The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.

Autor: Molly K Clifton, Belinda J Westman, Sock Yue Thong, Mitchell R O'Connell, Michael W Webster, Nicholas E Shepherd, Kate G Quinlan, Merlin Crossley, Gerd A Blobel, Joel P Mackay

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e106011 (2014)

FOG1 is a transcriptional regulator that acts in concert with the hematopoietic master regulator GATA1 to coordinate the differentiation of platelets and erythrocytes. Despite considerable effort, however, the mechanisms through which FOG1 regulates

Externí odkaz: https://doaj.org/article/6dfd3650942b47ce96da391ba8c4dabf

The Nucleolus under Stress

Autor: Saskia Hutten, Séverine Boulon, Angus I. Lamond, Belinda J. Westman, François-Michel Boisvert

Publikováno v: Molecular Cell
Molecular Cell; Vol 40

Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08646eafdc45ff77ebb8abb4a9edbe0f
https://doi.org/10.1016/j.molcel.2010.09.024

The C-terminal Domain of Eos Forms a High Order Complex in Solution

Autor: Belinda J. Westman, Jose Perdomo, Joel P. Mackay, Merlin Crossley, Margaret Sunde

Publikováno v: Journal of Biological Chemistry. 278:42419-42426

Ikaros family transcription factors play important roles in the control of hematopoiesis. Family members are predicted to contain up to six classic zinc fingers that are arranged into N- and C-terminal domains. The N-terminal domain is responsible fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9405541e57a561f4ae86dd435610a39b
https://doi.org/10.1074/jbc.m306817200

Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control

Autor: Christophe Charron, Xavier Manival, Céline Verheggen, Belinda J. Westman, Marie Eve Chagot, Heinrich Leonhardt, Angus I. Lamond, Séverine Boulon, Yasmeen Ahmad, Marie Hallais, Christiane Branlant, Jonathan Bizarro, Bérengère Pradet-Balade, Edouard Bertrand, Bruno Charpentier, Franck Vandermoere

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2014, 207 (4), pp.463-480. 〈10.1083/jcb.201404160〉
Journal of Cell Biology, Rockefeller University Press, 2014, 207 (4), pp.463-480. ⟨10.1083/jcb.201404160⟩
The Journal of Cell Biology

During small nucleolar ribonucleoprotein complex assembly, a pre-snoRNP complex consisting only of protein components forms first, followed by displacement of the ZNHIT3 subunit when C/D snoRNAs bind and dynamic loading and unloading of RuvBL AAA+ AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a47ac7571e44d3181b0c8b14bc9eb56
https://hal.univ-lorraine.fr/hal-01453204

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

Autor: Federico Pelisch, Eduardo Arzt, Belinda J. Westman, Guillermo Risso, Jimena Druker, Anabella Srebrow, Ezequiel Petrillo, Juan Gerez, Angus I. Lamond, Ignacio E. Schor, Manuel Javier Muñoz

Publikováno v: Proc. Natl. Acad. Sci. U. S. A. 2010;107(37):16119-16124
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Protein modification by conjugation of small ubiquitin-related modifier (SUMO) is involved in diverse biological functions, such as transcription regulation, subcellular partitioning, stress response, DNA damage repair, and chromatin remodeling. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8aaec80ab5cdce4b315f73ba06b642
https://pubmed.ncbi.nlm.nih.gov/20805487