Zobrazeno 1 - 10
of 734
pro vyhledávání: '"Beisha, Tang"'
Autor:
Shiyu Zhang, Zheng Wang, Yijing Wang, Yixiao Zhu, Qiao Zhou, Xingxing Jian, Guihu Zhao, Jian Qiu, Kun Xia, Beisha Tang, Julian Mutz, Jinchen Li, Bin Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 representative aging-related biomarkers associated with all-cause mortality. W
Externí odkaz:
https://doaj.org/article/c603a664612e43f99fdb8d1fec1514d6
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2024)
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease. The development of PD is closely linked to genetic and environmental factors, with GBA1 variants being the most common genetic risk. Mutations in the GBA1 gene l
Externí odkaz:
https://doaj.org/article/e213dfb10fb64274a351acc6af2febaa
Autor:
Sudan Zhu, Yuting Shi, Zhao Chen, Zhe Long, Linlin Wan, Daji Chen, Xinrong Yuan, You Fu, Feiyan Deng, Xiafei Long, Kefang Du, Rong Qiu, Beisha Tang, Chunrong Wang, Hong Jiang
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 8, Pp 2100-2111 (2024)
Abstract Objective Transcranial sonography (TCS) is a noninvasive neuroimaging technique, visualizing deep brain structures and the ventricular system. Although widely employed in diagnosing various movement disorders, such as Parkinson's disease and
Externí odkaz:
https://doaj.org/article/3a8c5057010f435d81054bfcd997773b
Autor:
Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay R. Holstein, Beisha Tang, Junmin Peng, Nan Yang, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human n
Externí odkaz:
https://doaj.org/article/71903ec458994596b1e2fc44fc246235
Autor:
Yuwen Zhao, Lixia Qin, Hongxu Pan, Tingwei Song, Yige Wang, Xiaoxia Zhou, Yaqin Xiang, Jinchen Li, Zhenhua Liu, Qiying Sun, Jifeng Guo, Xinxiang Yan, Beisha Tang, Qian Xu, Ting Gao, Xiuyuan Hao
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 4, Pp 450-456 (2024)
Abstract. Background:. Genetic variants of dopaminergic transcription factor-encoding genes are suggested to be Parkinson's disease (PD) risk factors; however, no comprehensive analyses of these genes in patients with PD have been undertaken. Therefo
Externí odkaz:
https://doaj.org/article/3589daf9463b4e0c83eb7ea7505feabf
Autor:
Bin Jiao, Ziyu Ouyang, Qianqian Liu, Tianyan Xu, Meidan Wan, Guangrong Ma, Lu Zhou, Jifeng Guo, Junling Wang, Beisha Tang, Zhixiang Zhao, Lu Shen
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTThe role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrared spectroscopy (fNIRS) in a cohort of 164 par
Externí odkaz:
https://doaj.org/article/b430b8bd7d9f4fcf8146a500fac24085
Autor:
Yuanfeng Huang, Qian Chen, Zheng Wang, Yijing Wang, Aojie Lian, Qiao Zhou, Guihu Zhao, Kun Xia, Beisha Tang, Bin Li, Jinchen Li
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Substantial evidence shown that the age at onset (AAO) of Parkinson’s disease (PD) is a major determinant of clinical heterogeneity. However, the mechanisms underlying heterogeneity in the AAO remain unclear. To investigate the risk factor
Externí odkaz:
https://doaj.org/article/2ab4e991460f4a9ea0541ae83a60696e
Autor:
Linxin Tang, Xuxiong Tang, Qianqian Zhao, Yongchao Li, Yue Bu, Zhen Liu, Jinchen Li, Jifeng Guo, Lu Shen, Hong Jiang, Beisha Tang, Renshi Xu, Wenfeng Cao, Yanchun Yuan, Junling Wang
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 1, Pp 79-88 (2024)
Abstract Introduction Recently, chloride channel CLIC‐like 1 (CLCC1) was reported to be a novel ALS‐related gene. We aimed to screen CLCC1 variants in our ALS cohort and further explore the genotype–phenotype correlation of CLCC1‐related ALS.
Externí odkaz:
https://doaj.org/article/d0449d7c118948dbbab6f62a8bce4c55
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-30 (2023)
Abstract Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases. The typical symptomatology of PD includes motor symptoms; however, a range of nonmotor symptoms, such as intestinal issues, usually occur before the motor sy
Externí odkaz:
https://doaj.org/article/213a2dc6b7404161bf9c672043bef246
Autor:
Riwei Ouyang, Linlin Wan, David Pellerin, Zhe Long, Jian Hu, Qian Jiang, Chunrong Wang, Linliu Peng, Huirong Peng, Lang He, Rong Qiu, Junling Wang, Jifeng Guo, Lu Shen, Bernard Brais, Matt C. Danzi, Stephan Zuchner, Beisha Tang, Zhao Chen, Hong Jiang
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105077- (2024)
Summary: Background: An intronic GAA repeat expansion in FGF14 was recently identified as a cause of GAA-FGF14 ataxia. We aimed to characterise the frequency and phenotypic profile of GAA-FGF14 ataxia in a large Chinese ataxia cohort. Methods: A tota
Externí odkaz:
https://doaj.org/article/86b04fea61334ffe80f3605964adc1ba