Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Beixi Wang"'
Autor:
Farhia Kabeer, Hoa Tran, Mirela Andronescu, Gurdeep Singh, Hakwoo Lee, Sohrab Salehi, Beixi Wang, Justina Biele, Jazmine Brimhall, David Gee, Viviana Cerda, Ciara O’Flanagan, Teresa Algara, Takako Kono, Sean Beatty, Elena Zaikova, Daniel Lai, Eric Lee, Richard Moore, Andrew J. Mungall, IMAXT Consortium, Marc J. Williams, Andrew Roth, Kieran R. Campbell, Sohrab P. Shah, Samuel Aparicio
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)
Abstract Background The encoding of cell intrinsic drug resistance states in breast cancer reflects the contributions of genomic and non-genomic variations and requires accurate estimation of clonal fitness from co-measurement of transcriptomic and g
Externí odkaz:
https://doaj.org/article/49d08f6904d04bb2b5f01bd4a5faa66b
Autor:
Peter Eirew, Ciara O’Flanagan, Jerome Ting, Sohrab Salehi, Jazmine Brimhall, Beixi Wang, Justina Biele, Teresa Algara, So Ra Lee, Corey Hoang, Damian Yap, Steven McKinney, Cherie Bates, Esther Kong, Daniel Lai, Sean Beatty, Mirela Andronescu, Elena Zaikova, Tyler Funnell, Nicholas Ceglia, Stephen Chia, Karen Gelmon, Colin Mar, Sohrab Shah, Andrew Roth, Alexandre Bouchard-Côté, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Gene fitness and essentiality analyses using in vivo cancer models are challenging due to multiple confounders. Here, the authors develop a quantitative approach to study CRISPR-transduced patient-derived xenografts, which they use to analyse in vivo
Externí odkaz:
https://doaj.org/article/5fd8470d7bc644e19c6718168d7a7669
Autor:
Kieran R. Campbell, Adi Steif, Emma Laks, Hans Zahn, Daniel Lai, Andrew McPherson, Hossein Farahani, Farhia Kabeer, Ciara O’Flanagan, Justina Biele, Jazmine Brimhall, Beixi Wang, Pascale Walters, IMAXT Consortium, Alexandre Bouchard-Côté, Samuel Aparicio, Sohrab P. Shah
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Measuring gene expression of tumor clones at single-cell resolution links functional consequences to somatic alterations. Without scalable methods to simultaneously assay DNA and RNA from the same single cell, parallel single-cell DNA and RN
Externí odkaz:
https://doaj.org/article/7acfee3bde96437aa516497973101d2b
Autor:
Camila P E de Souza, Mirela Andronescu, Tehmina Masud, Farhia Kabeer, Justina Biele, Emma Laks, Daniel Lai, Patricia Ye, Jazmine Brimhall, Beixi Wang, Edmund Su, Tony Hui, Qi Cao, Marcus Wong, Michelle Moksa, Richard A Moore, Martin Hirst, Samuel Aparicio, Sohrab P Shah
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008270 (2020)
We present Epiclomal, a probabilistic clustering method arising from a hierarchical mixture model to simultaneously cluster sparse single-cell DNA methylation data and impute missing values. Using synthetic and published single-cell CpG datasets, we
Externí odkaz:
https://doaj.org/article/95e95387e9fb465bb06950a35a44a9d9
Autor:
Subrata Chowdhury, Larson Grimm, Ying Jia Kate Gong, Beixi Wang, Bing Li, Coimbatore B Srikant, Zu-hua Gao, Jun-Li Liu
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136656 (2015)
We have reported a high expression of IGF-I in pancreatic islet β-cells of transgenic mice under the metallothionein promoter. cDNA microarray analysis of the islets revealed that the expression of 82 genes was significantly altered compared to wild
Externí odkaz:
https://doaj.org/article/089ebf6f02bd4dbda89f1c30375bb4cf
Publikováno v:
Translational Cancer Research
Background RGMB antisense RNA 1 (RGMB-AS1) is a member of long non-coding RNAs (lncRNAs) and relates to the carcinogenesis of numerous cancers. Nonetheless, its performance and mechanism in cervical cancer (CC) is unclear. Methods The expressions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9937581dfaf95f11fbf1fb5e0accb7
https://doi.org/10.21037/tcr.2020.04.19
