Sputum lipoarabinomannan (LAM) as a biomarker to determine sputum mycobacterial load: exploratory and model-based analyses of integrated data from four cohorts

Autor: Aksana Jones, Jay Saini, Belinda Kriel, Laura E. Via, Yin Cai, Devon Allies, Debra Hanna, David Hermann, Andre G. Loxton, Gerhard Walzl, Andreas H. Diacon, Klaus Romero, Ryo Higashiyama, Yongge Liu, Alexander Berg

Publikováno v: BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-18 (2022)

Abstract Background Despite the high global disease burden of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb) infection, novel treatments remain an urgent medical need. Development efforts continue to be hampered by the reli

Externí odkaz: https://doaj.org/article/1c33dd8c2a7d407eb03ee7e006988320

Sputum lipoarabinomannan (LAM) as a biomarker to determine sputum mycobacterial load: exploratory and model-based analyses of integrated data from four cohorts

Autor: Aksana, Jones, Jay, Saini, Belinda, Kriel, Laura E, Via, Yin, Cai, Devon, Allies, Debra, Hanna, David, Hermann, Andre G, Loxton, Gerhard, Walzl, Andreas H, Diacon, Klaus, Romero, Ryo, Higashiyama, Yongge, Liu, Alexander, Berg

Publikováno v: BMC Infectious Diseases

Background Despite the high global disease burden of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb) infection, novel treatments remain an urgent medical need. Development efforts continue to be hampered by the reliance on c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fe2fea8140864ac3efa8f32d9ffffb
http://hdl.handle.net/11427/36368

Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial

Autor: Thomas J Scriba, Andrew Fiore-Gartland, Adam Penn-Nicholson, Humphrey Mulenga, Stanley Kimbung Mbandi, Bhavesh Borate, Simon C Mendelsohn, Katie Hadley, Chris Hikuam, Masooda Kaskar, Munyaradzi Musvosvi, Nicole Bilek, Steven Self, Tom Sumner, Richard G White, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T Malherbe, Razia Hassan-Moosa, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, Kesenogile Baepanye, Tshepiso Baepanye, Ken Clarke, Marelize Collignon, Audrey Dlamini, Candice Eyre, Tebogo Feni, Moogo Fikizolo, Phinda Galane, Thelma Goliath, Alia Gangat, Shirley Malefo-Grootboom, Elba Janse van Rensburg, Bonita Janse van Rensburg, Sophy Kekana, Marietjie Zietsman, Adrianne Kock, Israel Kunene, Aneessa Lakhi, Nondumiso Langa, Hilda Ledwaba, Marillyn Luphoko, Immaculate Mabasa, Dorah Mabe, Nkosinathi Mabuza, Molly Majola, Mantai Makhetha, Mpho Makoanyane, Blossom Makhubalo, Vernon Malay, Juanita Market, Selvy Matshego, Nontsikelelo Mbipa, Tsiamo Mmotsa, Sylvester Modipa, Samuel Mopati, Palesa Moswegu, Primrose Mothaga, Dorothy Muller, Grace Nchwe, Maryna Nel, Lindiwe Nhlangulela, Bantubonke Ntamo, Lawerence Ntoahae, Tedrius Ntshauba, Nomsa Sanyaka, Letlhogonolo Seabela, Pearl Selepe, Melissa Senne, MG Serake, Maria Thlapi, Vincent Tshikovhi, Lebogang Tswaile, Amanda van Aswegen, Lungile Mbata, Constance Takavamanya, Pedro Pinho, John Mdlulu, Marthinette Taljaard, Naydene Slabbert, Sharfuddin Sayed, Tanya Nielson, Ni Ni Sein, Dhineshree Govender, Tilagavathy Chinappa, Mbali Ignatia Zulu, Nonhle Bridgette Maphanga, Senzo Ralph Hlathi, Goodness Khanyisile Gumede, Thandiwe Yvonne Shezi, Jabulisiwe Lethabo Maphanga, Zandile Patrica Jali, Thobelani Cwele, Nonhlanhla Zanele Elsie Gwamanda, Celaphiwe Dlamini, Zibuyile Phindile Penlee Sing, Ntombozuko Gloria Ntanjana, Sphelele Simo Nzimande, Siyabonga Mbatha, Bhavna Maharaj, Atika Moosa, Cara-Mia Corris, Fazlin Kafaar, Hennie Geldenhuys, Angelique Kany Kany Luabeya, Justin Shenje, Natasja Botes, Susan Rossouw, Hadn Africa, Bongani Diamond, Samentra Braaf, Sonia Stryers, Alida Carstens, Ruwiyda Jansen, Simbarashe Mabwe, Roxane Herling, Ashley Veldsman, Lebohgang Makhete, Marcia Steyn, Sivuyile Buhlungu, Margareth Erasmus, Ilse Davids, Patiswa Plaatjie, Alessandro Companie, Frances Ratangee, Helen Veldtsman, Christel Petersen, Charmaine Abrahams, Miriam Moses, Xoliswa Kelepu, Yolande Gregg, Liticia Swanepoel, Nomsitho Magawu, Nompumelelo Cetywayo, Lauren Mactavie, Habibullah Valley, Elizabeth Filander, Nambitha Nqakala, Elizna Maasdorp, Justine Khoury, Belinda Kriel, Bronwyn Smith, Liesel Muller, Susanne Tonsing, Andre Loxton, Andriette Hiemstra, Petri Ahlers, Marika Flinn, Eva Chung, Michelle Chung, Alicia Sato

