Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Bellur Seetharam"'
Autor:
Giuseppe Scalabrino, Seema Kalra, Bellur Seetharam, Daniela Veber, Rajiv Ahuja, Shakuntla Seetharam, Elena Mutti
Publikováno v:
Archives of Biochemistry and Biophysics. 463:128-132
Total gastrectomy (TG) causes cobalamin (Cbl) deficiency followed by increases in tumor necrosis factor (TNF)-α levels in the spinal cord (SC) of the rat. In order to understand how Cbl deficiency may influence cell Cbl transport, we have measured b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f615ad70c978645bb4ad9a688fc4dc
https://doi.org/10.1016/j.abb.2007.03.011
https://doi.org/10.1016/j.abb.2007.03.011
Publikováno v:
The Journal of Physiology. 581:457-466
Cells that are metabolically active and in a high degree of differentiation and proliferation require cobalamin (Cbl: vitamin B(12)) and they obtain it from the circulation bound to transcobalamin (TC) via the transcobalamin receptor (TC-R). This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d144fc3b8fff65677551c100d099c916
https://doi.org/10.1113/jphysiol.2007.129171
https://doi.org/10.1113/jphysiol.2007.129171
Publikováno v:
The Journal of Physiology. 556:623-635
Transcobalamin (TC) has been cloned and used for studying its gene expression in the rat. TC mRNA is distributed widely in adult rat tissues, but at different levels (kidney > liver > lung > yolk sac > intestine > heart > brain > spleen > muscle). TC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5faa95756aa5a92f83aa56c8a15533e2
https://doi.org/10.1113/jphysiol.2003.058727
https://doi.org/10.1113/jphysiol.2003.058727
Publikováno v:
Expert Reviews in Molecular Medicine. 5:1-18
The primary function of cobalamin (Cbl; vitamin B12) is the formation of red blood cells and the maintenance of a healthy nervous system. Before cells can utilise dietary Cbl, the vitamin must undergo cellular transport using two distinct receptor-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ad610556b3426090397f333ac51da8
https://doi.org/10.1017/s1462399403006422
https://doi.org/10.1017/s1462399403006422
Autor:
Raghunatha R. Yammani, Mukut Sharma, Shakuntla Seetharam, Nancy M. Dahms, Bellur Seetharam, John E. Moulder
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 283:R339-R346
The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated. Albuminuria was evident as immunoblot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49165da95f05c7f460670c67ed4b335
https://doi.org/10.1152/ajpregu.00752.2001
https://doi.org/10.1152/ajpregu.00752.2001
Autor:
Ronald W. Grane, Ana M. Gamero, Judith A. Drazba, Barbara S. Jacobs, Kevin A. Carnevale, Joseph A. Bauer, Sally Dabney, Daniel J. Lindner, Bellur Seetharam, Daniel J. Smith, Bei H. Morrison
Publikováno v:
CancerSpectrum Knowledge Environment. 94:1010-1019
Background The ubiquitous plasma membrane transcobalamin II receptor (TC II-R) mediates uptake of cobalamin (Cbl; vitamin B12), an essential micronutrient. Tumors often require more Cbl than normal tissue, and increased Cbl uptake may result from inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed397e9b0421771b786790ad65eeedcd
https://doi.org/10.1093/jnci/94.13.1010
https://doi.org/10.1093/jnci/94.13.1010
Autor:
Kia Saiean, Jeanne Emmons, William L. Berger, Majed Abu-Hajir, Sotirios Vasilopoulos, David G. Binion, Bellur Seetharam
Publikováno v:
Journal of Clinical Gastroenterology. 33:132-136
BACKGROUND Elevated plasma total homocysteine (tHcy) is associated with a higher risk of thrombosis. Crohn's disease (CD) is associated with hypercoagulability of undefined etiology. We investigated tHcy in patients with CD and its relationship with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3f295068e23bc52390799c2b246780
https://doi.org/10.1097/00004836-200108000-00008
https://doi.org/10.1097/00004836-200108000-00008
Publikováno v:
The Journal of Nutrition. 129:1761-1764
Recent studies have isolated and characterized human gastric intrinsic factor (IF) and transcobalamin II (TC II) genes, whose products mediate the import of cobalamin (Cbl; Vitamin B-12) across cellular plasma membranes. Analyses of cDNA and genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c43826330b66d1bbb62caf01ce8a82d
https://doi.org/10.1093/jn/129.10.1761
https://doi.org/10.1093/jn/129.10.1761
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 277:G506-G514
We have analyzed the transport of newly synthesized mannose 6-phosphate (Man-6- P)-bearing proteins (i.e., lysosomal enzymes) in the polarized human colon adenocarcinoma cell line, Caco-2, by subjecting filter-grown cells to a pulse-chase labeling pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68aae9f7590ffc44ffa675fea825540
https://doi.org/10.1152/ajpgi.1999.277.3.g506
https://doi.org/10.1152/ajpgi.1999.277.3.g506
Autor:
Bellur Seetharam
Publikováno v:
Annual Review of Nutrition. 19:173-195
▪ Abstract Dietary cobalamin (Cbl) (vitamin B12) is utilized as methyl-Cbl and the coenzyme 5′-deoxyadenosyl Cbl by cells of the body that have the enzymes methionine synthase and methyl malonyl CoA mutase, which convert homocysteine to methionin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5beb8d92ec8f0b84e9517d687d395073
https://doi.org/10.1146/annurev.nutr.19.1.173
https://doi.org/10.1146/annurev.nutr.19.1.173