Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting

Autor: Charles M. Manyelo, Regan S. Solomons, Candice I. Snyders, Portia M. Manngo, Hygon Mutavhatsindi, Belinda Kriel, Kim Stanley, Gerhard Walzl, Novel N. Chegou

Publikováno v: Mediators of Inflammation, Vol 2019 (2019)

Background. The diagnosis of tuberculous meningitis (TBM) especially in children is challenging. New tests are urgently needed for the diagnosis of the disease, especially in resource-limited settings. Methods. We collected cerebrospinal fluid (CSF)

Externí odkaz: https://doaj.org/article/f3317bce325142ba8b34eef234c8e54d

Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis

Autor: Ruschca Jacobs, Dolapo O. Awoniyi, Ralf Baumann, Kim Stanley, Shirley McAnda, Susanne Kaempfer, Stephanus T. Malherbe, Mahavir Singh, Gerhard Walzl, Novel N. Chegou, Magdalena Kriel, Gian van der Spuy, Andre G. Loxton, Belinda Kriel, Jayne S. Sutherland, Olumuyiwa Owolabi, Abdou Sillah, Joseph Mendy, Awa Gindeh, Simon Donkor, Toyin Togun, Martin Ota, Amelia C. Crampin, Felanji Simukonda, Alemayehu Amberbir, Femia Chilongo, Rein Houben, Desta Kassa, Atsbeha Gebrezgeabher, Getnet Mesfin, Yohannes Belay, Gebremedhin Gebremichael, Yodit Alemayehu, Marieta van der Vyver, Faustina N. Amutenya, Josefina N. Nelongo, Lidia Monye, Jacob A. Sheehama, Scholastica Iipinge, Harriet Mayanja-Kizza, Anna Ritah Namuganga, Grace Muzanye, Mary Nsereko, Pierre Peters, Rawleigh Howe, Adane Mihret, Yonas Bekele, Bamlak Tessema, Lawrence Yamuah, Tom H.M. Ottenhoff, Annemieke Geluk, Kees Franken, Jolien J. van der Ploeg-van Schip, Paul L.A.M. Corstjens, Elisa M. Tjon Kon Fat, Claudia J. de Dood, Ida Rosenkrands, Claus Aagaard, Stefan H.E. Kaufmann, Maria M. Esterhuyse, Jacqueline M. Cliff, Hazel M. Dockrell

Publikováno v: Tuberculosis, 133. CHURCHILL LIVINGSTONE
Tuberculosis 133, 102169 (2022). doi:10.1016/j.tube.2022.102169

Tuberculosis 133, 102169 (2022). doi:10.1016/j.tube.2022.102169
Published by Churchill Livingstone, Edinburgh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf317b1791015f9a14b16735ff11bff2
https://hdl.handle.net/1887/3502495

Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial

Autor: Thomas J Scriba, Andrew Fiore-Gartland, Adam Penn-Nicholson, Humphrey Mulenga, Stanley Kimbung Mbandi, Bhavesh Borate, Simon C Mendelsohn, Katie Hadley, Chris Hikuam, Masooda Kaskar, Munyaradzi Musvosvi, Nicole Bilek, Steven Self, Tom Sumner, Richard G White, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T Malherbe, Razia Hassan-Moosa, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, Kesenogile Baepanye, Tshepiso Baepanye, Ken Clarke, Marelize Collignon, Audrey Dlamini, Candice Eyre, Tebogo Feni, Moogo Fikizolo, Phinda Galane, Thelma Goliath, Alia Gangat, Shirley Malefo-Grootboom, Elba Janse van Rensburg, Bonita Janse van Rensburg, Sophy Kekana, Marietjie Zietsman, Adrianne Kock, Israel Kunene, Aneessa Lakhi, Nondumiso Langa, Hilda Ledwaba, Marillyn Luphoko, Immaculate Mabasa, Dorah Mabe, Nkosinathi Mabuza, Molly Majola, Mantai Makhetha, Mpho Makoanyane, Blossom Makhubalo, Vernon Malay, Juanita Market, Selvy Matshego, Nontsikelelo Mbipa, Tsiamo Mmotsa, Sylvester Modipa, Samuel Mopati, Palesa Moswegu, Primrose Mothaga, Dorothy Muller, Grace Nchwe, Maryna Nel, Lindiwe Nhlangulela, Bantubonke Ntamo, Lawerence Ntoahae, Tedrius Ntshauba, Nomsa Sanyaka, Letlhogonolo Seabela, Pearl Selepe, Melissa Senne, MG Serake, Maria Thlapi, Vincent Tshikovhi, Lebogang Tswaile, Amanda van Aswegen, Lungile Mbata, Constance Takavamanya, Pedro Pinho, John Mdlulu, Marthinette Taljaard, Naydene Slabbert, Sharfuddin Sayed, Tanya Nielson, Ni Ni Sein, Dhineshree Govender, Tilagavathy Chinappa, Mbali Ignatia Zulu, Nonhle Bridgette Maphanga, Senzo Ralph Hlathi, Goodness Khanyisile Gumede, Thandiwe Yvonne Shezi, Jabulisiwe Lethabo Maphanga, Zandile Patrica Jali, Thobelani Cwele, Nonhlanhla Zanele Elsie Gwamanda, Celaphiwe Dlamini, Zibuyile Phindile Penlee Sing, Ntombozuko Gloria Ntanjana, Sphelele Simo Nzimande, Siyabonga Mbatha, Bhavna Maharaj, Atika Moosa, Cara-Mia Corris, Fazlin Kafaar, Hennie Geldenhuys, Angelique Kany Kany Luabeya, Justin Shenje, Natasja Botes, Susan Rossouw, Hadn Africa, Bongani Diamond, Samentra Braaf, Sonia Stryers, Alida Carstens, Ruwiyda Jansen, Simbarashe Mabwe, Roxane Herling, Ashley Veldsman, Lebohgang Makhete, Marcia Steyn, Sivuyile Buhlungu, Margareth Erasmus, Ilse Davids, Patiswa Plaatjie, Alessandro Companie, Frances Ratangee, Helen Veldtsman, Christel Petersen, Charmaine Abrahams, Miriam Moses, Xoliswa Kelepu, Yolande Gregg, Liticia Swanepoel, Nomsitho Magawu, Nompumelelo Cetywayo, Lauren Mactavie, Habibullah Valley, Elizabeth Filander, Nambitha Nqakala, Elizna Maasdorp, Justine Khoury, Belinda Kriel, Bronwyn Smith, Liesel Muller, Susanne Tonsing, Andre Loxton, Andriette Hiemstra, Petri Ahlers, Marika Flinn, Eva Chung, Michelle Chung, Alicia Sato

Publikováno v: The Lancet. Infectious Diseases

Summary Background Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7177dcad10cc3ff04cc42dbb59a97559
https://pubmed.ncbi.nlm.nih.gov/33508223

Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting

Autor: Candice I. Snyders, Hygon Mutavhatsindi, Belinda Kriel, Gerhard Walzl, Regan Solomons, Novel N. Chegou, Charles M. Manyelo, Kim Stanley, Portia M. Manngo

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2019 (2019)

Background. The diagnosis of tuberculous meningitis (TBM) especially in children is challenging. New tests are urgently needed for the diagnosis of the disease, especially in resource-limited settings. Methods. We collected cerebrospinal fluid (CSF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bbc7fbf2f769f7f3ffedd006ebcfbc
http://europepmc.org/articles/PMC6501148

COMBINED SPECIFIC IGG – AND IGA-BASED DIAGNOSIS OF TUBERCULOSIS IN AFRICAN PRIMARY HEALTHCARE CLINIC ATTENDEES WITH SIGNS AND SYMPTOMS SUGGESTIVE OF TUBERCULOSIS

Autor: Ruschca Jacobs, Martin Kidd, Andre G. Loxton, Dolapo Olaitan Awoniyi, Novel N. Chegou, Mahavir Singh, Ralf Baumann, Gerhard Walzl, Belinda Kriel, Susanne Kaempfer

Publikováno v: BMJ Global Health. 2:A36.1-A36

Background IgG-based tests for the diagnosis of active tuberculosis disease (TB) often show a lack of specificity in TB endemic regions, which is mainly due to a high background prevalence of latent TB infection (LTBI). Here, we investigate the combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1495b89b54f1681d4bcaa977a31f0c80
https://doi.org/10.1136/bmjgh-2016-000260.94