Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Belem Avila"'
Autor:
Elfatih Elzein, Kobayashi Tetsuya, Brian Stafford, Ryoko Hirakawa, Nevena Mollova, Sridharan Rajamani, Belem Avila, Catherine Smith-Maxwell, Thao Perry, Lin Wu, Jennifer Tang, Jeff Zablocki, Xiaofen Li, Wei-Qun Wang, Dmitry Koltun, Parkhill Eric Q, Robert Jiang, Arvinder Dhalla, Luiz Belardinelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3207-3211
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Publikováno v:
Organic Letters. 13:1060-1063
A number of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles were synthesized utilizing an easy and effective N,N-bond forming heterocyclization reaction. In so doing, th
Autor:
Kaushik Ghosh, Aura A. Eroy-Reveles, Pradip K. Mascharak, Belem Avila, Theodore R. Holman, Marilyn M. Olmstead
Publikováno v:
Inorganic Chemistry. 43:2988-2997
The Mn(II) and Mn(III) complexes of the pentadentate ligand N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide (PaPy3H; H is the dissociable carboxamide H), namely, [Mn(PaPy3)(H2O)]ClO4 (1) and [Mn(PaPy3)(Cl)]ClO4 (2), with bound carboxam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5976-5978
A number of (1 H -1,2,3-triazol-1-yl)benzo[ d ]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide–alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2- d ]tetrazole ( 1 ) and 2-azidobenzo[ d ]thiazole ( 2 ) starting m
Publikováno v:
ChemInform. 44
A number of (1 H -1,2,3-triazol-1-yl)benzo[ d ]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide–alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2- d ]tetrazole ( 1 ) and 2-azidobenzo[ d ]thiazole ( 2 ) starting m
Autor:
Musa Z. Nazer, Jason G. Harrison, Belem Avila, Dean J. Tantillo, Mark J. Kurth, Mohammad H. El-Dakdouki, Makhluf J. Haddadin
Publikováno v:
Tetrahedron letters. 53(48)
Indazoles and indazolones are privileged heterocycles with many biological applications, which have prompted the development of numerous methods for the construction of these heterocyclic systems.1 While the chemistries to and of 1H-indazoles are wel
Publikováno v:
ChemInform. 42
A number of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles were synthesized utilizing an easy and effective N,N-bond forming heterocyclization reaction. In so doing, th
Autor:
Michael D. Toney, Belem Avila, Mohamed H. El-Badri, Seth Dixon, Kristin T. Ziebart, Mark J. Kurth, Kathryn G. Guggenheim
Publikováno v:
Journal of medicinal chemistry. 53(9)
Chorismate-utilizing enzymes are attractive antimicrobial drug targets due to their absence in humans and their central role in bacterial survival and virulence. The structural and mechanistic homology of a group of these inspired the goal of discove
Publikováno v:
Organic Letters; Mar2011, Vol. 13 Issue 5, p1060-1063, 4p