Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Belinda M. Abbott"'
Autor:
Ayeshah A. Rosdah, Belinda M. Abbott, Christopher G. Langendorf, Yali Deng, Jia Q. Truong, Helen M. M. Waddell, Naomi X. Y. Ling, William J. Smiles, Lea M. D. Delbridge, Guei-Sheung Liu, Jonathan S. Oakhill, Shiang Y. Lim, Jessica K. Holien
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes. Despite being the most widely used Drp1 inhibitor, the spec
Externí odkaz:
https://doaj.org/article/81d43f7ed5984ba3b02b0644c4d9b73f
Autor:
Luke F. Duncan, Geqing Wang, Olga V. Ilyichova, Martin J. Scanlon, Begoña Heras, Belinda M. Abbott
Publikováno v:
Molecules, Vol 24, Iss 20, p 3756 (2019)
A fragment-based drug discovery approach was taken to target the thiol-disulfide oxidoreductase enzyme DsbA from Escherichia coli (EcDsbA). This enzyme is critical for the correct folding of virulence factors in many pathogenic Gram-negative bacteria
Externí odkaz:
https://doaj.org/article/70b926ff64a74ac39dda7e4e62d76854
Autor:
Emily RR Mackie, Andrew S Barrow, Rebecca M Christoff, Belinda M Abbott, Anthony R Gendall, Tatiana P Soares da Costa
Publikováno v:
eLife, Vol 11 (2022)
Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects of herbicide-resistant weeds. We recently developed the first herbicidal inhibitors of lysine biosynthesis, which provi
Externí odkaz:
https://doaj.org/article/cbc58527ee934f6ab656dd0d1580b3ac
Autor:
Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini
Publikováno v:
eLife, Vol 10 (2021)
Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide targe
Externí odkaz:
https://doaj.org/article/4a54238d54044027a2091d81d099209c
Autor:
Ayeshah A. Rosdah, Belinda M. Abbott, Christopher G. Langendorf, Yali Deng, Jia Q. Truong, Helen M. M. Waddell, Naomi X. Y. Ling, William J. Smiles, Lea M. D. Delbridge, Guei-Sheung Liu, Jonathan S. Oakhill, Shiang Y. Lim, Jessica K. Holien
Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes. Despite being the most widely used Drp1 inhibitor, the specificity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a9619ddb93dfb9fcff13ce685136a5
Autor:
Tatiana P. Soares da Costa, Jessica A. Wyllie, Chamodi K. Ghardi, Mark D. Hulett, Belinda M. Abbott, J. Mark Sutton, Matthew A. Perugini
Antibiotic resistance represents one of the biggest threats to global health. While several of our current antibiotics target the peptidoglycan within the bacterial cell wall, only a fraction of its components has been explored for antibiotic develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ead2ad9ca9cd5cce4ee391d1b7c042
https://doi.org/10.1101/2022.02.10.480023
https://doi.org/10.1101/2022.02.10.480023
Autor:
Benjamin J. Richards, Jason A. Glab, George W. Mbogo, Darani Dahanayake, Brian J. Smith, Hamsa Puthalakath, Belinda M. Abbott
Publikováno v:
Bioorganic chemistry. 120
Chronic activation of beta-adrenergic receptors by the sympathetic nervous system results in the apoptosis of cardiomyocytes. Due to the inability of cardiomyocytes to regenerate, this can result in heart failure. Upregulation of the pro-apoptotic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4455bcd4f4a3250819adb6f1f3a1b285
https://pubmed.ncbi.nlm.nih.gov/35124512
https://pubmed.ncbi.nlm.nih.gov/35124512
Author response: Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants
Autor:
Rebecca M. Christoff, Santosh Panjikar, Anthony R. Gendall, Jessica A Wyllie, Tatiana P. Soares da Costa, Matthew A. Perugini, Mark D. Hulett, Cody J Hall, Saadi Bayat, Belinda M. Abbott
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931d7859e77a063e95fc7a1d31ab34a1
https://doi.org/10.7554/elife.69444.sa2
https://doi.org/10.7554/elife.69444.sa2
Autor:
Jessica A Wyllie, Rebecca M. Christoff, Belinda M. Abbott, Matthew A. Perugini, Cody J Hall, Santosh Panjikar, Anthony R. Gendall, Mark D. Hulett, Saadi Bayat, Tatiana P. Soares da Costa
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dbcf7781d6074dda0891c75ff8745e
https://elifesciences.org/articles/69444
https://elifesciences.org/articles/69444