Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Belinda J, Michell"'
Autor:
Nancy C. Hancock, Siew Yeen Chai, Michael W. Parker, Jessica K. Holien, S.J. Hermans, David B. Ascher, Craig J. Morton, Belinda J. Michell
Publikováno v:
Protein Science. 24:190-199
Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined the crystal structure of human IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67736010f83b22a2b754e1fc5acaaca
https://doi.org/10.1002/pro.2604
https://doi.org/10.1002/pro.2604
Autor:
Belinda J. Michell, Christine A. Seers, Susanne C. Feil, Keith J. Cross, Michael W. Parker, Michael A. Gorman, Eric C. Reynolds, N. Laila Huq
Publikováno v:
Protein Science. 24:162-166
The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95d9938e31a37644af094f2611190f0
https://doi.org/10.1002/pro.2589
https://doi.org/10.1002/pro.2589
Autor:
Matthew J. Watt, Rohan Steel, Belinda J. Michell, Sheena Wee, Sebastian B. Jørgensen, Bruce E. Kemp, Nicolas Dzamko, Johathan S Oakhill, S. Lance Macaulay, Gregory R. Steinberg, James G. Ryall, Jonathan D. Schertzer, Z-P Chen, Gordon S. Lynch
Publikováno v:
The Journal of Physiology. 586:5819-5831
The activation of AMP-activated protein kinase (AMPK) and phosphorylation/inhibition of acetyl-CoA carboxylase 2 (ACC2) is believed to be the principal pathway regulating fatty acid oxidation. However, during exercise AMPK activity and ACC Ser-221 ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1c247946c828d88f813665dad19fec
https://doi.org/10.1113/jphysiol.2008.159814
https://doi.org/10.1113/jphysiol.2008.159814
Autor:
Bryce J. W. van Denderen, Bruce E. Kemp, Tristan J. Iseli, Belinda J. Michell, Sheena Wee, Michael F. Bailey, Lee A. Witters, Mark R. Walter, David Stapleton, S. Lance Macaulay, Frosa Katsis, Laura A. Castelli, Jonathan S. Oakhill
Publikováno v:
Journal of Biological Chemistry. 283:4799-4807
AMP-activated protein kinase (AMPK) plays multiple roles in the body's overall metabolic balance and response to exercise, nutritional stress, hormonal stimulation, and the glucose-lowering drugs metformin and rosiglitazone. AMPK consists of a cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a4eea2b96d96fd738981babf883700d
https://doi.org/10.1074/jbc.m708298200
https://doi.org/10.1074/jbc.m708298200
Autor:
Gregory R. Steinberg, Mark A. Febbraio, David Carling, Sofianos Andrikopoulos, Bruce E. Kemp, Andrew L. Carey, Cem Z. Görgün, Gökhan S. Hotamisligil, Barbara C Fam, Joseph Proietto, Belinda J. Michell, Matthew J. Watt, Thomas W.H. Kay, Bryce J. W. van Denderen
Publikováno v:
Cell Metabolism. 4(6):465-474
Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c296bb14ebd34d47ec774bc836c55b
Publikováno v:
Neuromuscular Disorders. 16:337-346
Calcineurin activity is essential for successful skeletal muscle regeneration in young mdx mice and in wild type mice following myotoxic injury and cryodamage. In mature myofibres of adult mdx mice, calcineurin stimulation can ameliorate the dystroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cee2453e78b89981f623f84a51c390a
https://doi.org/10.1016/j.nmd.2006.03.003
https://doi.org/10.1016/j.nmd.2006.03.003
Publikováno v:
The Journal of Physiology. 561:861-870
To investigate the effect of exercise on protein kinase C (PKC) activity and localization in human skeletal muscle, eight healthy men performed cycle ergometer exercise for 40 min at 76 +/- 1% the peak pulmonary O(2) uptake , with muscle samples obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e332937bc701241291f04fea82e8d5eb
https://doi.org/10.1113/jphysiol.2004.075549
https://doi.org/10.1113/jphysiol.2004.075549
Autor:
Jinah Hwang, Bruce E. Kemp, Michelle C. Sykes, Hazel Lum, Belinda J. Michell, Hanjoong Jo, Yong Chool Boo
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 283:H1819-H1828
Shear stress stimulates nitric oxide (NO) production by phosphorylating endothelial NO synthase (eNOS) at Ser1179in a phosphoinositide-3-kinase (PI3K)- and protein kinase A (PKA)-dependent manner. The eNOS has additional potential phosphorylation sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b6df5bfc920972cd721b2ba240218b
https://doi.org/10.1152/ajpheart.00214.2002
https://doi.org/10.1152/ajpheart.00214.2002
Autor:
David M. Rodman, Kai Xun Li, Grzegorz Sowa, Michelle I. Lin, Jason Fontana, Belinda J. Michell, Bruce E. Kemp, David Fulton, Jean-Philippe Gratton, William C. Sessa
Publikováno v:
Journal of Biological Chemistry. 277:4277-4284
The subcellular localization of endothelial nitric-oxide synthase (eNOS) is critical for optimal coupling of extracellular stimulation to nitric oxide production. Because eNOS is activated by Akt-dependent phosphorylation to produce nitric oxide (NO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8eeba18a5c5f7ef98f37f1aebdd16ef
https://doi.org/10.1074/jbc.m106302200
https://doi.org/10.1074/jbc.m106302200
Autor:
Michael A, Gorman, Christine A, Seers, Belinda J, Michell, Susanne C, Feil, N Laila, Huq, Keith J, Cross, Eric C, Reynolds, Michael W, Parker
Publikováno v:
Protein science : a publication of the Protein Society. 24(1)
The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4ae6e1bad5a8d96d1f23ff7b8874a8e
https://pubmed.ncbi.nlm.nih.gov/25327141
https://pubmed.ncbi.nlm.nih.gov/25327141