Výsledky vyhledávání - "Belinda E. Hetzler"

Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery

Autor: Ismail A. Ahmed, Jing-Jing Liu, Krystyna A. Gieniec, Chloe J. Bair-Marshall, Ayomiposi B. Adewakun, Belinda E. Hetzler, Christopher J. Arp, Latika Khatri, Gilles C. Vanwalleghem, Alec T. Seidenberg, Pamela Cowin, Dirk Trauner, Moses V. Chao, Felicity M. Davis, Richard W. Tsien, Robert C. Froemke

Publikováno v: Ahmed, I A, Liu, J-J, Gieniec, K A, Bair-Marshall, C J, Adewakun, A B, Hetzler, B E, Arp, C J, Khatri, L, Vanwalleghem, G C, Seidenberg, A T, Cowin, P, Trauner, D, Chao, M V, Davis, F M, Tsien, R W & Froemke, R C 2022, ' Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery ', bioRxiv . https://doi.org/10.1101/2022.11.10.516001

Oxytocin is a neuropeptide critical for maternal physiology and social behavior, and is thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and neurocognitive importance of oxytocin signaling, methods are lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0a6861deeb949ce47fc03514083ca2
https://pure.au.dk/portal/da/publications/optopharmacological-tools-for-precise-spatiotemporal-control-of-oxytocin-signaling-in-the-central-nervous-system-and-periphery(d2feb2a8-e9b0-4e22-ad93-fdadae6a0bd7).html

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A concise synthesis of tetrodotoxin

Autor: David B. Konrad, Klaus-Peter Rühmann, Hiroyasu Ando, Belinda E. Hetzler, Nina Strassner, Kendall N. Houk, Bryan S. Matsuura, Dirk Trauner

Publikováno v: Science (New York, N.Y.). 377(6604)

Tetrodotoxin (TTX) is a neurotoxic natural product that is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and a celebrated target of synthetic chemistry. Here, we present a stereoselective synthesis of TTX that proceeds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b2c2eef394a87dff7d338833be9256
https://pubmed.ncbi.nlm.nih.gov/35862530

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Photoswitchable Serotonins for Optical Control of the 5‐HT 2A Receptor**

Autor: Johannes Morstein, Giovanna Romano, Belinda E. Hetzler, Ambrose Plante, Caleb Haake, Joshua Levitz, Dirk Trauner

Publikováno v: Angewandte Chemie International Edition. 61

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adfe21b6b8ec9edaaa4a4bb8f78658f
https://doi.org/10.1002/anie.202117094

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Natural product anticipation through synthesis

Autor: Belinda E. Hetzler, Dirk Trauner, Andrew L. Lawrence

Publikováno v: Nat Rev Chem
Hetzler, B E, Trauner, D & Lawrence, A L 2022, ' Natural product anticipation through synthesis ', Nature Reviews Chemistry, vol. 6, no. 3, pp. 170-181 . https://doi.org/10.1038/s41570-021-00345-7

Natural product synthesis remains one of the most vibrant and intellectually rewarding areas of chemistry, although the justifications for pursuing it have evolved over time. In the early years, the emphasis lay on structure elucidation and confirmat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efbb870d3c054546ab112817d2c349a
https://europepmc.org/articles/PMC9899497/

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Photoswitchable Serotonins for Optical Control of the 5-HT

Autor: Johannes, Morstein, Giovanna, Romano, Belinda E, Hetzler, Ambrose, Plante, Caleb, Haake, Joshua, Levitz, Dirk, Trauner

Publikováno v: Angew Chem Int Ed Engl

Serotonin receptors play central roles in neuromodulation and are critical drug targets for psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to greatly enhance our understanding of the spatiotemporal dynamics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35351d39cde098f8813baa9d90599c42
https://pubmed.ncbi.nlm.nih.gov/34989082

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An Efficient Synthesis of Tetrodotoxin

Autor: Belinda E. Hetzler, David B. Konrad, Peter Ruehmann, Bryan S. Matsuura, Hiroyasu Ando, Dirk Trauner

Tetrodotoxin (TTX) is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and one of the most celebrated targets of synthetic chemistry. Here, we present a stereoselective synthesis of TTX that proceeds in 22 steps starting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b489ba4b32c8d0413603413bdd97405
https://doi.org/10.33774/chemrxiv-2021-xkftp

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Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor

Autor: Belinda E. Hetzler, Giovanna Romano, Joshua Levitz, Dirk Trauner, Johannes Morstein, Caleb Haake, Ambrose Plante

The serotonin receptor family of G protein-coupled receptors (GPCRs) and ligand-gated ion channels play central roles in neuromodulation and are critical drug targets for the treatment of psychiatric disorders. Optical control of serotonin receptor s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bbedb597eeefe0195f04125955dad0
https://doi.org/10.33774/chemrxiv-2021-cq4r6

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Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

Autor: David B. Konrad, Ehud Y. Isacoff, Belinda E. Hetzler, Prashant Donthamsetti, Dirk Trauner, Zhu Fu

Publikováno v: Journal of the American Chemical Society, vol 143, iss 24
Journal of the American Chemical Society

G protein-coupled receptors (GPCRs) are the most common targets of drug discovery. However, the similarity between related GPCRs combined with the complex spatiotemporal dynamics of receptor activation in vivo has hindered drug development. Photophar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c98f30636255b31e62249f1b1c93780
https://escholarship.org/uc/item/4r70147g

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