Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Belinda L. Spillings"'
Autor:
Belinda L. Spillings, Johnson Mak
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102672- (2023)
Summary: Prior to receptor engagement, a specific, non-electrostatic glycan-glycan interaction between viral particles and host cells may lengthen the dwell time of the virus at the cellular surface, thereby facilitating subsequent virus entry. Here,
Externí odkaz:
https://doaj.org/article/a43f7a40359f40c7a9d6dd65947ac36c
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102673- (2023)
Summary: Glycan-glycan interactions between viral particles and host cells may lengthen the dwell time of the virus on the cell surface to facilitate cellular receptor engagement. Here, we present a protocol for visualizing glycan-mediated binding be
Externí odkaz:
https://doaj.org/article/8764e1de67ea474db4c15c1b4b64de59
Calcium Contributes to Polarized Targeting of HIV Assembly Machinery by Regulating Complex Stability
Autor:
Chandan Kishor, Belinda L. Spillings, Johana Luhur, Corinne A. Lutomski, Chi-Hung Lin, William J. McKinstry, Christopher J. Day, Michael P. Jennings, Martin F. Jarrold, Johnson Mak
Publikováno v:
JACS Au, Vol 2, Iss 2, Pp 522-530 (2022)
Externí odkaz:
https://doaj.org/article/386c1c4b964d496ea183fa41ea201b64
Autor:
Christopher J. Day, Rachael L. Hardison, Belinda L. Spillings, Jessica Poole, Joseph A. Jurcisek, Johnson Mak, Michael P. Jennings, Jennifer L. Edwards
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Transmission of HIV across the mucosal surface of the female reproductive tract to engage subepithelial CD4-positive T cells is not fully understood. Cervical epithelial cells express complement receptor 3 (CR3) (integrin αMβ2 or CD11b/CD1
Externí odkaz:
https://doaj.org/article/26d8314ea5da4c688c440ec560c6d217
Autor:
Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.
Externí odkaz:
https://doaj.org/article/2b06afb56d02402cb0d88feb912f1af0
Autor:
Michael P. Jennings, Christopher J. Day, Freda E.-C. Jen, Thomas Haselhorst, Patrice Guillon, Larissa Dirr, Benjamin Bailly, Belinda L. Spillings, Johnson Mak, Mark von Itzstein
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
mBio
mBio
SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.
Se
Se
Autor:
Christopher J. Day, Ainslie Calcutt, Belinda L. Spillings, Fan Fan, Johnson Mak, Laetitia Hattingh, Sharareh Eskandari, Holly A. Saffran, Danielle I. Stanisic, Jamie-Lee Mills, Ahmed O. Shalash, Michael F. Good, Manisha Pandey, Ailin Lepletier, D. Lorne Tyrrell, James T Williams, John Gerrard, Victoria Ozberk, Istvan Toth, Michael A. Joyce, Mariusz Skwarczynski, Michael P. Jennings
Publikováno v:
Clinical & Translational Immunology
Clinical & Translational Immunology, 10(3):e1260
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Clinical & Translational Immunology, 10(3):e1260
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Objectives A major COVID‐19 vaccine strategy is to induce antibodies that prevent interaction between the Spike protein's receptor‐binding domain (RBD) and angiotensin‐converting enzyme 2 (ACE2). These vaccines will also induce T‐cell respons
Autor:
Belinda L. Spillings, Christopher J. Day, Albert Garcia-Minambres, Anupriya Aggarwal, Nicholas D. Condon, Thomas Haselhorst, Damian F.J. Purcell, Stuart G. Turville, Jennifer L. Stow, Michael P. Jennings, Johnson Mak
Publikováno v:
Cell Reports. 38:110296
Here, we present ultrastructural analyses showing that incoming HIV are captured near the lymphocyte surface in a virion-glycan-dependent manner. Biophysical analyses show that removal of either virion- or cell-associated N-glycans impairs virus-cell
Autor:
Maureen Coetzee, Oliver R. Wood, Basil D. Brooke, Richard H. Hunt, Lizette L. Koekemoer, Belinda L. Spillings
Publikováno v:
African Entomology. 22:636-642
Malaria vector control by indoor residual spraying (IRS) in South Africa currently relies on the use of DDT to control pyrethroid-resistant populations of the major malaria vector Anopheles funestus. Pyrethroid resistance in An. funestus in South Afr
Autor:
Belinda L. Spillings, John Chiphwanya, Maureen Coetzee, Lizette L. Koekemoer, Basil D. Brooke, Richard H. Hunt
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 81:510-515
The major malaria vector Anopheles funestus belongs to a group of morphologically similar species that are commonly distinguished from one another through the use of chromosomal and molecular techniques. Indoor resting collections of mosquitoes from