Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.

Autor: Yan B; Departments of Biochemistry & Molecular Biology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4Z6, Canada.; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, China., Belke D; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Gui Y; Departments of Biochemistry & Molecular Biology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4Z6, Canada., Chen YX; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Jiang ZS; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, China. zsjiang2005@163.com., Zheng XL; Departments of Biochemistry & Molecular Biology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4Z6, Canada. xlzheng@ucalgary.ca.

Publikováno v: Cell death discovery [Cell Death Discov] 2023 Dec 15; Vol. 9 (1), pp. 456. Date of Electronic Publication: 2023 Dec 15.

Increased Ca ²⁺ Transient Underlies RyR2-Related Left Ventricular Noncompaction.

Autor: Ni M; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Li Y; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Wei J; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).; School of Medicine, Northwest University, Xi 'an, China (J.W.)., Song Z; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Wang H; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Yao J; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Chen YX; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Belke D; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Estillore JP; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Wang R; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.)., Vallmitjana A; Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona, Spain (A.V., R.B.)., Benitez R; Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona, Spain (A.V., R.B.).; Institut de Recerca Sant Joan de Déu (IRSJD), Barcelona, Spain (R.B.)., Hove-Madsen L; Biomedical Research Institute Barcelona IIBB-CSIC, IIB Sant Pau and CIBERCV, Hospital de Sant Pau, Barcelona, Spain (L.H.-M.)., Feng W; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla (W.F., J.C.)., Chen J; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla (W.F., J.C.)., Roston TM; Division of Pediatric Cardiology, Department of Pediatrics (T.M.R., S.S.), University of British Columbia, Vancouver, Canada., Sanatani S; Division of Pediatric Cardiology, Department of Pediatrics (T.M.R., S.S.), University of British Columbia, Vancouver, Canada., Lehman A; Department of Medical Genetics (A.L.), University of British Columbia, Vancouver, Canada., Chen SRW; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Publikováno v: Circulation research [Circ Res] 2023 Jul 07; Vol. 133 (2), pp. 177-192. Date of Electronic Publication: 2023 Jun 16.

Acellular biomaterial modulates myocardial inflammation and promotes endogenous mechanisms of postinfarct cardiac repair.

Autor: Vasanthan V; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Shim HB; Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Teng G; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Belke D; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Svystonyuk D; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Deniset JF; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Fedak PWM; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: paul.fedak@gmail.com.

Publikováno v: The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2023 Mar; Vol. 165 (3), pp. e122-e140. Date of Electronic Publication: 2021 Dec 28.

Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis.

Autor: Sun J; Departments of Biochemistry and Molecular Biology and Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, China., Belke D; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Gui Y; Departments of Biochemistry and Molecular Biology and Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Chen YX; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Zhou S; Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, China. zhoushenghua@csu.edu.cn., Zheng XL; Departments of Biochemistry and Molecular Biology and Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. xlzheng@ucalgary.ca.

Publikováno v: Cell death discovery [Cell Death Discov] 2023 Feb 07; Vol. 9 (1), pp. 49. Date of Electronic Publication: 2023 Feb 07.

Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm.

Autor: Jadli AS; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Ballasy NN; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Gomes KP; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Mackay CDA; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Meechem M; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Wijesuriya TM; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Belke D; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.; Section of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Thompson J; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Fedak PWM; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.; Section of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Patel VB; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.; Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 08; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 08.