Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Bekim Bajrami"'
Autor:
Antonio Valencia, Veronica L. Reinhart Bieber, Bekim Bajrami, Galina Marsh, Stefan Hamann, Ru Wei, Karen Ling, Frank Rigo, H. Moore Arnold, Olga Golonzhka, Heike Hering
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Acetylation of tau protein is dysregulated in Alzheimer's Disease (AD). It has been proposed that acetylation of specific sites in the KXGS motif of tau can regulate phosphorylation of nearby residues and reduce the propensity of tau to aggregate. Hi
Externí odkaz:
https://doaj.org/article/a41a157c36224752816979d8bd348864
Autor:
Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Bin Ma, Isaac Marx, Robin Prince, Allie M Roach, Urjana Poreci, Douglas Donaldson, Patrick Cullen, Fergal Casey, Jing Zhu, Thomas M Carlile, Dipen Sangurdekar, Baohong Zhang, Patrick Trapa, Joseph Santoro, Param Muragan, Alex Pellerin, Stephen Rubino, Davide Gianni, Bekim Bajrami, Xiaomei Peng, Alex Coppell, Katherine Riester, Shibeshih Belachew, Devangi Mehta, Mike Palte, Brian T Hopkins, Matthew Scaramozza, Nathalie Franchimont, Michael Mingueneau
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB09
Externí odkaz:
https://doaj.org/article/960649d0c0f948e3add268a6d5cc0401
Autor:
Jeremy Carlos Burns, Bunny Cotleur, Dirk M Walther, Bekim Bajrami, Stephen J Rubino, Ru Wei, Nathalie Franchimont, Susan L Cotman, Richard M Ransohoff, Michael Mingueneau
Publikováno v:
eLife, Vol 9 (2020)
To date, microglia subsets in the healthy CNS have not been identified. Utilizing autofluorescence (AF) as a discriminating parameter, we identified two novel microglia subsets in both mice and non-human primates, termed autofluorescence-positive (AF
Externí odkaz:
https://doaj.org/article/2da604ca9b974a5299cfeca64a35662e
Autor:
Gregory M Dillon, Jaclyn L Henderson, Channa Bao, John A Joyce, Michael Calhoun, Brenda Amaral, Kristopher W King, Bekim Bajrami, Dania Rabah
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228771 (2020)
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating eve
Externí odkaz:
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
Autor:
Frank C Nichols, Xudong Yao, Bekim Bajrami, Julia Downes, Sydney M Finegold, Erica Knee, James J Gallagher, William J Housley, Robert B Clark
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16771 (2011)
Novel phosphorylated dihydroceramide (PDHC) lipids produced by the periodontal pathogen Porphyromonas gingivalis include phosphoethanolamine (PE DHC) and phosphoglycerol dihydroceramides (PG DHC) lipids. These PDHC lipids mediate cellular effects thr
Externí odkaz:
https://doaj.org/article/dcbdf256453747b9b53f9b62d8369edc
Autor:
Brenda Amaral, Andrew Capacci, Trip Anderson, Ceren Tezer, Bekim Bajrami, Mukesh Lulla, Brian Lucas, Jayanth V. Chodaparambil, Douglas Marcotte, P. Rajesh Kumar, Paramasivam Murugan, Kerri Spilker, Mike Cullivan, Ti Wang, Anton C. Peterson, Istvan Enyedy, Bin Ma, TeYu Chen, Zain Yousaf, Michael Calhoun, Olga Golonzhka, Gregory M. Dillon, Samir Koirala
Publikováno v:
ACS Chemical Neuroscience. 14:1080-1094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e2475b48301c4e503991c19a53b9f3a
https://doi.org/10.1021/acschemneuro.2c00476
https://doi.org/10.1021/acschemneuro.2c00476
Identifying probe-modified peptides in chemical proteomics experiments is challenging due to the production of only one modified peptide per probe reaction at a specific site on a protein and the possibility of inconclusive proteomic identification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77aa64678b34bda673798d54ac82551a
https://doi.org/10.26434/chemrxiv-2023-8w3vf
https://doi.org/10.26434/chemrxiv-2023-8w3vf
Publikováno v:
Mass Spectrometry Reviews.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43dd442f075bec9bdf6a175a9d3293d8
https://doi.org/10.1002/mas.21837
https://doi.org/10.1002/mas.21837
Autor:
Kevin L. Otipoby, Sarah Sheikh, Douglas Marcotte, George A. Moniz, Michael Humora, Brian T. Hopkins, Judy Bai, Karen Smirnakis, J. Michael Macphee, Tonika Bohnert, Timothy R. Chan, Devangi Mehta, Bin Ma, Million Arefayene, Zheng Fengmei, Lei Zhang, Patricia Schroeder, Annick Prefontaine, Eris Bame, Urjana Poreci, Evelyne Polack, Eric Tien, Claire M. Metrick, Bekim Bajrami
Publikováno v:
Journal of Medicinal Chemistry. 63:12526-12541
Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic role in autoimmune diseases. In systemic lupus erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory cytokine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7847a2561125cd5a06e20ac411c45701
https://doi.org/10.1021/acs.jmedchem.0c00702
https://doi.org/10.1021/acs.jmedchem.0c00702
Autor:
Jayanth V. Chodaparambil, Benbo Gao, Gregory M Dillon, Hannah M. Kerns, Jaclyn L. Henderson, Douglas Marcotte, Ru Wei, Bekim Bajrami, Channa Bao
Publikováno v:
Cellular and Molecular Neurobiology. 41:669-685
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785ba6754ca160aed7d4ffda2a0c284a
https://doi.org/10.1007/s10571-020-00875-6
https://doi.org/10.1007/s10571-020-00875-6