https://doi.org/10.21037/tcr.2020.04.19
Autor:
Beatty S, Britta Weigelt, Havasov E, Douglas Jm, Beixi Wang, Samuel Aparicio, Steven McKinney, Samantha Leung, Hakwoo Lee, Brimhall J, Marc J Williams, Yang Li, Sohrab P. Shah, Justina Biele, Jamie L. P. Lim, Funnell T, Da Cruz Paula A, Ciara H. O'Flanagan, Andrew McPherson, Damian Yap, Nicholas Ceglia, Diljot Grewal, Weiner Ac, Sarah H. Kim, Allen Zhang, Ruiz de Algara T, Lee, Cerda Llanos, Liu Yf, Peter Eirew, Jorge S. Reis-Filho, Dmitriy Zamarin, Abrams D, Tehmina Masud, Daniel Lai, Bojilova, Richard A. Moore, Xu H, Farhia Kabeer, Nicole Rusk, Florian Uhlitz, Jerome Ting, Jenifer Pham
Structural genome alterations are determinants of cancer ontogeny and therapeutic response. While bulk genome sequencing has enabled delineation of structural variation (SV) mutational processes which generate patterns of DNA damage, we have little u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbca175098a6792741c75961dca47af5
https://doi.org/10.1101/2021.06.03.446999
https://doi.org/10.1101/2021.06.03.446999
Autor:
Tyler, Funnell, Ciara H, O'Flanagan, Marc J, Williams, Andrew, McPherson, Steven, McKinney, Farhia, Kabeer, Hakwoo, Lee, Sohrab, Salehi, Ignacio, Vázquez-García, Hongyu, Shi, Emily, Leventhal, Tehmina, Masud, Peter, Eirew, Damian, Yap, Allen W, Zhang, Jamie L P, Lim, Beixi, Wang, Jazmine, Brimhall, Justina, Biele, Jerome, Ting, Vinci, Au, Michael, Van Vliet, Yi Fei, Liu, Sean, Beatty, Daniel, Lai, Jenifer, Pham, Diljot, Grewal, Douglas, Abrams, Eliyahu, Havasov, Samantha, Leung, Viktoria, Bojilova, Richard A, Moore, Nicole, Rusk, Florian, Uhlitz, Nicholas, Ceglia, Adam C, Weiner, Elena, Zaikova, J Maxwell, Douglas, Dmitriy, Zamarin, Britta, Weigelt, Sarah H, Kim, Arnaud, Da Cruz Paula, Jorge S, Reis-Filho, Spencer D, Martin, Yangguang, Li, Hong, Xu, Teresa Ruiz, de Algara, So Ra, Lee, Viviana Cerda, Llanos, David G, Huntsman, Jessica N, McAlpine, Sohrab P, Shah, Pu, Zheng
Publikováno v:
Nature. 612(7938)
How cell-to-cell copy number alterations that underpin genomic instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::baaf3b0746b71635075b84546a6965ab
https://pubmed.ncbi.nlm.nih.gov/36289342
https://pubmed.ncbi.nlm.nih.gov/36289342
Autor:
Samuel Aparicio, Kieran R Campbell, Beixi Wang, Emma Laks, Hossein Farahani, Andrew McPherson, Hans Zahn, David Lai, Sohrab P. Shah, Ciara H. O'Flanagan, Pascale Walters, Justina Biele, Alexandre Bouchard-Côté, Farhia Kabeer, Adi Steif, Jazmine Brimhall
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Genome Biology
Genome Biology
Measuring gene expression of tumor clones at single-cell resolution links functional consequences to somatic alterations. Without scalable methods to simultaneously assay DNA and RNA from the same single cell, parallel single-cell DNA and RNA measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5310cf61c009b92a4dfc8d68a4409dc7
http://link.springer.com/article/10.1186/s13059-019-1645-z
http://link.springer.com/article/10.1186/s13059-019-1645-z
Autor:
Peter Eirew, Ciara O’Flanagan, Jerome Ting, Sohrab Salehi, Jazmine Brimhall, Beixi Wang, Justina Biele, Teresa Algara, So Ra Lee, Corey Hoang, Damian Yap, Steven McKinney, Cherie Bates, Esther Kong, Daniel Lai, Sean Beatty, Mirela Andronescu, Elena Zaikova, Tyler Funnell, Nicholas Ceglia, Stephen Chia, Karen Gelmon, Colin Mar, Sohrab Shah, Andrew Roth, Alexandre Bouchard-Côté, Samuel Aparicio
Publikováno v:
Nature communications. 13(1)
Assessing tumour gene fitness in physiologically-relevant model systems is challenging due to biological features of in vivo tumour regeneration, including extreme variations in single cell lineage progeny. Here we develop a reproducible, quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d82413c3a5f0d91a6500088bcc254e
https://pubmed.ncbi.nlm.nih.gov/35927228
https://pubmed.ncbi.nlm.nih.gov/35927228