Publikováno v: The Lancet. Infectious Diseases

Summary Background Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7177dcad10cc3ff04cc42dbb59a97559
https://pubmed.ncbi.nlm.nih.gov/33508223

S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis

Autor: Noor Al-Hammadi, Thomas Vogl, Rosemary V. Swanson, Marcela Muñoz-Torrico, Mushtaq Ahmed, Ninecia R. Scott, Shibali Das, Nelita du Plessis, Belinda Kriel, Puthayalai Treerat, Luis Jiménez-Alvarez, Javier Rangel-Moreno, Alfredo Cruz-Lagunas, Deepak Kaushal, Gerhard Walzl, Thomas J. Scriba, Joaquín Zúñiga, Shabaana A. Khader, Smriti Mehra, Racquel Domingo-Gonzalez, Karen Bobadilla-Lozoya, Allison N. Bucsan

Publikováno v: J Clin Invest

Neutrophil accumulation is associated with lung pathology during active tuberculosis (ATB). However, the molecular mechanism or mechanisms by which neutrophils accumulate in the lung and contribute to TB immunopathology are not fully delineated. Usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ae31df118352a18206f794b2942b02
https://pubmed.ncbi.nlm.nih.gov/32134742

Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

Autor: Dolapo O. Awoniyi, Andrea Teuchert, Jayne S. Sutherland, Harriet Mayanja-Kizza, Rawleigh Howe, Adane Mihret, Andre G. Loxton, Jacob Sheehama, Desta Kassa, Amelia C. Crampin, Hazel M. Dockrell, Martin Kidd, Ida Rosenkrands, Annemieke Geluk, Tom H.M. Ottenhoff, P.L.A.M. Corstjens, Novel N. Chegou, Gerhard Walzl, Magdalena Kriel, Gian van der Spuy, Kim Stanley, Stephanus Malherbe, Shirley Mcanda, Belinda Kriel, Khutso G. Phalane, Paulin Essone, Olumuyiwa Owolabi, Abdou Sillah, Joseph Mendy, Awa Gindeh, Simon Donkor, Toyin Togun, Martin Ota, Felanji Simukonda, Alemayehu Amberbir, Femia Chilongo, Rein Houben, Atsbeha Gebrezgeabher, Getnet Mesfin, Yohannes Belay, Gebremedhin Gebremichael, Yodit Alemayehu, Marieta van der Vyver, Faustina N. Amutenya, Josefina N. Nelongo, Lidia Monye, Jacob A. Sheehama, Scholastica Iipinge, Ann Ritah Namuganga, Grace Muzanye, Mary Nsereko, Pierre Peters, Yonas Bekele, Bamlak Tessema, Lawrence Yamuah, Kees Franken, Paul L.A.M. Corstjens, Elisa M. Tjon Kon Fat, Claudia J. de Dood, Jolien J. van der Ploeg-van Schip, Claus Aagaard, Stefan H.E. Kaufmann, Maria M. Esterhuyse, Jacqueline M. Cliff

Publikováno v: Journal of infection
Journal of Infection, 73(3), 219-230. W B SAUNDERS CO LTD

Objective:\ud \ud We investigated the accuracy of host markers detected in Mtb antigen-stimulated whole blood culture supernatant in the diagnosis of TB.\ud Methods:\ud \ud Prospectively, blood from 322 individuals with presumed TB disease from six A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0841fbec9dfe5410a7510f695dedfb9
https://hdl.handle.net/11858/00-001M-0000-002B-AB4B-A21.11116/0000-0003-DDD9-0