Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Belen Joglar"'
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Akademický článek
Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors
Autor: Begoña Villar-Cheda, Antonio Dominguez-Meijide, Belen Joglar, Ana I. Rodriguez-Perez, Maria J. Guerra, Jose L. Labandeira-Garcia
Publikováno v: Neurobiology of Disease, Vol 47, Iss 2, Pp 268-279 (2012)
It has recently been shown that the dopaminergic cell loss induced by neurotoxins is enhanced by brain angiotensin II (AII) via type 1 receptors (AT1). However, the mechanisms involved in the dopaminergic degeneration and the brain inflammatory effec
Externí odkaz: https://doaj.org/article/c4eba1e33f98470092d4eb49d01832ea
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2
Glaucoma: Focus on mitochondria in relation to pathogenesis and neuroprotection
Autor: Susana del Olmo-Aguado, Claudia Núñez-Álvarez, Neville N. Osborne, Belen Joglar
Publikováno v: European Journal of Pharmacology. 787:127-133
Primary open-angle glaucoma (POAG) is a common form of glaucoma in which retinal ganglion cells (RGCs) die at varying intervals. Primary open-angle glaucoma is often associated with an increased intraocular pressure (IOP), which when reduced, can slo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f13b60c7bb7bbccf14387151cd8f1f
https://doi.org/10.1016/j.ejphar.2016.04.032
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3
Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors
Autor: Maria J. Guerra, Begoña Villar-Cheda, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez, Belen Joglar, Antonio Dominguez-Meijide
Publikováno v: Neurobiology of Disease, Vol 47, Iss 2, Pp 268-279 (2012)
It has recently been shown that the dopaminergic cell loss induced by neurotoxins is enhanced by brain angiotensin II (AII) via type 1 receptors (AT1). However, the mechanisms involved in the dopaminergic degeneration and the brain inflammatory effec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d11c56a1af950c8e5f63eb0c0ec444
http://www.sciencedirect.com/science/article/pii/S0969996112001398
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4
Cografting of carotid body cells improves the long-term survival, fiber outgrowth and functional effects of grafted dopaminergic neurons
Autor: Jose L. Labandeira-Garcia, Ana B. Muñoz-Manchado, Belen Joglar, Juan José Toledo-Aral, Jannette Rodriguez-Pallares, Javier Villadiego
Publikováno v: Regenerative Medicine. 7:309-322
Aims: A major limiting factor for cell therapy in Parkinson’s disease is that the survival of grafted dopaminergic neurons is very poor, which may be improved by administration of GDNF, for which the carotid body is a good source. Materials & metho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622cc040f24a648f8ab9c2c10a685cf4
https://doi.org/10.2217/rme.12.22
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5
Effect of inhibitors of NADPH oxidase complex and mitochondrial ATP-sensitive potassium channels on generation of dopaminergic neurons from neurospheres of mesencephalic precursors
Autor: Jose L. Labandeira-Garcia, Carmen Diaz-Ruiz, Belen Joglar, Maria J. Guerra, Juan A. Parga, Jannette Rodriguez-Pallares
Publikováno v: Developmental Dynamics. 239:3247-3259
Reactive oxygen species signaling has been suggested to regulate stem cell development. In the present study, we treated neurospheres of rat mesencephalic precursors with inhibitors of the NADPH oxidase complex and mitochondrial ATP-sensitive potassi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6440d0f6c29cef507e013bcbf3dc7fc8
https://doi.org/10.1002/dvdy.22474
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6
Location of Prorenin Receptors in Primate Substantia Nigra: Effects on Dopaminergic Cell Death
Autor: José L. Lanciego, Ana Muñoz, Jose L. Labandeira-Garcia, Rita Valenzuela, Pedro Barroso-Chinea, Begoña Villar-Cheda, Belen Joglar
Publikováno v: Journal of Neuropathology & Experimental Neurology. 69:1130-1142
Angiotensin II acts via angiotensin type 1 receptors and is a major inducer of inflammation and oxidative stress. Local renin-angiotensin systems play a major role in the development of age-related disorders in several tissues. These processes are de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102ddc0e885a43ad1b8f232b78f8cfcb
https://doi.org/10.1097/nen.0b013e3181fa0308
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7
The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease
Autor: Maria J. Guerra, Belen Joglar, Jannette Rodriguez-Pallares, Pablo Rey, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez
Publikováno v: Journal of Neurochemistry. 109:656-669
The neurotoxin MPTP reproduces most of the biochemical and pathological hallmarks of Parkinson's disease. In addition to reactive oxygen species (ROS) generated as a consequence of mitochondrial complex I inhibition, microglial NADPH-derived ROS play
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbee713c78344e5d66096996987fe8f
https://doi.org/10.1111/j.1471-4159.2009.05999.x
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8
The Mitochondrial ATP-Sensitive Potassium Channel Blocker 5-Hydroxydecanoate Inhibits Toxicity of 6-Hydroxydopamine on Dopaminergic Neurons
Autor: Juan A. Parga, Jose L. Labandeira-Garcia, Maria J. Guerra, Jannette Rodriguez-Pallares, Belen Joglar
Publikováno v: Neurotoxicity Research. 15:82-95
The neurotoxin 6-hydroxydopamine is commonly used in models of Parkinson's disease, and a potential factor in the pathogenesis of the disease. However, the mechanisms responsible for 6-hydroxydopamine-induced dopaminergic degeneration have not been t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4c34b8fe8ea956569a6e04c64c5dc3
https://doi.org/10.1007/s12640-009-9010-8
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9
Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease
Autor: Maria J. Guerra, Pablo Garrido-Gil, Belen Joglar, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez
Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 38 (2012)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Journal of Neuroinflammation
Background Several recent studies have shown that angiotensin type 1 receptor (AT1) antagonists such as candesartan inhibit the microglial inflammatory response and dopaminergic cell loss in animal models of Parkinson's disease. However, the mechanis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfc1996af242ba54474b1be6a26d078
http://www.jneuroinflammation.com/content/9/1/38
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10
Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson's disease
Autor: Maria J. Guerra, Jannette Rodriguez-Pallares, Juan A. Parga, Belen Joglar, Jose L. Labandeira-Garcia
Publikováno v: Age (Dordrecht, Netherlands). 34(4)
Recent studies have shown that renin–angiotensin system overactivation is involved in the aging process in several tissues as well as in longevity and aging-related degenerative diseases by increasing oxidative damage and inflammation. We have rece
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9dcfe16d3ba5102edca1f63fcae138
https://pubmed.ncbi.nlm.nih.gov/21713375
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