Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bela Rajiv Patel"'
Autor:
Bela Rajiv Patel, Howard Kallender, Donna S. Cox, Lone Ottesen, Laurel M. Adams, Rajendra P. Singh
Publikováno v:
The Journal of Clinical Pharmacology. 55:1184-1192
Foretinib is a multikinase inhibitor that inhibits multiple receptor tyrosine kinases, including MET and VEGFR, with the potential for treatment of solid tumors. Hepatocellular carcinoma (HCC) pathogenesis is associated with overexpression of MET, an
Autor:
Pravin R. Jadhav, Helen Kastrissios, Wonkyung Byon, Kevin Dykstra, Nitin Mehrotra, Christoffer W. Tornøe, Nidal Al-Huniti, Bela Rajiv Patel, Yaning Wang
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
The purpose of this work was to develop a consolidated set of guiding principles for reporting of population pharmacokinetic (PK) analyses based on input from a survey of practitioners as well as discussions between industry, consulting and regulator
Autor:
Bertrand Coiffier, Mikkel Østergaard, Anton Hagenbeek, Herbert Struemper, Anders Österborg, Bela Rajiv Patel, Roxanne C. Jewell, William G. Wierda, Mark Sale
Publikováno v:
The Journal of Clinical Pharmacology. 54:818-827
Ofatumumab is a human monoclonal antibody directed at CD20 approved for treatment of chronic lymphocytic leukemia. The population pharmacokinetics of intravenous ofatumumab were characterized in patients with relapsed/refractory chronic lymphocytic l
Autor:
Theresa L. Werner, John W. Bauman, YanYan Zhou, Bela Rajiv Patel, Sunil Sharma, Kyriakos P. Papadopoulos, Amita Patnaik, Donna S. Cox, Mohammed Hamid, Drew W. Rasco, Anthony W. Tolcher, Daniel Schramek, Murali Beeram, Anita Scheuber
Publikováno v:
Cancer chemotherapy and pharmacology. 78(3)
Trametinib is a reversible, selective inhibitor of the mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and 2 (MEK2). Cardiotoxicity (congestive heart failure, decreased heart rate, left ventricular dysfunction, and hypertension) rela
Autor:
Andrea C. Haynes, Benjamin I. Andrews, Bela Rajiv Patel, Jason Witherington, Mary A. Morse, Umesh Kumar, Colin A. Campbell, Pam Gaskin, Sapna Desai, Robert Willis, Jason W. B. Cooke, Greg J. Osborne, Simon Taylor, Robert J. Watson, Terry Panchal, Alcide Perboni, Nigel Deeks, James Gray, Simon J. Dowell, Duncan S. Holmes, Rino A. Bit, Emmanuel Hubert Demont
Publikováno v:
ACS Medicinal Chemistry Letters. 2:444-449
Gilenya (fingolimod, FTY720) was recently approved by the U.S. FDA for the treatment of patients with remitting relapsing multiple sclerosis (RRMS). It is a potent agonist of four of the five sphingosine 1-phosphate (S1P) G-protein-coupled receptors
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 43(2)
The long-acting muscarinic antagonist umeclidinium (UMEC) is approved as a once-daily monotherapy and in combination with the long-acting β2 agonist vilanterol (VI) for chronic obstructive pulmonary disease. The objective of this analysis was to ass
Autor:
Mark R Slaughter, Bela Rajiv Patel, Heather L. Lloyd, Greg Whelan, Janette A. Osborne, Joanne Byrne, David Templeton, Karen Pointing, David G. Reid, Alan White, Albert L. Busza, Belinda A. Farnfield, Gemma L. Taylor, Paul D. Hockings, Sean C. Smart, Jeffrey M. Birmingham, Ana Criado-Gonzalez, Axel Krebs-Brown
Publikováno v:
Toxicology Mechanisms and Methods. 13:39-43
The use of magnetic resonance imaging (MRI) for the measurement of cardiac output parameters in anesthetized adult male beagle dogs has been validated against a widely accepted thermodilution method. Using a multislice cine gradient echo MRI method t
Autor:
April M. Barbour, Ruchira Glaser, Mindy Magee, Lee Tombs, Wenli Tao, Bela Rajiv Patel, Niki Arya, Michael J. Fossler, Bonnie C. Shaddinger
Publikováno v:
Journal of clinical pharmacology. 55(6)
A thorough QT study was conducted in healthy volunteers with losmapimod. Four treatment regimens were included: a therapeutic dose (7.5 mg BID for 5 days), a supratherapeutic dose (20 mg QD for 5 days), a positive control (400 mg moxifloxacin single
Autor:
Apurva K. Patel, Nick Carter, Khadeeja Mohamed, Emma J. Harrell, Mirna J. McDonald, Stephan Duparc, Azra Hussaini, Bela Rajiv Patel, Ann K. Miller, Justin A. Green
Publikováno v:
Journal of Clinical Pharmacology
Tafenoquine is being developed for relapse prevention in Plasmodium vivax malaria. This Phase I, single-blind, randomized, placebo- and active-controlled parallel group study investigated whether tafenoquine at supratherapeutic and therapeutic concen
Autor:
Donna S. Cox, Mohammad Hossain, Jogarao V. S. Gobburu, Duane A. Boyle, Bela Rajiv Patel, Young-Moon Choi, Guy Young, Rajanikanth Madabushi
Publikováno v:
Journal of clinical pharmacology. 51(1)
The objective was to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of argatroban in pediatric patients and derive dosing recommendations. An open-label multicenter trial was conducted in pediatric patients (n = 18 from birth to 16