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Androgen receptor (AR) and its splicing variant 7 (ARv7) play vital roles in the pathobiology of breast cancer (BC) but their role in the estrogen receptor-positive (ER+) type is controversial, hence, we studied the influence of the blockers of AR (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3e687414a09ccb0fb4c8856b5e82e89
https://doi.org/10.21203/rs.3.rs-2311551/v1
https://doi.org/10.21203/rs.3.rs-2311551/v1
Autor:
Belal M Ali, Hanan S El-Abhar, Ghada Mohamed, Marwa Sharaky, Samia A Shouman, Marwa Wagih Kamel
Purpose: Androgen receptor (AR) is often expressed in breast cancer, but its role in estrogen receptor positive (ER+) type is controversial. Although AR and its splicing variant 7 (ARV7) play a role in the pathobiology of breast cancer, the precise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a763e4758c8a5f061509f4f3cc11979
https://doi.org/10.21203/rs.3.rs-1420312/v1
https://doi.org/10.21203/rs.3.rs-1420312/v1
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 388:1271-1282
The antitumor activity of carbonic anhydrase (CA) inhibitors is attributed to their ability to induce a state of intracellular acidification. In fact, acidic intracellular pH was demonstrated to upregulate several tumor suppressor proteins and increa