Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality.

Autor: Bell BI; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine, Bronx, New York., Velten C; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Pennock M; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Kang M; New York Proton Center, New York, New York., Tanaka KE; Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine, Bronx, New York., Selvaraj B; New York Proton Center, New York, New York., Bookbinder A; New York Proton Center, New York, New York., Koba W; Department of Radiology, Albert Einstein College of Medicine, Bronx, New York., Vercellino J; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine, Bronx, New York., English J; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine, Bronx, New York., Małachowska B; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Pandey S; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Duddempudi PK; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Yang Y; New York Proton Center, New York, New York; Departments of Medical Physics and Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Shajahan S; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Hasan S; New York Proton Center, New York, New York., Choi JI; New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Simone CB 2nd; New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Yang WL; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York., Tomé WA; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York., Lin H; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; New York Proton Center, New York, New York; Departments of Medical Physics and Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Guha C; Departments of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York; Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine, Bronx, New York. Electronic address: cguhamd@gmail.com.

Publikováno v: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Sep 18. Date of Electronic Publication: 2024 Sep 18.

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome.

Autor: Vercellino J; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA., Małachowska B; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA., Kulkarni S; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Bell BI; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA., Shajahan S; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA., Shinoda K; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Eichenbaum G; Johnson & Johnson, Office of the Chief Medical Officer, New Brunswick, NJ, USA.; Bioconvergent Health, LLC, Purchase, NY, USA., Verma AK; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA., Ghosh SP; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Yang WL; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA., Frenette PS; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA., Guha C; Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. cguhamd@gmail.com.; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA. cguhamd@gmail.com.; Bioconvergent Health, LLC, Purchase, NY, USA. cguhamd@gmail.com.

Publikováno v: Stem cell research & therapy [Stem Cell Res Ther] 2024 Apr 29; Vol. 15 (1), pp. 123. Date of Electronic Publication: 2024 Apr 29.

Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers.

Autor: Dreyfuss AD; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States., Velalopoulou A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States., Avgousti H; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States., Bell BI; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States., Verginadis II; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 Oct 12; Vol. 12, pp. 920867. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2022).

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression.

Autor: Verginadis II; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Avgousti H; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Monslow J; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Skoufos G; Department of Electrical and Computer Engineering, University of Thessaly, Volos, Greece.; Hellenic Pasteur Institute, Athens, Greece., Chinga F; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kim K; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Leli NM; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Karagounis IV; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bell BI; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, USA., Velalopoulou A; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Salinas CS; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wu VS; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li Y; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA., Ye J; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA., Scott DA; Cancer Metabolism Core, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Osterman AL; Cancer Metabolism Core, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Sengupta A; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weljie A; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Huang M; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhang D; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fan Y; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Radaelli E; Department of Pathobiology, School of Veterinary Medicine, Comparative Pathology Core, University of Pennsylvania, Philadelphia, PA, USA., Tobias JW; Penn Genomic Analysis Core, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rambow F; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Karras P; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Marine JC; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Xu X; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hatzigeorgiou AG; Department of Electrical and Computer Engineering, University of Thessaly, Volos, Greece.; Hellenic Pasteur Institute, Athens, Greece.; DIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece., Ryeom S; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Diehl JA; Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Fuchs SY; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. costas.koumenis@pennmedicine.upenn.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2022 Jun; Vol. 24 (6), pp. 940-953. Date of Electronic Publication: 2022 Jun 02.

Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation.

Autor: Bell BI; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Koduri S; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Salas Salinas C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Monslow J; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ben-Josef E; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Verginadis II; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: vioannis@pennmedicine.upenn.edu.

Publikováno v: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2019 Mar 01; Vol. 103 (3), pp. 719-727. Date of Electronic Publication: 2018 Oct 15.