Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Beloglazova Ng"'
Autor:
Martin M. Fabani, Vladimir V. Sil'nikov, Nikolai N. Polushin, Valentin V. Vlassov, Elena V. Bichenkova, Beloglazova Ng, Marina A. Zenkova, Kenneth T. Douglas
Publikováno v:
Nucleic Acids Research. 32:3887-3897
Antisense oligonucleotide conjugates, bearing constructs with two imidazole residues, were synthesized using a precursor-based technique employing post-synthetic histamine functionalization of oligonucleotides bearing methoxyoxalamido precursors at t
Publikováno v:
Molecular Biology. 36:581-588
A method has been suggested for the synthesis of conjugates of oligodeoxyribonucleotides with chemical constructs mimicking the ribonuclease A active center for directed fragmentation of RNA. The method is based on sequential addition of a linker gro
Autor:
Marina A. Zenkova, Petiuk Va, Vladimir N. Silnikov, Konevets Da, Vlasov Vv, N. L. Mironova, Beloglazova Ng
Publikováno v:
Molecular Biology. 36:869-873
Kinetic parameters of cleavage of CpA and UpA sequences in an oligoribonucleotide under the action of artificial ribonuclease ABL3C1 were measured. The compounds were built of RNA-binding domain B, catalytic fragment C, linker L3 comprising 3 methyle
Autor:
Beloglazova Ng, Vladimir N. Silnikov, Marina A. Zenkova, Ilya V. Sulimenkov, Valentin V. Vlassov, Gennadiy V. Shishkin, Dmitrii A. Konevetz, Irene E. Beck
Publikováno v:
Tetrahedron. 55:503-512
Small mimics of the ribonuclease active centre were synthesized by conjugating imidazole residues to a dicationic compound. These compounds were shown to cleave tRNA under physiological conditions. The compounds provide new probes for the investigati
Autor:
Nikolai N. Polushin, Martin M. Fabani, Elena V. Bichenkova, Vladimir V. Sil'nikov, Beloglazova Ng, Marina A. Zenkova, Valentin V. Vlassov
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Journal of Nucleic Acids
Journal of Nucleic Acids
Design of site-selective artificial ribonucleases (aRNases) is one of the most challenging tasks in RNA targeting. Here, we designed and studied oligonucleotide-based aRNases containingmultipleimidazole residues in the catalytic part and systematical
Autor:
Georgy A. Nevinsky, Dmitry O. Zharkov, Alexander A. Ishchenko, Konstantin V. Starostin, Beloglazova Ng, Oleg O. Kirpota, Vitaly I. Yamkovoy, Kenneth T. Douglas
X-ray analysis of enzyme-DNA interactions is very informative in revealing molecular contacts, but provides neither quantitative estimates of the relative importance of these contacts nor information on the relative contributions of specific and nons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d42ef2efe1ac4bdf9ce3c55a202d671
https://europepmc.org/articles/PMC521659/
https://europepmc.org/articles/PMC521659/
Publikováno v:
FEBS letters. 481(3)
An oligonucleotide conjugate bearing a chemical construct mimicking the catalytic center of ribonuclease A has been designed and studied. The conjugate efficiently cleaves yeast tRNAPhe at a single site adjacent to the target complementary sequence.
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Akademický článek
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