Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Belinda Cancilla"'
Autor:
Marcus M. Fischer, V. Pete Yeung, Fiore Cattaruzza, Rajaa Hussein, Wan-Ching Yen, Christopher Murriel, James W. Evans, Gilbert O’Young, Alayne L. Brunner, Min Wang, Jennifer Cain, Belinda Cancilla, Ann Kapoun, Timothy Hoey
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins that enhance Wnt signaling and RSPO2 and RSPO3 gene fusions have been reported in CR
Externí odkaz:
https://doaj.org/article/97a62eb300e14b3a9c293d6e18060cfa
Autor:
Alison H. Joly, Yu-Chien Chou, Justin Lesch, Lillian Lee, Stefan Engst, A. Douglas Laird, Andrew You, Jessica Orf, Belinda Cancilla, Frauke Bentzien, Felix Chu, Fawn Qian, Peiwen Yu, Yongchang Shi, Kyoko Yamaguchi, Jenny Tan, Jason Chen, F. Michael Yakes
PDF file - 104KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cd3621fbfa51d438f48142646da225
https://doi.org/10.1158/1535-7163.22496638.v1
https://doi.org/10.1158/1535-7163.22496638.v1
Autor:
Alison H. Joly, Yu-Chien Chou, Justin Lesch, Lillian Lee, Stefan Engst, A. Douglas Laird, Andrew You, Jessica Orf, Belinda Cancilla, Frauke Bentzien, Felix Chu, Fawn Qian, Peiwen Yu, Yongchang Shi, Kyoko Yamaguchi, Jenny Tan, Jason Chen, F. Michael Yakes
The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) is important for cell growth, survival, and motility and is functionally linked to the signaling pathway of VEGF, which is widely recognized as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c0549987b6953fbcc1b2686b81a276
https://doi.org/10.1158/1535-7163.c.6535348
https://doi.org/10.1158/1535-7163.c.6535348
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen
Table S1: OMP-59R5 binding data as assessed by surface plasmon resonance (Biacore); Table S2. Histopathology of human pancreatic tumors; Table S3. Effect of anti-Notch2/3 antibody OMP-59R5 in combination with gemcitabine on growth of pancreatic xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf498724cd8f0c5646ff30984a2c9c4
https://doi.org/10.1158/1078-0432.22458093
https://doi.org/10.1158/1078-0432.22458093
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen
Purpose: The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of Notch signaling has been reported in several human tumor types. In this report, we describe the development of an antibody, OMP-59R5 (tarextumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f473b99c67334f0815470d792e6624
https://doi.org/10.1158/1078-0432.c.6523824.v1
https://doi.org/10.1158/1078-0432.c.6523824.v1
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen
Figure S1A. Binding affinities of OMP-59R5 to human (h) Notch1-4 receptors; Figure S1B. Alignment of the EGF repeats 10-15 of Notch2 and 9-14 of Notch3 from human (h), cynomolgus monkey (cyno), and mouse (m); Figure S2. Human NOTCH1, NOTCH2 and NOTCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f59c2b422fb81b4b510586fa10a689b
https://doi.org/10.1158/1078-0432.22458096.v1
https://doi.org/10.1158/1078-0432.22458096.v1
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Supplemental figure legends also include brief methods where appropriate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c92ef1c6e992c263c2057d6a7459f78
https://doi.org/10.1158/0008-5472.22410083.v1
https://doi.org/10.1158/0008-5472.22410083.v1
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a2dd884372d990c2aeb1d5180b91e4
https://doi.org/10.1158/0008-5472.c.6507911
https://doi.org/10.1158/0008-5472.c.6507911
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Supplemental Tables include a list and brief description of xenograft models used in the study, the RSPO1-4 gene expression profile and beta-catenin activation status of all xenograft models, and the microarray analysis for 4 CRC xenograft models aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c673aa921f31eb42807e17eb99f932
https://doi.org/10.1158/0008-5472.22410080.v1
https://doi.org/10.1158/0008-5472.22410080.v1
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Supplemental figures include the RSPO gene expression analysis for CRC models, the in vitro testing of anti-RSPO antibodies on RSPO-negative tumors, the IHC analysis of anti-RSPO3+chemo-treated ovarian tumors, the LGR, ZNRF3, and RNF43 gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19afe2511ee33ae67efef1d503d78862
https://doi.org/10.1158/0008-5472.22410086.v1
https://doi.org/10.1158/0008-5472.22410086.v1