Zobrazeno 1 - 10
of 697
pro vyhledávání: '"Ben, Berkhout"'
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background The capsid p24 (CA-p24) antigen is a component of the viral capsid of human immunodeficiency virus (HIV) that has been commonly used for clinical diagnosis and monitoring of HIV infections in Enzyme-linked Immunosorbent Assays (EL
Externí odkaz:
https://doaj.org/article/90061cd9d63448a082929d924d46fefe
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115046- (2023)
Background: The novel endonuclease Cas12b was engineered for targeted genome editing in mammalian cells and is a promising tool for certain applications because of its small size, high sequence specificity and ability to generate relatively large del
Externí odkaz:
https://doaj.org/article/1f2a67d8d44f4f13aea3f0e74c9dfa2b
Autor:
Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout, Raymond Kaempfer
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation. We report that this RNA-mediated ne
Externí odkaz:
https://doaj.org/article/a21711e43d92478496d8b395fce71a1b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 43-51 (2022)
CRISPR-Cas12a is an alternative class 2 gene editing tool that may cause less off-target effects than the original Cas9 system. We have previously demonstrated that Cas12a attack with a single CRISPR RNA (crRNA) can neutralize all infectious HIV in a
Externí odkaz:
https://doaj.org/article/9160fa332f334bf2b4f280b9e7a6580b
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-4 (2021)
Abstract Zhang et al. (Proc Natl Acad Sci 118:e2105968118, 2021) recently reported that SARS-CoV-2 RNA can be retrotranscribed and integrated into the DNA of human cells by the L1 retrotransposon machinery. This phenomenon could cause persistence of
Externí odkaz:
https://doaj.org/article/c484fc54dfd3451b9f34f47774ab7bab
Autor:
Mouraya Hussein, Zaria Andrade dos Ramos, Monique A. Vink, Pascal Kroon, Zhenghao Yu, Luis Enjuanes, Sonia Zuñiga, Ben Berkhout, Elena Herrera-Carrillo
Publikováno v:
Viruses, Vol 15, Iss 3, p 686 (2023)
The current SARS-CoV-2 pandemic forms a major global health burden. Although protective vaccines are available, concerns remain as new virus variants continue to appear. CRISPR-based gene-editing approaches offer an attractive therapeutic strategy as
Externí odkaz:
https://doaj.org/article/59219288dce5426d90e49cd60efb91f1
Autor:
Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O. Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, Carine Van Lint
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 103985- (2022)
Summary: Background: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing a
Externí odkaz:
https://doaj.org/article/b64342c7f9c945c392341ed58313d142
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1563 (2023)
Human immunodeficiency virus (HIV) infections and HIV-induced acquired immunodeficiency syndrome (AIDS) continue to represent a global health burden. There is currently no effective vaccine, nor any cure, for HIV infections; existing antiretroviral t
Externí odkaz:
https://doaj.org/article/8bd43bd048ad4d74846d0dd5403e8db7
There are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the latest findings on the replication of these human retroviruses. This book is unique in that there has been no comparable bo
Autor:
Alexander O Pasternak, Jelmer Vroom, Neeltje A Kootstra, Ferdinand WNM Wit, Marijn de Bruin, Davide De Francesco, Margreet Bakker, Caroline A Sabin, Alan Winston, Jan M Prins, Peter Reiss, Ben Berkhout, The Co-morBidity in Relation to Aids (COBRA) Collaboration
Publikováno v:
eLife, Vol 10 (2021)
Background: It remains unclear whether combination antiretroviral therapy (ART) regimens differ in their ability to fully suppress human immunodeficiency virus (HIV) replication. Here, we report the results of two cross-sectional studies that compare
Externí odkaz:
https://doaj.org/article/7a0e3e84da5a40f19a902a05307fda50