Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

Autor: Bekes, Erin M., Deryugina, Elena I., Kupriyanova, Tatyana A., Zajac, Ewa, Botkjaer, Kenneth A., Andreasen, Peter A., Quigley, James P.

Publikováno v: In Neoplasia September 2011 13(9):806

Targeting Tumor Cell Invasion and Dissemination In Vivo by an Aptamer That Inhibits Urokinase-type Plasminogen Activator through a Novel Multifunctional Mechanism

Autor: Botkjaer, Kenneth A, Deryugina, Elena I, Dupont, Daniel M, Gårdsvoll, Henrik, Bekes, Erin M, Thuesen, Cathrine K, Chen, Zhou, Ploug, Michael, Quigley, James P, Andreasen, Peter

Publikováno v: Botkjaer, K A, Deryugina, E I, Dupont, D M, Gårdsvoll, H, Bekes, E M, Thuesen, C K, Chen, Z, Ploug, M, Quigley, J P & Andreasen, P 2012, ' Targeting Tumor Cell Invasion and Dissemination In Vivo by an Aptamer That Inhibits Urokinase-type Plasminogen Activator through a Novel Multifunctional Mechanism ', Molecular Cancer Research, vol. 10, no. 12, pp. 1532-1543 . https://doi.org/10.1158/1541-7786.MCR-12-0349

Data accumulated over the latest two decades have established that the serine protease urokinase-type plasminogen activator (uPA) is a potential therapeutic target in cancer. When designing inhibitors of the proteolytic activity of serine proteases,

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