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Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans.

Autor: Sharma RP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Burgers EJ; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Beltman JB; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 Aug 25; Vol. 15 (9). Date of Electronic Publication: 2023 Aug 25.

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.

Autor: Urbanus J; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Cosgrove J; Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005, Paris, France., Beltman JB; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Elhanati Y; Memorial Sloan Kettering Cancer Center, New York, USA., Moral RA; Department of Mathematics and Statistics, Maynooth University, Maynooth, Ireland., Conrad C; Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005, Paris, France., van Heijst JW; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Tubeuf E; Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005, Paris, France., Velds A; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Kok L; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Merle C; Institut Curie, Laboratory of Genetics and Developmental Biology, PSL Research University, INSERM U934, CNRS UMR3215, Paris, France., Magnusson JP; Department of Bioengineering, Stanford University, Stanford, USA., Guyonnet L; Cytometry Platform, Institut Curie, 75005, Paris, France., Frisén J; Department of Cell and Molecular Biology, Karolinska Institute, Solna, Sweden., Fre S; Institut Curie, Laboratory of Genetics and Developmental Biology, PSL Research University, INSERM U934, CNRS UMR3215, Paris, France., Walczak AM; Laboratoire de Physique de l'École Normale Supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, Paris, France., Mora T; Laboratoire de Physique de l'École Normale Supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, Paris, France., Jacobs H; Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Schumacher TN; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. t.schumacher@nki.nl.; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands. t.schumacher@nki.nl., Perié L; Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005, Paris, France. leila.perie@curie.fr.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 17; Vol. 14 (1), pp. 2184. Date of Electronic Publication: 2023 Apr 17.

High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors.

Autor: van der Stel W; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg, 55, 2333 CC, Leiden, The Netherlands., Yang H; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg, 55, 2333 CC, Leiden, The Netherlands., le Dévédec SE; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg, 55, 2333 CC, Leiden, The Netherlands., van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg, 55, 2333 CC, Leiden, The Netherlands., Beltman JB; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg, 55, 2333 CC, Leiden, The Netherlands., Danen EHJ; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg, 55, 2333 CC, Leiden, The Netherlands. e.danen@lacdr.leidenuniv.nl.

Publikováno v: Cell biology and toxicology [Cell Biol Toxicol] 2023 Apr; Vol. 39 (2), pp. 415-433. Date of Electronic Publication: 2022 May 04.