Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity.

Autor: Smirnova AO; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia.; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Miroshnichenkova AM; Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates., Belyaeva LD; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Kelmanson IV; Department of Biomolecular Sciences and Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Lebedev YB; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia., Mamedov IZ; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Chudakov DM; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates.; Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia.; Central European Institute of Technology, Masaryk University, Brno, Czechia., Komkov AY; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates.; Dmitry Rogachev National Medical and Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Sep 07; Vol. 14, pp. 1245175. Date of Electronic Publication: 2023 Sep 07 (Print Publication: 2023).