Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bela Malik"'
Publikováno v:
American Journal of Physiology-Cell Physiology. 289:C717-C726
Several studies have shown that nitric oxide (NO) inhibits Na+transport in renal and alveolar monolayers. However, the mechanisms by which NO alters epithelial Na+channel (ENaC) activity is unclear. Therefore, we examined the effect of applying the N
Autor:
Carmel M. McNicholas-Bevensee, James D. Fortenberry, Sadis Matalon, Douglas C. Eaton, Carpantato Myles, Bela Malik, Karin M. Hardiman
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 30:720-728
We investigated the mechanisms of endogenous nitric oxide (NO) modulation of lung sodium (Na(+)) transport. C57BL/6 mice injected intraperitoneally with the specific inducible NO synthase (iNOS) inhibitor 1400W (10 mg/kg every 8 h for 72 h) exhibited
Publikováno v:
Journal of Biological Chemistry. 277:11965-11969
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a membrane lipid found in all eukaryotic cells, which regulates many important cellular processes, including ion channel activity. In this study, we used inside-out patch clamp technique, immunoprecip
Publikováno v:
Journal of Membrane Biology. 184:313-319
Aldosterone maintains total organism sodium balance in all higher vertebrates. The level of sodium reabsorption is primarily determined by the action of aldosterone on epithelial sodium channels (ENaC) in the distal nephron. Recent work shows that, i
Autor:
Otor Al-Khalili, Hui-Fang Bao, Guichun Yue, Lynn E. Schlanger, William E. Mitch, Bela Malik, S. Price, Douglas C. Eaton
Publikováno v:
Journal of Biological Chemistry. 276:12903-12910
Amiloride-sensitive epithelial Na(+) channels (ENaC) are responsible for trans-epithelial Na(+) transport in the kidney, lung, and colon. The channel consists of three subunits (alpha, beta, gamma) each containing a proline rich region (PPXY) in thei
Autor:
Bela Malik, William J. Ball, Purabi Dey, Michael N. Margolies, Zhen-Ming Wang, Rama Kasturi, Mary K. Short
Publikováno v:
Journal of Molecular Biology. 301:101-115
Since the initial report of the development of methodology to generate high-affinity digitalis-specific (digoxin) antibodies, these antibodies have proven extremely useful tools to monitor digoxin levels in digitalized patients and, as Fab fragments,
Autor:
Pam Middleton, Bela Malik, Douglas C. Eaton, Lynn E. Schlanger, Julie Schenck, James D. Stockand, Hui-Fang Bao
Publikováno v:
Journal of Biological Chemistry. 275:25760-25765
Regulation of epithelial Na(+) channel (ENaC) subunit levels by protein kinase C (PKC) was investigated in A6 cells. PKC activation altered ENaC subunit levels, differentially decreasing the levels of both beta and gamma, but not alphaENaC. Temporal
Autor:
Christopher F. Martin, Douglas C. Eaton, Jeff M. Sands, Raed N. Bou Matar, Janet D. Klein, Xiaonan H. Wang, Bela Malik
Salt and water retention is a hallmark of nephrotic syndrome (NS). In this study, we test for changes in the abundance of urea transporters, aquaporin 2 (AQP2), Na-K-2Cl cotransporter 2 (NKCC2), and Na-Cl cotransporter (NCC), in non-pair-fed and pair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54af66e135f8b3bd72cdc1f941539ab
https://europepmc.org/articles/PMC3378098/
https://europepmc.org/articles/PMC3378098/
Publikováno v:
The FASEB Journal. 25
Publikováno v:
Protein Science. 2:2103-2111
Monoclonal antibodies that bind native protein can generate considerable information about structure/function relationships, but identification of their epitopes can be problematic. Previously, monoclonal antibody M8-P1-A3 has been shown to bind to t