Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Belinda Yau"'
Autor:
Alexis Diaz-Vegas, Kristen C. Cooke, Harry B. Cutler, Belinda Yau, Stewart W.C. Masson, Dylan Harney, Oliver K. Fuller, Meg Potter, Søren Madsen, Niamh R. Craw, Yiju Zhang, Cesar L. Moreno, Melkam A. Kebede, G. Gregory Neely, Jacqueline Stöckli, James G. Burchfield, David E. James
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101983- (2024)
Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum of anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models of insulin resistance
Externí odkaz:
https://doaj.org/article/d604aeab742c4b69b1c6b31c83faedfb
Autor:
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108707- (2024)
Externí odkaz:
https://doaj.org/article/e31a11c153864f3ab3262542aac210c3
Autor:
Le May Thai, Liam O’Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A. Kebede, Robert Brink, Gregory J. Cooney, Katharine M. Irvine, Samuel N. Breit, Tri G. Phan, Alexander Swarbrick, Trevor J. Biden
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106477- (2023)
Summary: We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes of M1 (inflammation) versus M2 (tissue remodeling) polarization. Unde
Externí odkaz:
https://doaj.org/article/f164ff5bf0454edab4a24997c1c6486a
Autor:
Amanda E Brandon, Lewin Small, Tuong-Vi Nguyen, Eurwin Suryana, Henry Gong, Christian Yassmin, Sarah E Hancock, Tamara Pulpitel, Sophie Stonehouse, Letisha Prescott, Melkam A Kebede, Belinda Yau, Lake-Ee Quek, Greg M Kowalski, Clinton R Bruce, Nigel Turner, Gregory J Cooney
Publikováno v:
eLife, Vol 11 (2022)
Obesity is generally associated with insulin resistance in liver and muscle and increased risk of developing type 2 diabetes, however there is a population of obese people that remain insulin sensitive. Similarly, recent work suggests that mice fed h
Externí odkaz:
https://doaj.org/article/db007dc4da554290aad890aa013d0767
Autor:
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103099- (2021)
Summary: Pancreatic islets are essential for maintaining physiological blood glucose levels, and declining islet function is a hallmark of type 2 diabetes. We employ mass spectrometry-based proteomics to systematically analyze islets from 9 genetic o
Externí odkaz:
https://doaj.org/article/6eb4cfcc46fb42ea84ae3296431c3254
Autor:
Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101219- (2021)
Externí odkaz:
https://doaj.org/article/c65a636f3f0148fa8389b7f22f55d0e5
Autor:
Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 83-94 (2019)
Objective: Insulin suppresses adipose tissue lipolysis after a meal, playing a key role in metabolic homeostasis. This is mediated via the kinase Akt and its substrate phosphodiesterase 3B (PDE3B). Once phosphorylated and activated, PDE3B hydrolyses
Externí odkaz:
https://doaj.org/article/89f28921dd844bddadf5ec401d3824cf
Autor:
Sook Hyun Chung, Weiyong Shen, Kathryn C. Davidson, Alice Pébay, Raymond C. B. Wong, Belinda Yau, Mark Gillies
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Dysfunction of retinal glial cells, particularly Müller cells, has been implicated in several retinal diseases. Despite their important contribution to retinal homeostasis, a specific way to differentiate retinal glial cells from human pluripotent s
Externí odkaz:
https://doaj.org/article/0d0dd87d52a74f51afd2275bf393ab8b
Autor:
Belinda Yau, Melkam A. Kebede
Publikováno v:
Metabolites, Vol 11, Iss 11, p 786 (2021)
This Special Issue, Islet Biology and Metabolism, was intended as a collection of studies highlighting the importance of the pancreatic islet—in both form and function—to our growing understanding of metabolic physiology and disease [...]
Externí odkaz:
https://doaj.org/article/ecfe54c5b0b5484d95f1d395e442b566
Publikováno v:
Metabolites, Vol 11, Iss 8, p 515 (2021)
The pancreatic β-cell is purpose-built for the production and secretion of insulin, the only hormone that can remove glucose from the bloodstream. Insulin is kept inside miniature membrane-bound storage compartments known as secretory granules (SGs)
Externí odkaz:
https://doaj.org/article/5014ae975e1449f29e091478b50ecb3f