Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Beirong Gao"'
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 73K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9ea91e81a67f3f040a1bb9626f1a13
https://doi.org/10.1158/1535-7163.22498635
https://doi.org/10.1158/1535-7163.22498635
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 84K, Correlation of AZD5363 activity in cell lines from different tumor types with RAS, PIK3CA and PTEN status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26adbc826f9cc85329a52ca84cf29cd2
https://doi.org/10.1158/1535-7163.22498644.v1
https://doi.org/10.1158/1535-7163.22498644.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 81K, Correlation of AZD5363 activity in cell lines from different tumor types with PIK3CA and PTEN mutation status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aca16ca8976daf5767839bc44394ac
https://doi.org/10.1158/1535-7163.22498647
https://doi.org/10.1158/1535-7163.22498647
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 88K, Quantification of cleaved caspase 3 activity in HCC-1187 xenografts following chronic dosing with 5 mg/kg once weekly docetaxel (taxotere), 150 mg/kg bid AZD5363, or a combination of these two agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3112b5ae732cb14b1fb9210be4bf92
https://doi.org/10.1158/1535-7163.22498638.v1
https://doi.org/10.1158/1535-7163.22498638.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 139K, AZD5363 has a predominantly anti-proliferative mechanism of action but induces cell death in BT474c, LNCaP and PC346C-Flut1 cells in vitro, and in BT474c xenografts following a high, intermittent dosing schedule in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eda9af138e0854ae982cf0930bd6d1
https://doi.org/10.1158/1535-7163.22498641
https://doi.org/10.1158/1535-7163.22498641
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 117K, AZD5363 inhibits S6 phosphorylation in TSC1 -/-, TSC2 low-expressing RT4 bladder cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0694b929ca9bbf6674a0e14b9be57b20
https://doi.org/10.1158/1535-7163.22498650.v1
https://doi.org/10.1158/1535-7163.22498650.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
AKT is a key node in the most frequently deregulated signaling network in human cancer. AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cc27e4c5c098c582d92d81ddb5859a
https://doi.org/10.1158/1535-7163.c.6535935
https://doi.org/10.1158/1535-7163.c.6535935
Autor:
Hannah Greenwood, Jingchuan Zhang, Jing Li, Rebecca Watson, Juliana Maynard, James W.T. Yates, Claire Crafter, Beirong Gao, Sally-Ann Ricketts, Darren Cross, Martin Pass, Clare Lane, Christine M. Chresta, Barry R. Davies, Sabina Cosulich, Ken M Page, Philippa Dudley, Qunsheng Ji, Richard W. A. Luke, De-Hua Yu, Donald J. Ogilvie
Publikováno v:
Molecular Cancer Therapeutics. 11:873-887
AKT is a key node in the most frequently deregulated signaling network in human cancer. AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrate
Autor:
Ziliang, Qian, Guanshan, Zhu, Lili, Tang, Mei, Wang, Lianhai, Zhang, Jiangang, Fu, Chunlei, Huang, Shuqiong, Fan, Yun, Sun, Jing, Lv, Hua, Dong, Beirong, Gao, Xinying, Su, Dehua, Yu, Jie, Zang, Xiaolin, Zhang, Jiafu, Ji, Qunsheng, Ji
Publikováno v:
Genes, chromosomescancer. 53(11)
Gastric cancer is the second leading cause of death from cancer worldwide, with an approximately 20% 5-year survival rate. To identify molecular subtypes associated with the clinical prognosis, in addition to genetic aberrations for potential targete
Autor:
Danping Shen, Xiaolin Zhang, Paul R. Gavine, Kunji Liu, Xiuhua Zhang, Minhua Zhou, Yanping Xu, Lin Zhang, Jingchuan Zhang, Elaine Kilgour, Liang Xie, Xinying Su, Jiafu Ji, Xiaolu Yin, Zeren Gao, Lili Tang, Lianhai Zhang, Beirong Gao, Qunsheng Ji
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 19(9)
Purpose: FGFR gene aberrations are associated with tumor growth and survival. We explored the role of FGFR2 amplification in gastric cancer and the therapeutic potential of AZD4547, a potent and selective ATP-competitive receptor tyrosine kinase inhi