, but existing techniques to directly measure relevant structural changes in solution at room temperature remain limited. Here,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa76dc4b98e86fe3bab731865faa0d1
https://escholarship.org/uc/item/5n94g22t
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5
Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening
Autor: Juan J. Carrillo, Ben Moree, John Strelow, Mary Geck Do, Joshua Salafsky, Tracy A. Young, Bason Clancy, Tarun Gheyi, Margaret T. Butko
Second-harmonic generation (SHG) has recently emerged as a biophysical tool for conformational sensing of a target biomolecule upon binding to ligands such as small molecules, fragments, proteins, peptides, and oligonucleotides. To date, SHG has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd85075312fdb7e806432d39d62ac79a
https://doi.org/10.1016/bs.mie.2018.09.017
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6
Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells
Autor: Guowei Yin, Karin Giller, Markus Zweckstetter, Tiago F. Outeiro, Timo Strohäker, Francesca Munari, Joshua Salafsky, Ben Moree, Diana F. Lázaro, Stefan Becker
Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry
The journal of biological chemistry 290(46), 27582-27593 (2015). doi:10.1074/jbc.M114.636027
Background: α-Synuclein aggregation is associated with Parkinson disease. Results: Small molecules were identified by second-harmonic generation (SHG) that change α-synuclein conformation in vitro and reduce the aggregation of protein in cells. Con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94d4e41f529440ed17d7b805a1a18ab
https://doi.org/10.1074/jbc.m114.636027
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8
Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation at a Supported Lipid Bilayer Interface
Autor: Margaret T. Butko, Ben Moree, Richard B. Mortensen, Joshua Salafsky
Publikováno v: Analytical chemistry. 88(21)
There is a high demand for characterizing oligonucleotide structural changes associated with binding interactions as well as identifying novel binders that modulate their structure and function. In this study, second-harmonic generation (SHG) was use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f112677942f2aac68207a0c61271362
https://pubmed.ncbi.nlm.nih.gov/27696827
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9
ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis
Autor: Joshua Salafsky, Ti Wang, Xin E. Sun, Bin Ma, Klaus Michelsen, Laura Silvian, Timothy D. McKee, Murugan Paramasivam, John Howard Jones, Margaret T. Butko, Andrea Bertolotti-Ciarlet, Douglas Marcotte, Ben Moree
Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0165983 (2016)
MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37384f1d47e19dfb65e28d90cd0edd90
http://europepmc.org/articles/PMC5104457
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10
CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly
Autor: Colin J. Fuller, Aaron F. Straight, Corey B. Meyer, Ben Moree
Publikováno v: The Journal of Cell Biology
CENP-C provides a link between existing CENP-A chromatin and the proteins required for new CENP-A nucleosome assembly.
Eukaryotic chromosomes segregate by attaching to microtubules of the mitotic spindle through a chromosomal microtubule binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0431175e634be04d1140ab28a24c052a
https://doi.org/10.1083/jcb.201106079
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