Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Belinda, Whittle"'
Autor:
Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.
Externí odkaz:
https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
Autor:
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Externí odkaz:
https://doaj.org/article/76d21e2f20924475a4c47cb697a95a92
Autor:
Zuopeng Wu, Rong Liang, Thomas Ohnesorg, Vicky Cho, Wesley Lam, Walter P Abhayaratna, Paul A Gatenby, Chandima Perera, Yafei Zhang, Belinda Whittle, Andrew Sinclair, Christopher C Goodnow, Matthew Field, T Daniel Andrews, Matthew C Cook
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006067 (2016)
Most humans harbor both CD177neg and CD177pos neutrophils but 1-10% of people are CD177null, placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia. By
Externí odkaz:
https://doaj.org/article/6e78e15a6d4e4a64bb492e26851408cc
LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.
Autor:
Yan Liu, Kathleen DeBoer, David M de Kretser, Liza O'Donnell, Anne E O'Connor, D Jo Merriner, Hidenobu Okuda, Belinda Whittle, David A Jans, Athina Efthymiadis, Robert I McLachlan, Christopher J Ormandy, Chris C Goodnow, Duangporn Jamsai, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005090 (2015)
Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OA
Externí odkaz:
https://doaj.org/article/040121e1c3374ed8a427d065623bd48c
Autor:
Robert Brink, David Zahra, Jeanette E. Villanueva, Benjamin T. Porebski, Garry P. Nolan, Murray P. Cox, Carla M. Roots, Claudia Loetsch, Cecile King, Paul Z. Benitez-Aguirre, Jia Tang, Belinda Whittle, Juliana Teo, Joanna Warren, Wendy Sandoval, Marcel E. Dinger, Elisabeth K. Malle, Christopher C. Goodnow, Geeta Chaudhri, Velimir Gayevskiy, Ingrid E. Wertz, Jin Yan Yap, John B. Ziegler, Yogesh Jeelall, Keisuke Horikawa, Colin J. Jackson, Stacey N. Walters, Daniele Cultrone, Daniel Christ, Frank Schmitz, Nathan W. Zammit, Shane T. Grey, Melanie Wong, David B. Langley, Craig N. Jenne, Owen M. Siggs, Tim Wiltshire, Anselm Enders, Lewis L. Lanier, Mark J. Cowley, Matthew H. Spitzer, Wilson Phung, Stuart G. Tangye, Peter D. Mabbitt, Derek W. Abbott, Susan R. Watson, Benjamin E. Clifton, Stephen R. Daley, Alan Aderem, Paul Gray, Ashley M. Buckle, Gunasegaran Karupiah, Michiko Yamada, Edward M. Bertram, Amanda J. Russell, Maria E. Craig
Publikováno v:
Nature Immunology. 20:1299-1310
Resisting and tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here genomic analyses of anatomically modern humans, extinct Denisovan hominins and mic
Autor:
Brenda Y Han, Shuang Wu, Chuan-Sheng Foo, Robert M Horton, Craig N Jenne, Susan R Watson, Belinda Whittle, Chris C Goodnow, Jason G Cyster
Publikováno v:
eLife, Vol 3 (2014)
The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger prot
Externí odkaz:
https://doaj.org/article/ddad725609d84747b5161b6b5274b9bf
Autor:
Belinda Whittle, Reena Desai, Rama Nimmagadda, Timothy D. Handelsman, David J. Handelsman, Richard A. Anderson, Karolina Skorupskaite
Publikováno v:
Handelsman, D J, Nimmagadda, R, Desai, R, Handelsman, T D, Whittle, B, Skorupskaite, K & Anderson, R A 2021, ' Direct Measurement of Pregnanediol 3-Glucuronide (PDG) In Dried Urine Spots by Liquid Chromatography-Mass Spectrometry to Detect Ovulation ', Journal of Steroid Biochemistry and Molecular Biology . https://doi.org/10.1016/j.jsbmb.2021.105900
Background Non-invasive self-testing using an objective chemical method to detect ovulation is valuable for women planning conception, practising contraception or undergoing infertility investigations or treatment. Methods Based on luteal phase secre
Autor:
Stephen R Daley, Kristen M Coakley, Daniel Y Hu, Katrina L Randall, Craig N Jenne, Andre Limnander, Darienne R Myers, Noelle K Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa A Miosge, Geoff Sjollema, Edward M Bertram, Matthew A Field, Yunli Shao, T Daniel Andrews, Belinda Whittle, S Whitney Barnes, John R Walker, Jason G Cyster, Christopher C Goodnow, Jeroen P Roose
Publikováno v:
eLife, Vol 2 (2013)
Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear aut
Externí odkaz:
https://doaj.org/article/99a34eaaa5914ca98a046571e4a1f72a
Autor:
Georgina Caruana, Peter G Farlie, Adam H Hart, Stefan Bagheri-Fam, Megan J Wallace, Michael S Dobbie, Christopher T Gordon, Kerry A Miller, Belinda Whittle, Helen E Abud, Ruth M Arkell, Timothy J Cole, Vincent R Harley, Ian M Smyth, John F Bertram
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e55429 (2013)
Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in o
Externí odkaz:
https://doaj.org/article/4ef49950460e4f1d88f053a4f9e96464
Autor:
Moira K O'Bryan, Brett J Clark, Eileen A McLaughlin, Rebecca J D'Sylva, Liza O'Donnell, Jacqueline A Wilce, Jessie Sutherland, Anne E O'Connor, Belinda Whittle, Christopher C Goodnow, Christopher J Ormandy, Duangporn Jamsai
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003628 (2013)
Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. Disturbance of splicing regulation
Externí odkaz:
https://doaj.org/article/5e823f89f3ff43c5a2abffb7ec30fb03