Time-of-flight secondary ion mass spectrometry to assess spatial distribution of A2E and its oxidized forms within lipofuscin granules isolated from human retinal pigment epithelium.

Autor: Yakovleva MA; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, Moscow, 119334, Russia., Gulin AA; Semenov Institute of Chemical Physics, Russian Academy of Sciences, Kosygin st. 4, Moscow, 119991, Russia.; Department of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow, 119991, Russia., Feldman TB; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, Moscow, 119334, Russia. feldmantb@mail.ru.; Department of Molecular Physiology, Biological Faculty, Lomonosov Moscow State University, Leninskie Gory1, Moscow, 119991, Russia. feldmantb@mail.ru., Bel'skich YC; Department of Molecular Physiology, Biological Faculty, Lomonosov Moscow State University, Leninskie Gory1, Moscow, 119991, Russia., Arbukhanova PM; Sv. Fyodorov Eye Microsurgery Complex, Beskudnikovsky bld. 59a, Moscow, 127486, Russia., Astaf'ev AA; Semenov Institute of Chemical Physics, Russian Academy of Sciences, Kosygin st. 4, Moscow, 119991, Russia., Nadtochenko VA; Semenov Institute of Chemical Physics, Russian Academy of Sciences, Kosygin st. 4, Moscow, 119991, Russia.; Department of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow, 119991, Russia., Borzenok SA; Sv. Fyodorov Eye Microsurgery Complex, Beskudnikovsky bld. 59a, Moscow, 127486, Russia., Ostrovsky MA; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, Moscow, 119334, Russia.; Department of Molecular Physiology, Biological Faculty, Lomonosov Moscow State University, Leninskie Gory1, Moscow, 119991, Russia.

Publikováno v: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2016 Oct; Vol. 408 (26), pp. 7521-8. Date of Electronic Publication: 2016 Aug 10.