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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.

Autor: Velcicky J; Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland., Mathison CJN; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Nikulin V; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Pflieger D; Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland., Epple R; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Azimioara M; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Cow C; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Michellys PY; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Rigollier P; Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland., Beisner DR; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Bodendorf U; Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland., Guerini D; Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland., Liu B; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Wen B; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Zaharevitz S; The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Brandl T; Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 May 23; Vol. 10 (6), pp. 887-892. Date of Electronic Publication: 2019 May 23 (Print Publication: 2019).

Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.

Autor: Miller AT; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Dahlberg C; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Sandberg ML; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Wen BG; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Beisner DR; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Hoerter JA; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Parker A; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Schmedt C; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Stinson M; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Avis J; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Cienfuegos C; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., McPate M; Novartis Pharmaceuticals UK Limited, Respiratory Disease Area, Horsham, West Sussex, United Kingdom., Tranter P; Novartis Pharmaceuticals UK Limited, Respiratory Disease Area, Horsham, West Sussex, United Kingdom., Gosling M; Novartis Pharmaceuticals UK Limited, Respiratory Disease Area, Horsham, West Sussex, United Kingdom., Groot-Kormelink PJ; Novartis Institutes for Biomedical Research, Musculoskeletal Disease Area, Basel, Switzerland., Dawson J; Novartis Pharma AG, Novartis Institutes for Biomed. Research, Basel, Switzerland., Pan S; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Tian SS; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Seidel HM; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America., Cooke MP; The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America.

Publikováno v: PloS one [PLoS One] 2015 Jun 29; Vol. 10 (6), pp. e0131071. Date of Electronic Publication: 2015 Jun 29 (Print Publication: 2015).

Foxo transcription factors control regulatory T cell development and function.

Autor: Kerdiles YM; Molecular Biology Section, Division of Biological Sciences and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0377, USA., Stone EL, Beisner DR, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM

Publikováno v: Immunity [Immunity] 2010 Dec 14; Vol. 33 (6), pp. 890-904.

Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction.

Autor: Miller AT; The Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA., Beisner DR, Liu D, Cooke MP

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2009 Apr 15; Vol. 182 (8), pp. 4696-704.