Looking Under the Hood at the Cytoskeletal Engine of Platelet Production.

Autor: Italiano JE Jr; Vascular Biology Program, Boston Children's Hospital, MA (J.E.I., C.P., R.H.B.).; Department of Surgery, Harvard Medical School, Boston, MA (J.E.I., C.P., R.H.B.)., Payne C; Vascular Biology Program, Boston Children's Hospital, MA (J.E.I., C.P., R.H.B.).; Department of Surgery, Harvard Medical School, Boston, MA (J.E.I., C.P., R.H.B.)., Bekendam RH; Vascular Biology Program, Boston Children's Hospital, MA (J.E.I., C.P., R.H.B.).; Department of Surgery, Harvard Medical School, Boston, MA (J.E.I., C.P., R.H.B.).; Division of Hematology and Hematologic Malignancies, Beth Israel Deaconess Medical Center, Boston, MA (R.H.B.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.

Targeting thiol isomerase activity with zafirlukast to treat ovarian cancer from the bench to clinic.

Autor: Gelzinis JA; College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, USA.; Institute for Cardiovascular & Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Szahaj MK; College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, USA., Bekendam RH; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Wurl SE; College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, USA., Pantos MM; College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, USA., Verbetsky CA; College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, USA., Dufresne A; Baystate Research Facility, Baystate Medical Center, UMass Chan Medical School, Springfield, Massachusetts, USA., Shea M; Division of Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Howard KC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, Kentucky, 40536, USA., Tsodikov OV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, Kentucky, 40536, USA., Garneau-Tsodikova S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, Kentucky, 40536, USA., Zwicker JI; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Kennedy DR; College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, USA.; Institute for Cardiovascular & Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK.; Department of Medicine, UMass Chan Medical School-Baystate, Springfield, Massachusetts, USA.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 May; Vol. 37 (5), pp. e22914.

Emerging Factors Implicated in Fibrotic Organ-Associated Thrombosis: The Case of Two Organs.

Autor: Leiva O; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States., Bekendam RH; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States., Garcia BD; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.; Department of Medicine, Mount Auburn Hospital and Harvard Medical School, Boston, Massachusetts, United States., Thompson C; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States., Cantor A; Children's Hospital Boston, Boston, Massachusetts, United States., Chitalia V; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States.; VA Boston Healthcare System, Boston, Massachusetts, United States., Ravid K; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States.

Publikováno v: TH open : companion journal to thrombosis and haemostasis [TH Open] 2019 Jun 07; Vol. 3 (2), pp. e165-e170. Date of Electronic Publication: 2019 Jun 07 (Print Publication: 2019).

Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation.

Autor: Bekendam RH; Aix Marseille Université, INSERM, UMR-S1076, Vascular Research Center Marseille, Marseille, France.; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Iyu D; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Departamento de Fisiología. Facultad de Medicina, Instituto Murciano de Investigación Biosanitaria (IMIB), Universidad de Murcia, Murcia, Spain., Passam F; St George Clinical School, University of New South Wales, Kogarah, New South Wales, Australia., Stopa JD; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., De Ceunynck K; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Muse O; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Bendapudi PK; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Garnier CL; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Gopal S; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Crescence L; Aix Marseille Université, INSERM, UMR-S1076, Vascular Research Center Marseille, Marseille, France., Chiu J; The Centenary Institute, NHMRC Clinical Trials Centre, Sydney Medical School, University of Sydney New South Wales, Sydney, New South Wales, Australia., Furie B; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Panicot-Dubois L; Aix Marseille Université, INSERM, UMR-S1076, Vascular Research Center Marseille, Marseille, France., Hogg PJ; The Centenary Institute, NHMRC Clinical Trials Centre, Sydney Medical School, University of Sydney New South Wales, Sydney, New South Wales, Australia., Dubois C; Aix Marseille Université, INSERM, UMR-S1076, Vascular Research Center Marseille, Marseille, France., Flaumenhaft R; Department of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2018 Nov; Vol. 16 (11), pp. 2322-2335. Date of Electronic Publication: 2018 Oct 12.

A substrate-driven allosteric switch that enhances PDI catalytic activity.

Autor: Bekendam RH; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA., Bendapudi PK; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA., Lin L; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA., Nag PP; Department of Pharmaceutical and Administrative Sciences, The Broad Institute Probe Development Center, Cambridge, Massachusetts 02142, USA.; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts 02142, USA., Pu J; Department of Pharmaceutical and Administrative Sciences, The Broad Institute Probe Development Center, Cambridge, Massachusetts 02142, USA., Kennedy DR; College of Pharmacy, Western New England University, Springfield, Massachusetts 01119, USA., Feldenzer A; College of Pharmacy, Western New England University, Springfield, Massachusetts 01119, USA., Chiu J; The Centenary Institute, Newtown, Sydney, New South Wales 2050, Australia.; National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, New South Wales 2050, Australia., Cook KM; The Centenary Institute, Newtown, Sydney, New South Wales 2050, Australia., Furie B; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA., Huang M; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA., Hogg PJ; The Centenary Institute, Newtown, Sydney, New South Wales 2050, Australia.; National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, New South Wales 2050, Australia., Flaumenhaft R; Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

Publikováno v: Nature communications [Nat Commun] 2016 Aug 30; Vol. 7, pp. 12579. Date of Electronic Publication: 2016 Aug 30.