Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Belinda S. Akpa"'
Autor:
Andrew E. Blanchard, Debsindhu Bhowmik, Zachary Fox, John Gounley, Jens Glaser, Belinda S. Akpa, Stephan Irle
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract The vast size of chemical space necessitates computational approaches to automate and accelerate the design of molecular sequences to guide experimental efforts for drug discovery. Genetic algorithms provide a useful framework to incremental
Externí odkaz:
https://doaj.org/article/657d1801ec52459d824b47834dcb2517
Autor:
Nicolas Barbera, Sara T. Granados, Carlos Guillermo Vanoye, Tatiana V. Abramova, Danielle Kulbak, Sang Joon Ahn, Alfred L. George, Jr., Belinda S. Akpa, Irena Levitan
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104329- (2022)
Summary: Cholesterol is a major regulator of multiple types of ion channels. Although there is increasing information about cholesterol binding sites, the molecular mechanisms through which cholesterol binding alters channel function are virtually un
Externí odkaz:
https://doaj.org/article/418e7545d4254d19b60eb0bc326bea15
Autor:
Andrew Blanchard, Debsindhu Bhowmik, Zachary Fox, John Gounley, Jens Glaser, Belinda S Akpa, Stephan Irle
The vast size of chemical space necessitates computational approaches to automate and accelerate the design of molecular sequences to guide experimental efforts for drug discovery. Genetic algorithms provide a useful framework to incrementally genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dcdf26cafb3f97637e852d1c0118e0
https://doi.org/10.26434/chemrxiv-2022-lh8kl-v2
https://doi.org/10.26434/chemrxiv-2022-lh8kl-v2
Publikováno v:
Drugs in R&D
Introduction Intravenous lipid emulsions (ILE) have been credited for successful resuscitation in drug intoxication cases where other cardiac life-support methods have failed. However, inter-individual variability can function as a confounder that ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b68fd32c0a21ac573a1c1f037501014
http://europepmc.org/articles/PMC8363697
http://europepmc.org/articles/PMC8363697
Publikováno v:
Forensic Science and Humanitarian Action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d16bdf2535a6cf842ba7d23807bc37
https://doi.org/10.1002/9781119482062.ch23
https://doi.org/10.1002/9781119482062.ch23
Publikováno v:
Current opinion in plant biology. 64
To ensure optimal utilization and bioavailability, iron uptake, transport, subcellular localization, and assimilation are tightly regulated in plants. Herein, we examine recent advances in our understanding of cellular responses to Fe deficiency. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943f6e31852597ceca7d49416003e204
https://pubmed.ncbi.nlm.nih.gov/34839201
https://pubmed.ncbi.nlm.nih.gov/34839201
Publikováno v:
Biophysical Journal. 115:1264-1280
Cholesterol is a major regulator of multiple types of ion channels, but the specific mechanisms and the dynamics of its interactions with the channels are not well understood. Kir2 channels were shown to be sensitive to cholesterol through direct int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f560f074d3c8c0df6c214c8e211e2ad
https://doi.org/10.1016/j.bpj.2018.07.041
https://doi.org/10.1016/j.bpj.2018.07.041
Autor:
Chinnaswamy Tiruppathi, Papasani V. Subbaiah, Elizabeth LeMaster, Belinda S. Akpa, Michael Cho, Dev K. Singh, Dheeraj Soni, Irena Levitan, Evgeny Berdyshev, Manuela A.A. Ayee, Nicolas Barbera, Tzu-Pin Shentu, Irina Bronova
Publikováno v:
Biophysical Journal. 112:325-338
The influence of two bioactive oxidized phospholipids on model bilayer properties, membrane packing, and endothelial cell biomechanics was investigated computationally and experimentally. The truncated tail phospholipids, 1-palmitoyl-2-(5-oxovaleroyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea95e030b89fd07eaa77e687e92bb0e
https://doi.org/10.1016/j.bpj.2016.12.002
https://doi.org/10.1016/j.bpj.2016.12.002
Autor:
Michael W. Martynowycz, Richard B. van Breemen, David Braun, Anne I. Boullerne, Guy L. Weinberg, Kinga Lis, Sergey Kalinin, Kathy Kowal, Zane Hauck, David Gidalevitz, Ivan Kuzmenko, Manuela A.A. Ayee, Kyle Ware, Israel Rubinstein, Sergey V. Brodsky, Douglas L. Feinstein, Belinda S. Akpa, Natalia Marangoni
Publikováno v:
Annals of the New York Academy of Sciences. 1374:111-122
Superwarfarins were developed following the emergence of warfarin resistance in rodents. Compared to warfarin, superwarfarins have much longer half-lives and stronger affinity to vitamin K epoxide reductase and therefore can cause death in warfarin-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::637f59c5f79a0af39ad184636630c0ee
https://doi.org/10.1111/nyas.13085
https://doi.org/10.1111/nyas.13085
Publikováno v:
Biophysical Journal. 118:556a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a36ccdf604cb5a1b7f08fbea33219e8
https://doi.org/10.1016/j.bpj.2019.11.3037
https://doi.org/10.1016/j.bpj.2019.11.3037