Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Belinda Cairns"'
Autor:
Yoshiko Akamatsu, Hamsell M. Alvarez, Diane Hollenbaugh, Debra T. Chao, David B. Powers, Charles M. Forsyth, Josue Samayoa, Mengli Xiong, Vivian Zhao, Belinda Cairns, Mien Sho, Li Zhou, Enrico DiGiammarino, Siu Sze Tan, Melvin Fox, Archana Thakur, Zhenghai Xu, Sun K. Ho
Efficacy and pharmacodynamics analysis of anti-CD137 in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a80e5785dfed25dfb55c2ef1b50324
https://doi.org/10.1158/1535-7163.22520673.v1
https://doi.org/10.1158/1535-7163.22520673.v1
Autor:
Yoshiko Akamatsu, Hamsell M. Alvarez, Diane Hollenbaugh, Debra T. Chao, David B. Powers, Charles M. Forsyth, Josue Samayoa, Mengli Xiong, Vivian Zhao, Belinda Cairns, Mien Sho, Li Zhou, Enrico DiGiammarino, Siu Sze Tan, Melvin Fox, Archana Thakur, Zhenghai Xu, Sun K. Ho
Binding kinetics of anti-CD137 measured by Biacore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adee88711469c8b488cfa7f95e6071f
https://doi.org/10.1158/1535-7163.22520667.v1
https://doi.org/10.1158/1535-7163.22520667.v1
Autor:
Yoshiko Akamatsu, Hamsell M. Alvarez, Diane Hollenbaugh, Debra T. Chao, David B. Powers, Charles M. Forsyth, Josue Samayoa, Mengli Xiong, Vivian Zhao, Belinda Cairns, Mien Sho, Li Zhou, Enrico DiGiammarino, Siu Sze Tan, Melvin Fox, Archana Thakur, Zhenghai Xu, Sun K. Ho
CD137 (TNFRSF9, 4-1BB) agonist antibodies (mAb) have demonstrated potent antitumor activity with memory response while causing hepatotoxicity in mouse models. In clinical trials, the degrees of liver toxicity of anti-CD137 vary from grade 4 transamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793ce8580dc06cb588737a5a4dcecf4c
https://doi.org/10.1158/1535-7163.c.6542724
https://doi.org/10.1158/1535-7163.c.6542724
Autor:
Brian J. Park, Austin K. Mattox, Daniel Clayburgh, Mihir Patel, R. Bryan Bell, Bevan Yueh, Rom Leidner, Hong Xiao, Marcus Couey, Shiting Li, Tingting Qin, Maureen A. Sartor, Belinda Cairns, Tracy MacDonough, Kyle Halliwill, Daniel Deschler, Derrick T. Lin, William C. Faquin, Peter M. Sadow, Sara I. Pai
Publikováno v:
Oral oncology. 135
PD-L1 testing guides therapeutic decision-making for head and neck squamous cell carcinoma (HNSCC). We sought to understand whether chemoradiation therapy (CRT) influences the PD-L1 combined positive score (CPS) and other biomarkers of response to im
Autor:
Mien Sho, Sun K. Ho, Josue Samayoa, Hamsell M. Alvarez, Archana Thakur, Belinda Cairns, Mengli Xiong, Diane Hollenbaugh, Debra Chao, Yoshiko Akamatsu, Li Zhou, Enrico L. Digiammarino, Charles M. Forsyth, Melvin Fox, Siu sze Tan, Vivian Zhao, Zhenghai Xu, David B. Powers
Publikováno v:
Molecular Cancer Therapeutics. 19:1040-1051
CD137 (TNFRSF9, 4-1BB) agonist antibodies (mAb) have demonstrated potent antitumor activity with memory response while causing hepatotoxicity in mouse models. In clinical trials, the degrees of liver toxicity of anti-CD137 vary from grade 4 transamin
Publikováno v:
Neurological research, vol 34, iss 4
Tang, XN; Cairns, B; Kim, JY; & Yenari, MA. (2012). NADPH oxidase in stroke and cerebrovascular disease. Neurological Research, 34(4), 338-345. doi: 10.1179/1743132812Y.0000000021. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6df1z6gv
Tang, XN; Cairns, B; Kim, JY; & Yenari, MA. (2012). NADPH oxidase in stroke and cerebrovascular disease. Neurological Research, 34(4), 338-345. doi: 10.1179/1743132812Y.0000000021. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6df1z6gv
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) was originally identified in immune cells as playing an important microbicidal role. In stroke and cerebrovascular disease, inflammation is increasingly being recognized as contributin
Autor:
Manish R. Patel, Dong M. Shin, Lori J. Wirth, Rom Leidner, Jong Chul Park, Mihir R. Patel, Kyle Halliwell, Francesco M. Marincola, Daniel R. Clayburgh, Derrick T. Lin, Debra Chao, Belinda Cairns, Bevan Yueh, Josue Samayoa, Richard Bryan Bell, Tolga Turan, Nabil F. Saba, Sara I. Pai, Naomi Fujioka, Daniel E. H. Afar
Publikováno v:
Journal of Clinical Oncology. 36:6052-6052
6052Background: Head and neck squamous cell carcinoma (HNSCC) patients have a 16-25% response rate to single agent immune checkpoint inhibitors (ICI). Prognostic biomarkers to ICIs are needed to id...
Publikováno v:
Neuroscience. 154:556-562
Inflammation following ischemic stroke is known to contribute to injury. NADPH oxidase (NOX) is a major enzyme system originally studied in immune cells that leads to superoxide (O•-) generation. Apocynin is a NOX inhibitor that has been studied as
Autor:
Gregory M, Hayes, Belinda, Cairns, Zoia, Levashova, Lawrence, Chinn, Myra, Perez, Jan-Willem, Theunissen, Sindy, Liao-Chan, Abel, Bermudez, Mark R, Flory, Karl J, Schweighofer, Edward, H van der Horst
Publikováno v:
American journal of translational research. 7(6)
Soft tissue sarcoma (STS) is a heterogenous tumor arising from the embryonic mesoderm represented by approximately 50 histological subtypes. Effective therapeutic intervention is lacking for recurrent, late stage and metastatic disease. CD39, a cell-
Autor:
Kenneth J. Hillan, Thinh Pham, Belinda Cairns, Trent Landon, Adrian M. Jubb, Franklin Peale, Philip Quirke, Gretchen Frantz, J Burwick
Publikováno v:
The Journal of Pathology. 200:577-588
The accuracy and reliability of in situ studies may be compromised by qualitative interpretations. Quantitation imposes a greater degree of objectivity, is more reproducible, and facilitates the clarity of definitions. The aim of this study was to va