Výsledky vyhledávání - "Belinda Akpeng"

Identification of the murine H-2Db and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes

Autor: Austin Mattox, Eiichi Ishida, Tzyy Choou Wu, Benjamin Yang, Sara I. Pai, Shiwen Peng, Anca M. Barbu, James A. Burns, Simon R. Best, Jessica Jeang, Belinda Akpeng, Chien Fu Hung

Publikováno v: Cancer Immunology, Immunotherapy. 65:261-271

Recurrent respiratory papillomatosis is caused by human papillomavirus (HPV) infection, most commonly types 6 (HPV-6) and 11 (HPV-11). Due to failed host immune responses, HPV is unable to be cleared from the host, resulting in recurrent growth of HP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27192204aab0ae3fdc22cedf9b40513
https://doi.org/10.1007/s00262-016-1793-x

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Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens

Autor: Nicholas S. Wilson, Sylvia Dietrich, Randi Gombos, Ana M. Martín González, Robert Stein, Lukasz Swiech, David Savitsky, Ben A. Croker, Benjamin Morin, Jennifer Buell, Mariana Manrique, Antoine Tanne, Jeremy D. Waight, Christine Brittsan, Dhan Chand, Belinda Akpeng, Thomas Horn

Publikováno v: Cancer cell. 33(6)

Summary The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to therapeutic activity has been extensively studied. For example, F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fb5e3d0625d63436d08e3f84d077d6
https://pubmed.ncbi.nlm.nih.gov/29894690

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Xenograft Model for Therapeutic Drug Testing in Recurrent Respiratory Papillomatosis

Autor: Justin A. Bishop, Julie Ahn, Sara I. Pai, Simon R. Best, Belinda Akpeng

Publikováno v: Annals of Otology, Rhinology & Laryngology. 124:110-115

Objective: Identifying effective treatment for papillomatosis is limited by a lack of animal models, and there is currently no preclinical model for testing potential therapeutic agents. We hypothesized that xenografting of papilloma may facilitate i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62958b312532a7bdb1739c8d7a41209d
https://doi.org/10.1177/0003489414546400

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Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay

Autor: Kevin D. Frick, Jeremy D. Richmon, Belinda Akpeng, Justin A. Bishop, William H. Westra, Zhen Gooi, Takenori Ogawa, Patrick K. Ha, Diarmuid Coughlan, Sara I. Pai, David F. Smith, Christine G. Gourin, Zahra Maleki, Wayne M. Koch, Nishant Agrawal

Publikováno v: Oral Oncology. 50:600-604

Summary Objective A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5a672d9622fbe39b991403ce831909
https://doi.org/10.1016/j.oraloncology.2014.02.011

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Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma

Autor: Belinda Akpeng, Suzanne L. Topalian, Drew M. Pardoll, Jeremy D. Richmon, Janis M. Taube, Hao Wang, William H. Westra, Sara I. Pai, Tullia C. Bruno, Geoffrey D. Young, Sofia Lyford-Pike, Shiwen Peng, Justin A. Bishop, Lieping Chen, Charles G. Drake

Publikováno v: Cancer research. 73(6)

Human papillomavirus-associated head and neck squamous cell carcinomas (HPV-HNSCC) originate in the tonsils, the major lymphoid organ that orchestrates immunity to oral infections. Despite its location, the virus escapes immune elimination during mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5ff49327904c56df50ce9e714f2206
https://pubmed.ncbi.nlm.nih.gov/23288508

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Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine

Autor: Belinda Akpeng, Shiwen Peng, Sofia Lyford-Pike, Annie A. Wu, T-C Wu, John R. Saunders, Chien Fu Hung, Drew Hannaman, Sara I. Pai

Although therapeutic HPV vaccines are able to elicit systemic HPV-specific immunity, clinical responses have not always correlated with levels of vaccine-induced CD8(+) T cells in human clinical trials. This observed discrepancy may be attributable t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2a615644523466a70d11b729742bf1
https://europepmc.org/articles/PMC3543472/

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Abstract 641: Correlation of methylation status of deep surgical margins with the local reccurence of head and neck squamous cell carcinoma

Autor: Gaosong Wu, Belinda Akpeng, Julie Ahn, Xiaofei Chang, Zubair Khan, Masamichi Hayashi, Jong Lyel Roh, Wayne M. Koch, Xiufeng Li

Publikováno v: Cancer Research. 73:641-641

Background: Locoregional recurrence occurs in as many as 40% of patients undergoing surgery for head and neck squamous cell carcinoma (HNSCC). We have been focused some molecular alterations exsiting even in histologically negative surgical margins.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3133ea036d73903163934c5b1c74a21
https://doi.org/10.1158/1538-7445.am2013-641

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