Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

Autor: Bewley, M.A., Belchamber, K.B., Chana, K.K., Budd, R.C., Donaldson, G., Wedzicha, J.A., Brightling, C.E., Kilty, I., Donnelly, L.E., Barnes, P.J., Singh, D., Whyte, M.K., Dockrell, D.H.

Publikováno v: Bewley, M A, Belchamber, K B R, Chana, K K, Budd, R C, Donaldson, G, Wedzicha, J A, Brightling, C E, Kilty, I, Donnelly, L E, Barnes, P J, Singh, D & Whyte, M K B & Dockrell, D 2016, ' Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD ', PLoS ONE, vol. 11, no. 9, pp. e0163139 . https://doi.org/10.1371/journal.pone.0163139
PLoS ONE
Bewley, M A, Belchamber, K B R, Chana, K K, Budd, R C, Donaldson, G, Wedzicha, J A, Brightling, C E, Kilty, I, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B, Dockrell, D H & COPDMAP 2016, ' Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD ', PLoS ONE, vol. 11, no. 9, pp. e0163139 . https://doi.org/10.1371/journal.pone.0163139

Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecul

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https://www.pure.ed.ac.uk/ws/files/28576749/Whyte_M_Differential_effects....pdf