Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Belal O Al-Najjar"'
Autor:
Nurul Hanim Salin, Rahmah Noordin, Belal O Al-Najjar, Ezatul Ezleen Kamarulzaman, Muhammad Hafiznur Yunus, Izzati Zahidah Abdul Karim, Nurul Nadieya Mohd Nasim, Iffah Izzati Zakaria, Habibah A Wahab
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0225232 (2020)
Toxoplasma gondii is the etiologic agent of toxoplasmosis, a disease which can lead to morbidity and mortality of the fetus and immunocompromised individuals. Due to the limited effectiveness or side effects of existing drugs, the search for better d
Externí odkaz:
https://doaj.org/article/5d37fcfd6c814f18af45a8d6a61a9c40
Autor:
Ahmed Ismail, Fatma A. El-Shibani, Hamdoon A. Mohammed, Belal O. Al-Najjar, Amany M. Korkor, Abdulnaser Kh. Abdulkarim, Rana Said, Suliman A. Almahmoud, Ghassan M. Sulaiman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Crithmum maritimum (sea fennel), is a halophytic plant species found globally in coastal environments. This study is the first investigation into the chemical composition and biological activities of C. maritimum growing wildly in Jebel Akhd
Externí odkaz:
https://doaj.org/article/917759c4020a43ce95118cc2e949ee8a
Autor:
Hamdoon A. Mohammed, Rana Said, Manal M. Abbas, Belal O. Al-Najjar, Essam Abd-Elmoniem, Riaz A. Khan, Abdullah S. Alsohim, Suliman A. Almahmoud, Taha A. Kedra, Safia M. Shehata, Ahmed Ismail
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Ephedra alata Decne is a medicinal plant widely used in traditional medicine for the management of bronchial asthma and cancer. Phytochemical analysis and biological activities, including antioxidant and anticancer effects, were investigated
Externí odkaz:
https://doaj.org/article/5fa586ba4e8942cebdac8a4b709b440b
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-9 (2024)
Glucokinase (GK) activators are promising candidates for type 2 diabetes treatment. This study utilized structure-based pharmacophore modeling and QSAR analysis to identify novel activators. Virtual screening of a 250,000-compound library yielded eig
Externí odkaz:
https://doaj.org/article/b45f6c3722864d12a484adc3cfc358f0
Autor:
Adam A. Aboalroub, Belal O. Al-Najjar
Publikováno v:
Results in Chemistry, Vol 11, Iss , Pp 101757- (2024)
The ATP-dependent molecular chaperone, Hsp90, is crucial for the activity of hundreds of client proteins. Several of Hsp90 clients are involved in cancer cell growth and proliferation. Thus, numerous Hsp90 inhibitors have been developed to target Hsp
Externí odkaz:
https://doaj.org/article/0816700e98f84beba89cff53eb8cb0c2
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-9 (2024)
Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We synthesised a novel series of FGFR1 inhibitors bearing quinoline, quinoxalin and isoquinoline using a synthetic strategy employing a one pot reaction, yielding 2-hy
Externí odkaz:
https://doaj.org/article/30f7bdb432e446a6ad96e2a824a0cd08
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 4, Pp 662-673 (2023)
Context: Transient receptor potential vanilloid type 1 (TRPV1) is a non-specific cation channel. It is one of the most important targets in pain research. Aims: To evaluate new TRPV1 antagonists without altering body temperature. Methods: Docki
Externí odkaz:
https://doaj.org/article/7bdbac437208481b8fff36b9539b1e38
Autor:
Belal O. Al-Najjar, Fadi G. Saqallah
Publikováno v:
Molecules, Vol 28, Iss 9, p 3878 (2023)
The P2Y12 receptor is an important member of the purinergic receptor family, known for its critical role in platelet activation and thrombosis. In our previously published study, the acridinone analogue NSC618159 was identified as a potent antagonist
Externí odkaz:
https://doaj.org/article/290ca8059d5e429ea72213a3818c13c6
Publikováno v:
Balkan Medical Journal, Vol 37, Iss 4, Pp 189-195 (2020)
Background: Moringa peregrina (M. peregrina) is an edible, drought-resistant tree that is native to semi-arid countries. It is used as a painkiller in folk medicine. Aims: To study the antinociceptive effects of the leaf extract of M. peregrina in m
Externí odkaz:
https://doaj.org/article/b03ab0b40e174d11bbb91c8362ac46f0
Publikováno v:
RSC Medicinal Chemistry. 14:239-246
In silico and in vitro discovery of P2Y12 antagonists utilizing structure-based pharmacophore modelling directed by quantitative structure-activity relationship (QSAR) analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac7c6f918e675d05408cf9ddc531a5bf
https://doi.org/10.1039/d2md00285j
https://doi.org/10.1039/d2md00285j