Experimental and In Silico Analysis of TEM β-Lactamase Adaptive Evolution

Autor: Standley, Melissa, Blay, Vincent, Beleva Guthrie, Violeta, Kim, Jay, Lyman, Audrey, Moya, Andrés, Karchin, Rachel, Camps, Manel

Publikováno v: ACS infectious diseases, vol 8, iss 12

Multiple mutations often have non-additive (epistatic) phenotypic effects. Epistasis is of fundamental biological relevance but is not well understood mechanistically. Adaptive evolution, i.e., the evolution of new biochemical activities, is rich in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::df43842fda073b9ffd10e8799cfa1e07
https://escholarship.org/uc/item/0rv5j6w7

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4mutations predominantly in low-grade regions

Autor: Fujikura, Kohei, Hosoda, Waki, Felsenstein, Mattha¨us, Song, Qianqian, Reiter, Johannes G, Zheng, Lily, Beleva Guthrie, Violeta, Rincon, Natalia, Dal Molin, Marco, Dudley, Jonathan, Cohen, Joshua D, Wang, Pei, Fischer, Catherine G, Braxton, Alicia M, Noe¨, Michae¨l, Jongepier, Martine, Fernández-del Castillo, Carlos, Mino-Kenudson, Mari, Schmidt, C Max, Yip-Schneider, Michele T, Lawlor, Rita T, Salvia, Roberto, Roberts, Nicholas J, Thompson, Elizabeth D, Karchin, Rachel, Lennon, Anne Marie, Jiao, Yuchen, Wood, Laura D

Publikováno v: Gut; 2021, Vol. 70 Issue: 5 p928-939, 12p

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A probabilistic model to predict clinical phenotypic traits from genome sequencing

Autor: Violeta Beleva-Guthrie, Cheng Wang, Christopher Douville, David Neil Cooper, Grace Yeo, Hannah Carter, Sean D. Mooney, Rachel Karchin, Yun-Ching Chen, Noushin Niknafs, Peter D. Stenson, Biao Li

Publikováno v: PLoS Computational Biology
PLoS computational biology, vol 10, iss 9
PLoS Computational Biology, Vol 10, Iss 9, p e1003825 (2014)
Chen, Yun-Ching; Douville, Christopher; Wang, Cheng; Niknafs, Noushin; Yeo, Grace; Beleva-Guthrie, Violeta; et al.(2014). A probabilistic model to predict clinical phenotypic traits from genome sequencing.. PLoS computational biology, 10(9), e1003825. doi: 10.1371/journal.pcbi.1003825. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2kd4z1m4

Genetic screening is becoming possible on an unprecedented scale. However, its utility remains controversial. Although most variant genotypes cannot be easily interpreted, many individuals nevertheless attempt to interpret their genetic information.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72bfeb5469862844e9a4f689c44ef10
https://orca.cardiff.ac.uk/id/eprint/79104/1/journal.pcbi.1003825.pdf